University of Pittsburgh Training Program in Antimicrobial Resistance

匹兹堡大学抗菌素耐药性培训计划

• 批准号: 10590645
• 负责人: Lee H Harrison
• 金额: $ 26.71万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-16 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590645
• 关键词: Antimicrobial Resistance; Training Programs; Universities

SUMMARY Antimicrobial resistance is one of the most pressing public health issues facing the world today. However, a paucity of local and national training opportunities dedicated to this field creates a critical gap that may impact our current and future ability to tackle antimicrobial resistance. Accordingly, we propose to establish the University of Pittsburgh Training Program in Antimicrobial Resistance (Pitt TPAR), which will train both graduate students and post-doctoral fellows in advanced studies of antimicrobial resistance. Key attributes of our exciting new program include the unparalleled resources and institutional support at the University of Pittsburgh, and the multidisciplinary focus, commitment, experience and funding of our training faculty. Our philosophy is that trainees should receive training that exposes them to a broad spectrum of advanced, cutting edge, and novel approaches used in antimicrobial research to best prepare them to become creative and independent investigators. Therefore, the overall objective of the Pitt TPAR is to provide a collaborative, interdisciplinary, and coordinated team-mentoring effort to trainees from diverse academic backgrounds to foster highly-skilled, independent investigators who have the technical, intellectual and leadership skills that will allow them to make major contributions to the antimicrobial resistance field. This will be accomplished through a co-mentorship structure, with one mentor being a strong content expert in the proposed area of research, with the other(s) to be drawn from a range of disciplines as determined by the area of study. The expertise of our mentors covers fields that are crucial for the comprehensive study of antimicrobial resistance, including i) pathogenesis and molecular mechanisms of resistance, (ii) microbial genomics (iii) the human microbiome, (iv) bioinformatics, (v) epidemiology and biostatistics, and (vi) infectious diseases modeling and simulation. We have designed a unique educational curriculum that will provide core training in antimicrobial resistance, and we will also nurture our trainee's oral and written presentation skills, and help them to establish a scientific network that will advance their career. Collectively, we believe that the Pitt TPAR is unique in that it will leverage concepts in drug resistance from diverse bacterial, fungal and viral systems, with the goal of educating trainees in fundamental concepts of resistance, and enable the utilization of common themes for their research.

概括 抗生素耐药性是当今世界面临的最紧迫的公共卫生问题之一。然而，一个 专门针对该领域的地方和国家培训机会的缺乏造成了一个严重的差距，可能会影响 我们当前和未来解决抗菌素耐药性的能力。因此，我们建议设立 匹兹堡大学抗菌素耐药性培训计划 (Pitt TPAR)，将培训 抗生素耐药性高级研究的研究生和博士后研究员。的关键属性 我们令人兴奋的新计划包括大学无与伦比的资源和机构支持 匹兹堡，以及我们培训教师的多学科关注、承诺、经验和资金。我们的 我们的理念是，学员应该接受培训，让他们接触到广泛的先进、切割技术 抗菌研究中使用的前沿和新颖方法，以最好地准备他们变得富有创造力和 独立调查员。因此，Pitt TPAR 的总体目标是提供一个协作的、 跨学科、协调的团队指导工作，为来自不同学术背景的学员提供指导 培养高技能、独立的调查员，他们具备技术、智力和领导技能， 让他们为抗菌素耐药性领域做出重大贡献。这将通过以下方式完成 共同导师结构，其中一名导师是拟议研究领域的资深内容专家， 其他人则来自由研究领域确定的一系列学科。的专业知识 我们的导师涵盖了对抗菌素耐药性综合研究至关重要的领域，包括 i) 耐药性的发病机制和分子机制，(ii) 微生物基因组学，(iii) 人类微生物组，(iv) 生物信息学，（v）流行病学和生物统计学，以及（vi）传染病建模和模拟。我们 设计了独特的教育课程，提供抗菌素耐药性的核心培训，并且 我们还将培养学员的口头和书面表达能力，并帮助他们建立科学的 网络将促进他们的职业生涯。总的来说，我们相信 Pitt TPAR 是独一无二的，因为它将 利用不同细菌、真菌和病毒系统的耐药性概念，目标是 对学员进行抵抗基本概念的教育，并能够利用共同主题 他们的研究。

项目成果

In vivo evolution of a Klebsiella pneumoniae capsule defect promotes complement-mediated opsono-phagocytosis and persistence during recurrent infection.

肺炎克雷伯菌荚膜缺陷的体内进化促进补体介导的调理吞噬作用和复发感染期间的持续存在。

• DOI: 10.1101/2023.05.31.542722
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Bain,William;Ahn,Brian;Peñaloza,HernánF;McElheny,ChristiL;Tolman,Nathanial;vanderGeest,Rick;Gonzalez-Ferrer,Shekina;Chen,Nathalie;An,Xiaojing;Hosuru,Ria;Tabary,Mohammadreza;Papke,Erin;Kohli,Naina;Farooq,Nauman;Bachman,Will
• 通讯作者: Bachman,Will

Clinical Features and Multimodal Imaging in Atypical Posterior Uveitis Secondary to Bartonella Henselae Infection.

汉赛巴尔通体感染继发的非典型后葡萄膜炎的临床特征和多模态成像。

• DOI: 10.1080/09273948.2021.1961812
• 发表时间: 2022
• 期刊: Ocular immunology and inflammation
• 影响因子: 3.3
• 作者: Koretz,ZacharyA;Apostolopoulou,Anna;Chen,Edwin;Beale,Oliver;Veldkamp,Peter;Viehman,JohnAlex;Sahel,José-Alain;Chhablani,Jay;Dansingani,KunalK;Errera,Marie-Hélène;Bonhomme,GabrielleR
• 通讯作者: Bonhomme,GabrielleR

Detection of Influenza virus and Streptococcus pneumoniae in air sampled from co-infected ferrets and analysis of their influence on pathogen stability.

共感染雪貂空气样本中流感病毒和肺炎链球菌的检测及其对病原体稳定性的影响分析。

• DOI: 10.1101/2023.02.24.529988
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: French,AndreaJ;Rockey,NicoleC;Sage,ValerieLe;Brown,KarinaMueller;Shephard,MeredithJ;Frizzell,Sheila;Myerburg,MikeM;Hiller,NLuisa;Lakdawala,SeemaS
• 通讯作者: Lakdawala,SeemaS

Targeted IS-element sequencing uncovers transposition dynamics during selective pressure in enterococci.

• DOI: 10.1371/journal.ppat.1011424
• 发表时间: 2023-06
• 期刊: PLoS pathogens
• 影响因子: 6.7

Convergent Evolution of Antibiotic Tolerance in Patients with Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia.

• DOI: 10.1128/iai.00001-22
• 发表时间: 2022-04-21
• 期刊: Infection and immunity
• 影响因子: 3.1