South Africa-Pittsburgh Public Health Genomic Epidemiology Research Training Program (SAPPHGenE)

南非-匹兹堡公共卫生基因组流行病学研究培训计划 (SAPPHGenE)

• 批准号: 9904390
• 负责人: Lee H Harrison
• 金额: $ 23.08万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-26 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9904390
• 关键词: Address; Africa; Antimicrobial Resistance; Bioinformatics; Centers for Disease Control and Prevention (U.S.); Communicable Diseases; Data; Development; Disadvantaged; Discipline; Disease; Disease Outbreaks; Doctor of Philosophy; Epidemiology; Fostering; Generations; Genomics; Goals; Head; Immunization Programs; Institutes; Institution; Laboratories; Lead; Lung diseases; Medicine; Meningitis; Mentors; Mission; Monitor; Morbidity - disease rate; Pneumonia; Public Health; Public Health Practice; Research; Research Personnel; Research Training; Resources; Respiratory Center; Rest; Site; South Africa; South African; Specimen; Training; Training Programs; United States; Universities; Vaccines; antimicrobial resistant pathogen; experience; genomic epidemiology; healthcare community; human pathogen; microbial genomics; mortality; multidisciplinary; pathogen genome; prevent; professor; programs; research in practice; tool; training opportunity; transmission process

ABSTRACT Public health genomics is a burgeoning field that involves the exploitation of the pathogen genome to comprehensively characterize human pathogens. This includes the monitoring of antimicrobial resistance, determining vaccine-preventable burden, monitoring the impact of immunization programs, as well as detecting and controlling healthcare- and community-associated outbreaks and studying transmission dynamics. However, despite the increasing importance of this field, scientific capacity in public health genomics in Africa is limited. To address this problem, we propose to establish the South Africa-Pittsburgh Public Health Genomic Epidemiology Research Training Program (SAPPHGenE) at the University of Pittsburgh (Pitt), a leading research institution in the United States and the National Institute for Communicable Diseases (NICD), a premier national public health reference and research institution in Johannesburg, South Africa. The overall mission of SAPPHGenE is to provide young South African public health and academic investigators from historically-disadvantaged backgrounds with the multidisciplinary tools needed to conduct cutting-edge research on public health genomics. The main focus is research on epidemiology and genomic epidemiology of bacterial causes of pneumonia, other respiratory diseases, and invasive bacterial and fungal diseases, including antimicrobial-resistant pathogens. The Program Directors are Dr. Lee Harrison, Professor of Epidemiology and Medicine and the head of the Microbial Genomic Epidemiology Laboratory at Pitt and Dr. Anne von Gottberg, Section Lead of the laboratory of the Centre for Respiratory Diseases and Meningitis at the NICD. The program includes a multidisciplinary group of experienced mentors at three training sites: Pitt, the Centers for Disease Control and Prevention in Atlanta, and NICD. We will provide a combination of non-degree and post-graduate (masters and PhD) degree training. Degrees will be provided by the University of the Witwatersrand, located 15 kilometers from NICD, and the degree research using South African data and specimens being conducted at the training sites in Atlanta and Pittsburgh. Trainees will have access to substantial research training opportunities and resources that are available at the training sites. The focus will encompass training in genomic epidemiology and bioinformatics, with emphasis on the use of these disciplines in public health. The ultimate goal of the program is to provide local capacity to monitor, prevent, and control our target bacterial and fungal diseases, some of which are vaccine preventable or antimicrobial resistant and all which are major causes of morbidity and mortality in South Africa, the rest of Africa, and globally. The training opportunities described in this application will substantially increase research capacity and foster the development of a generation of public health genomic research mentors in South Africa. Ultimately, we anticipate that NICD will serve as regional training center within Africa for research in and practice of public health genomics in Africa.

抽象的 公共卫生基因组学是一个新兴的领域，涉及将病原体基因组开发为 全面地表征了人类病原体。这包括监测抗菌耐药性， 确定可预防疫苗的负担，监视免疫计划的影响以及检测 并控制医疗保健和社区相关的暴发并研究传播动态。 但是，尽管该领域的重要性越来越重要，但非洲公共卫生基因组学的科学能力 有限。为了解决这个问题，我们建议建立南非匹兹堡公共卫生基因组 匹兹堡大学（PITT）的流行病学研究培训计划（Sapphgene），领先 美国的研究机构和美国国家传染病研究所（NICD）， 南非约翰内斯堡的总理国家公共卫生参考和研究机构。总体 Sapphgene的使命是向南非年轻的公共卫生和学术研究人员提供 历史上偏爱的背景，具有进行尖端的多学科工具 公共卫生基因组学研究。主要重点是有关流行病学和基因组流行病学的研究 肺炎，其他呼吸道疾病以及侵入性细菌和真菌疾病的细菌原因， 包括抗菌病原体。该计划主任是Lee Harrison博士 皮特和博士的流行病学和医学以及微生物基因组流行病学实验室负责人 安妮·冯·戈特伯格（Anne von Gottberg），呼吸道疾病和脑膜炎实验室的负责人 尼克。该计划包括一个在三个培训网站上的多学科导师组的跨学科小组：皮特， 亚特兰大的疾病控制与预防中心和NICD。我们将提供非学位的组合 和研究生（硕士和博士学位）学位培训。学位将由大学提供 Witwatersrand，距离NICD 15公里，使用南非数据和学位研究 在亚特兰大和匹兹堡的培训地点进行标本。学员将可以使用 培训网站可用的大量研究培训机会和资源。重点将 包括基因组流行病学和生物信息学的培训，重点是使用这些学科 在公共卫生方面。该计划的最终目标是提供当地监控，预防和控制的能力 我们的靶标细菌和真菌疾病，其中一些是可预防或抗菌抗药性的疫苗 所有这些都是南非，非洲其他地区以及全球发病率和死亡率的主要原因。这 本应用中描述的培训机会将大大提高研究能力并促进 在南非发展一代公共卫生基因组研究指导者。最终，我们 预计NICD将作为非洲的区域培训中心，以进行公众研究和实践 非洲的健康基因组学。