University of Pittsburgh Training Program in Antimicrobial Resistance

匹兹堡大学抗菌素耐药性培训计划

• 批准号: 10590645
• 负责人: Lee H Harrison
• 金额: $ 26.71万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-16 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590645
• 关键词: Antimicrobial Resistance; Training Programs; Universities

SUMMARY Antimicrobial resistance is one of the most pressing public health issues facing the world today. However, a paucity of local and national training opportunities dedicated to this field creates a critical gap that may impact our current and future ability to tackle antimicrobial resistance. Accordingly, we propose to establish the University of Pittsburgh Training Program in Antimicrobial Resistance (Pitt TPAR), which will train both graduate students and post-doctoral fellows in advanced studies of antimicrobial resistance. Key attributes of our exciting new program include the unparalleled resources and institutional support at the University of Pittsburgh, and the multidisciplinary focus, commitment, experience and funding of our training faculty. Our philosophy is that trainees should receive training that exposes them to a broad spectrum of advanced, cutting edge, and novel approaches used in antimicrobial research to best prepare them to become creative and independent investigators. Therefore, the overall objective of the Pitt TPAR is to provide a collaborative, interdisciplinary, and coordinated team-mentoring effort to trainees from diverse academic backgrounds to foster highly-skilled, independent investigators who have the technical, intellectual and leadership skills that will allow them to make major contributions to the antimicrobial resistance field. This will be accomplished through a co-mentorship structure, with one mentor being a strong content expert in the proposed area of research, with the other(s) to be drawn from a range of disciplines as determined by the area of study. The expertise of our mentors covers fields that are crucial for the comprehensive study of antimicrobial resistance, including i) pathogenesis and molecular mechanisms of resistance, (ii) microbial genomics (iii) the human microbiome, (iv) bioinformatics, (v) epidemiology and biostatistics, and (vi) infectious diseases modeling and simulation. We have designed a unique educational curriculum that will provide core training in antimicrobial resistance, and we will also nurture our trainee's oral and written presentation skills, and help them to establish a scientific network that will advance their career. Collectively, we believe that the Pitt TPAR is unique in that it will leverage concepts in drug resistance from diverse bacterial, fungal and viral systems, with the goal of educating trainees in fundamental concepts of resistance, and enable the utilization of common themes for their research.

概括 抗菌素抵抗是当今世界面临的最紧迫的公共卫生问题之一。但是， 缺乏致力于该领域的本地和国家培训机会会产生一个关键的差距，可能会影响 我们目前和未来应对抗菌耐药性的能力。因此，我们建议建立 匹兹堡大学抗菌抗药性培训计划（Pitt TPAR），该计划将训练两者 研究生和博士后研究员在抗菌素耐药性的高级研究中。关键属性 我们令人兴奋的新计划包括大学的无与伦比的资源和机构支持 匹兹堡以及我们培训学院的多学科重点，承诺，经验和资金。我们的 理念是，学员应该接受培训，使他们暴露于各种各样的先进，切割 边缘和抗菌研究中使用的新颖方法，以最好地使其成为创造力和 独立调查员。因此，Pitt TPAR的总体目标是提供协作， 跨学科和协调团队仪式向来自不同学术背景的学员到 培养具有技术，智力和领导能力的高技能，独立的研究人员 允许他们对抗菌抗性场做出重大贡献。这将通过 一个会议结构，一位导师是拟议研究领域的强大内容专家， 由研究领域确定的一系列学科中得出的另一个（s）。专业知识 我们的导师涵盖了对于包括I在内的抗菌耐药性的全面研究至关重要的领域 电阻的发病机理和分子机制，（ii）微生物基因组学（III）人类微生物组，（iv） 生物信息学，（v）流行病学和生物统计学以及（VI）传染病建模和模拟。我们 已经设计了一种独特的教育课程，该课程将提供抗菌素抵抗的核心培训，并 我们还将培养学员的口头和书面演讲技巧，并帮助他们建立科学 将推进他们职业生涯的网络。总的来说，我们认为Pitt TPAR是独一无二的 利用各种细菌，真菌和病毒系统的耐药性概念，目的 对受训者进行基本的抵抗概念，并能够利用共同的主题 他们的研究。

项目成果

In vivo evolution of a Klebsiella pneumoniae capsule defect promotes complement-mediated opsono-phagocytosis and persistence during recurrent infection.

肺炎克雷伯菌荚膜缺陷的体内进化促进补体介导的调理吞噬作用和复发感染期间的持续存在。

• DOI: 10.1101/2023.05.31.542722
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Bain,William;Ahn,Brian;Peñaloza,HernánF;McElheny,ChristiL;Tolman,Nathanial;vanderGeest,Rick;Gonzalez-Ferrer,Shekina;Chen,Nathalie;An,Xiaojing;Hosuru,Ria;Tabary,Mohammadreza;Papke,Erin;Kohli,Naina;Farooq,Nauman;Bachman,Will
• 通讯作者: Bachman,Will

Clinical Features and Multimodal Imaging in Atypical Posterior Uveitis Secondary to Bartonella Henselae Infection.

汉赛巴尔通体感染继发的非典型后葡萄膜炎的临床特征和多模态成像。

• DOI: 10.1080/09273948.2021.1961812
• 发表时间: 2022
• 期刊: Ocular immunology and inflammation
• 影响因子: 3.3
• 作者: Koretz,ZacharyA;Apostolopoulou,Anna;Chen,Edwin;Beale,Oliver;Veldkamp,Peter;Viehman,JohnAlex;Sahel,José-Alain;Chhablani,Jay;Dansingani,KunalK;Errera,Marie-Hélène;Bonhomme,GabrielleR
• 通讯作者: Bonhomme,GabrielleR

Detection of Influenza virus and Streptococcus pneumoniae in air sampled from co-infected ferrets and analysis of their influence on pathogen stability.

共感染雪貂空气样本中流感病毒和肺炎链球菌的检测及其对病原体稳定性的影响分析。

• DOI: 10.1101/2023.02.24.529988
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: French,AndreaJ;Rockey,NicoleC;Sage,ValerieLe;Brown,KarinaMueller;Shephard,MeredithJ;Frizzell,Sheila;Myerburg,MikeM;Hiller,NLuisa;Lakdawala,SeemaS
• 通讯作者: Lakdawala,SeemaS

Targeted IS-element sequencing uncovers transposition dynamics during selective pressure in enterococci.

• DOI: 10.1371/journal.ppat.1011424
• 发表时间: 2023-06
• 期刊: PLoS pathogens
• 影响因子: 6.7

Convergent Evolution of Antibiotic Tolerance in Patients with Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia.

• DOI: 10.1128/iai.00001-22
• 发表时间: 2022-04-21
• 期刊: Infection and immunity
• 影响因子: 3.1