fMRI of Emotion Regulation During RCT of CBT vs. MBSR for Social Anxiety Disorder

CBT 与 MBSR 治疗社交焦虑症的随机对照试验期间情绪调节的功能磁共振成像 (fMRI)

基本信息

批准号：
8449242
负责人：
JAMES J GROSS
金额：
$ 58.33万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-03-01 至 2016-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8449242
关键词：
Address Adult Aftercare Anxiety Anxiety Disorders Attention Behavioral Brain region Clinical Clinical Sciences Cognitive Cognitive Therapy Diagnostic Dorsal Emotional Emotions Evaluation Fright Functional Magnetic Resonance Imaging Goals Health Individual Individual Differences Intervention Interview Knowledge Literature Mediating Mental disorders Modality Mood Disorders Neurosciences Research Outcome Patients Personal Satisfaction Play Process Questionnaires Randomized Regulation Relative (related person)Reporting Research Role Severities Social Controls Social Environment Stimulus Symptoms Testing Therapeutic Therapeutic Effect Translational Research Work arm base design effective therapy emotion regulation follow-up improved mindfulness-based stress reduction neuroimaging programs psychosocial public health relevance relating to nervous system response social therapy outcome

项目摘要

DESCRIPTION (provided by applicant): Emotion dysregulation is thought to be a core mechanism underlying many Axis-I and Axis-II psychiatric disorders. In particular, emotion dysregulation is believed to play a crucial role in the anxiety and mood disorders. A growing body of empirical work is beginning to illuminate the neural correlates and behavioral sequelae of emotion dysregulation in individuals suffering from anxiety and mood disorders. However, little is known about how psychosocial treatments for anxiety and mood disorders impact emotion dysregulation. The proposed study will directly address this gap in our knowledge by examining how two psychosocial treatment modalities-Cognitive- Behavioral Therapy (CBT) and Mindfulness-Based Stress Reduction (MBSR)-impact two specific forms of emotion regulation-cognitive regulation (CR) and attention regulation (AR). The clinical context for our proposed study is generalized Social Anxiety Disorder (SAD), a highly prevalent, persistent, and often debilitating psychiatric condition characterized by overwhelming fear and avoidance of social situations. Our proposed research addresses three major aims: Aim 1 examines the efficacy and neural bases of CR and AR in SAD versus HC. Aim 2 investigates the immediate and longer-term impact of CBT versus MBSR for SAD. Aim 3 examines changes in CR and AR and tests whether these changes mediate effects of CBT versus MBSR. Adult patients with SAD will be randomly assigned to CBT, MBSR, or WL and administered assessments (including clinical diagnostic interviews, psychiatric and individual difference questionnaires, and functional neuroimaging of emotional reactivity and emotion regulation during a social evaluation task) at baseline, immediately after treatment, and 6 months post-treatment completion. The broad, long-term objective of this translational research program is to further our understanding of basic emotion regulation mechanisms and to contribute to advances in clinical interventions that will improve the health of individuals suffering from Social Anxiety Disorder (SAD) as well as a range of other anxiety and mood disorders.

描述（由申请人提供）：情绪失调被认为是许多轴I和轴II精神疾病的核心机制。特别是，情绪失调被认为在焦虑和情绪障碍中起着至关重要的作用。越来越多的经验工作开始阐明患有焦虑和情绪障碍的个体情绪失调的神经相关性和行为后遗症。但是，关于焦虑和情绪障碍的社会心理治疗如何影响情绪失调，知之甚少。拟议的研究将通过研究两种社会心理治疗方式认知行为疗法（CBT）和基于正念的压力减轻（MBSR）如何影响两种特定形式的情绪调节认知调节（CR）和注意调节（AR）的两种特定形式的形式，直接在我们的知识中直接解决这一差距。我们拟议的研究的临床背景是普遍的社交焦虑症（SAD），这是一种高度普遍，持久，常常使人衰弱的精神病病，其特征是压倒性的恐惧和避免社交情况。我们提出的研究涉及三个主要目的：AIM 1检查了SAD与HC中CR和AR的功效和神经碱基。 AIM 2调查了CBT与MBSR对SAD的直接和长期影响。 AIM 3检查了CR和AR的变化，并测试这些变化是否介导了CBT与MBSR的影响。患有SAD的成年患者将随机分配给CBT，MBSR或WL，并进行评估（包括临床诊断访谈，精神病和个人差异问卷，以及在治疗后6个月完成治疗后，在基线后立即完成了在基线的社会评估任务期间情绪反应性和情绪调节的功能性神经成像。这项翻译研究计划的广泛长期目标是进一步了解基本情绪调节机制，并为临床干预措施的进步做出贡献，这些干预措施将改善患有社交焦虑症（SAD）的人的健康以及其他一系列其他焦虑和情绪障碍。