2020 Angiotensin GRC/GRS

2020 血管紧张素 GRC/GRS

• 批准号: 9898612
• 负责人: MARIA LUISA Soledad SEQUEIRA-LOPEZ
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9898612
• 关键词: Academia; Address; Adult; Angiotensins; Anniversary; Area; Arizona; Award; Basic Science; Benefits and Risks; Bioinformatics; Blood Vessels; Brain; Cardiovascular Diseases; Cardiovascular Physiology; Cells; Child; Circadian Rhythms; Clinical; Clinical Investigator; Clinical Research; Collaborations; Denmark; Development; Discipline; Disease; Educational workshop; Electrolytes; Embryo; Engineering; Environment; Exposure to; Face; Family; Fostering; Funding; Future; Gender; Genomics; Government; Growth; Health; Homeostasis; Hour; Hypertension; Image; Immune system; Industry; Innate Immune Response; Institutes; International; Kidney Diseases; Lead; Leadership; Liquid substance; Mentors; Mission; Modeling; National Heart, Lung, and Blood Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Natural regeneration; Nervous system structure; Neuroimmunomodulation; Oral; Pathologic Processes; Patients; Peripheral Nervous System; Postdoctoral Fellow; Process; Public Health; Recording of previous events; Regulation; Renal Hypertension; Renal function; Renin-Angiotensin-Aldosterone System; Research; Research Personnel; Running; Schedule; Science; Scientific Advances and Accomplishments; Scientist; Senior Scientist; Series; Signal Pathway; Societies; Solid; Source; Time; Training; Travel; Underrepresented Groups; Underrepresented Minority; United States National Institutes of Health; Universities; Virginia; Woman; blood pressure regulation; burden of illness; career; career development; clinical application; drug discovery; drug testing; epigenomics; genome-wide; graduate student; improved; innovation; interest; meetings; new technology; novel; novel therapeutics; operation; personalized medicine; personalized therapeutic; posters; preservation; programs; role model; symposium; transcriptomics; translational approach; translational scientist; undergraduate student; underrepresented minority student

PROJECT SUMMARY The Renin Angiotensin Aldosterone System (RAAS) is crucial for the regulation of blood pressure and fluid electrolyte homeostasis. In addition, the RAAS is involved in vascular development, regeneration, innate immune responses and the operation of the central and peripheral nervous systems. When the RAAS is deranged, it is often at the center of numerous pathological processes leading to cardiovascular and renal diseases and hypertension. On its 40th anniversary, the 2020 Angiotensin Gordon Research Conference (GRC) will focus on integrating novel technologies, clinical studies and personalized therapeutics to preserve health. Recent intellectual and technological advances on single cell transcriptomics, epigenomics, locus- specific (epi)genomic engineering, genome-wide modelling, imaging, and sophisticated drug discovery and testing are leading to groundbreaking fundamental discoveries which pave the way for personalized medicine. Thus, the GRC will highlight innovations on the RAAS that expand from solid basic research to clinical applications and public health impact. Novel discoveries on neuro-immune mechanisms, higher brain functions, regeneration, circadian rhythms, and the risks and benefits of novel therapeutic strategies targeting the RAAS will also be discussed. The Gordon Research Seminar (GRS) will discuss the RAAS in diseases beyond hypertension, novel signaling pathways, and bioinformatics, and include trainee presentations and mentoring series. The GRS, organized by trainees with support of lead scientists from the associated GRC, is held in conjunction with (during the weekend immediately prior to) the GRC. The GRC/GRS’ aims are to discuss original unpublished research and technical advances on RAAS by a diverse group of basic, clinical and translational investigators at all career levels, foster new collaborations, advance the scientific career of junior investigators-trainees and develop, diversify and sustain a strong scientific workforce. The aims are aligned with the NHLBI and NIDDK missions and the scientific themes that will be covered are of direct relevance to both institutes. The GRC/GRS provide an excellent training and networking environment. To stimulate discussions and explore applications of discoveries from other scientific fields to the RAAS area, we invited internationally recognized experts who have not previously attended the Angiotensin GRC. To nurture interactions between trainees and senior scientists we scheduled: 1) 4 Poster Sessions 2) A Power Hour: open forum to support the professional growth of women by discussing challenges that women face in science 3) A Career Development Session and 4) A Mentee-Mentor Pairing Program. NIH funds requested for this conference will help attract trainees, women and scientists from underrepresented groups which currently have limited opportunities to attend one of the best conferences in their field. Novel advances on the RAAS have the potential to improve substantially the management of adults and children with cardiovascular and renal diseases and reduce the burden of disease in patients, their families and our society.

项目摘要 肾素血管紧张素醛固酮系统（RAAS）对于调节血压和液体至关重要 电解质稳态。此外，RAAS参与了血管发展，再生，先天 免疫反应以及中枢和周围神经系统的运行。当王室是 这是奇怪的，通常是导致心血管和肾脏的众多病理过程的中心 疾病和高血压。在2020年血管紧张素戈登研究会议上，成立40周年 （GRC）将着重于整合新技术，临床研究和个性化治疗以保存 健康。有关单细胞转录组学，表观基因组学，基因座的最新智力和技术进步 - 特定（EPI）基因组工程，全基因组建模，成像和复杂的药物发现以及 测试导致开创性的基本发现为个性化医学铺平道路。 这就是GRC将重点介绍RAA上的创新，这些创新从可靠的基础研究扩展到临床 申请和公共卫生影响。关于神经免疫机制，更高的大脑的新发现 功能，再生，昼夜节律以及针对性的新型治疗策略的风险和好处 RAAS也将进行讨论。戈登研究研讨会（GRS）将讨论疾病中的RAA 除了高血压，新颖的信号通路和生物信息学之外，还包括学员演示和 指导系列。由培训在相关GRC的主要科学家的支持下组织的GRS是 与GRC（在周末之前的周末）一起举行。 GRC/GRS的目标是 讨论原始未发表的研究和技术进步，由一群基本的，临床的潜水 并翻译了各个职业级别的调查人员，培养新的合作，推进了科学生涯 初级调查人员培训并发展，多样化和维持强大的科学劳动力。目的是 与NHLBI和NIDDK任务一致以及将要涵盖的科学主题是直接的 与这两个机构有关。 GRC/GRS提供了出色的培训和网络环境。到 刺激讨论并探索从其他科学领域到RAAS地区的发现的应用，我们 邀请国际认可的专家以前从未参加过血管紧张素GRC。护士 我们安排的学员和高级科学家之间的互动：1）4海报会议2）一个电源时光：开放 通过讨论妇女在科学中面临的挑战3） 职业发展会议和4）指导者配对计划。 NIH资金要求 会议将有助于吸引来自代表性不足团体的培训，妇女和科学家 参加该领域最好的会议之一的机会有限。王室的新颖进步有 有可能改善心血管和肾脏的成人和儿童的管理 疾病并减少患者，家庭和我们社会的疾病燃烧。