Waisman Intellectual and Developmental Disabilities Research Center

韦斯曼智力和发育障碍研究中心

基本信息

批准号：
9544725
负责人：
Qiang Chang
金额：
$ 110.16万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-22 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9544725
关键词：
Address Agriculture Animals Award Behavioral Bioinformatics Biological Biological Response Modifier Therapy Biological Sciences Biomanufacturing Biometry Brain imaging CGG repeat Cell Culture Techniques Child Clinic Clinical Clinical Research Clinical Trials Clinical assessments Cognitive Therapy Communities Consultations Cryopreservation Cyclic GMP Development Diagnostic Services Ecology Educational workshop Electroencephalography Engineering Environment Exposure to FMR1 Faculty Family Fostering Funding Generations Genes Genetic Engineering Genetic Variation Health Health Services Research Home environment Human Human Cell Line Imaging Device Individual Institutes Intellectual functioning disability Intervention Investigation Joints Knowledge Laboratories Language Disorders Length Letters Liquid substance Location Magnetic Resonance Imaging Mental Retardation and Developmental Disabilities Research Centers Mentors Methods Mission Modeling Molecular Mouse Strains National Institute of Child Health and Human Development Neurosciences Nursery Schools Participant Pathogenesis Pathology Pharmacy facility Phenotype Positron-Emission Tomography Prevention Privatization Production Productivity Program Development Public Health Quality of life Rattus Request for Applications Research Research Personnel Research Project Grants Resources Rodent Scanning Schools Science Scientific Advances and Accomplishments Scientist Seasons Series Services Sum System Teacher Professional Development Techniques Technology Therapeutic Training Training Programs Translational Research United States National Institutes of Health Universities Variant Veterinary Medicine Wisconsin base biobehavior collaborative approach college design experience human subject induced pluripotent stem cell innovation instrumentation interdisciplinary collaboration leadership development medical schools meetings method development microPET mutant nervous system development neuroimaging next generation nonhuman primate novel therapeutics post-doctoral training pre-doctoral programs recruit science education special interest group training opportunity translational research program treatment services undergraduate student

项目摘要

We seek continued support of the Waisman Center Intellectual and Developmental Disabilities Research Center, a comprehensive interdisciplinary program focused on IDD spanning the biological, biobehavioral, and bio-behavioral sciences. The Waisman IDDRC brings together 46 PIs from 21 academic departments from the UW-Madison's Schools of Medicine and Public Health, Veterinary Medicine, Pharmacy, Agriculture and Life Sciences, Letters and Science, Education, Engineering, and Human Ecology. This application requests support for an Administrative Core (Core A), providing scientific leadership, program and faculty development, facilitation of interdisciplinary collaboration, and biostatistical and bioinformatics expertise; and three innovative scientific core services: Clinical Translational (Core B), providing services, resources, and training in the recruitment of human participants, clinical assessment, behavioral methods development, and cGMP biomanufacturing of therapeutics; Brain Imaging (Core C), providing access to state-of-the-art neuroimaging instrumentation (3T MRI, PET, and microPET scanners for human, non-human primate, and rodent scanning, and an EEG recording system), as well as expertise and tools for image acquisition and analysis; and IDD Models (Core D), providing resources, expertise, and technical services in the generation and characterization of mutant or genetically engineered strains of mice and rats, the generation of induced pluripotent stem cell lines from humans with IDD conditions, and facilities for phenotypic characterization of these models using molecular, cellular and behavioral technologies. In addition, we request support for a Research Project that is focused on the impact of variations in CGG repeat length in the FMR1 gene on health and function at the cellular through organismal level, using both cell culture models and human subjects. We propose to provide core support to 79 research projects headed by 46 PIs addressing three broad themes relevant to IDD: 1) nervous system development and pathogenesis, 2) IDD conditions, and 3) assessment, interventions, and therapeutics. Collectively the core services and the research project of the Waisman Center IDDRC will stimulate new interdisciplinary IDD research and enhance existing IDD investigations sharpening our focus on discovery, prevention, and treatment for IDD conditions, and improvement of the quality of life of individuals with IDD and their families.

我们寻求魏斯曼智力和发育障碍研究中心的持续支持中心，一个综合性跨学科项目，专注于 IDD，涵盖生物学、生物行为学和生物行为科学。 Waisman IDDRC 汇集了来自 21 个学术部门的 46 名 PI 威斯康辛大学麦迪逊分校医学与公共卫生学院、兽医学院、药学院、农业与生活学院科学、文学和科学、教育、工程和人类生态学。本申请要求支持行政核心（核心A），提供科学领导、项目和教师发展，促进跨学科合作以及生物统计和生物信息学专业知识；以及三个创新科学核心服务：临床转化（核心 B），提供相关领域的服务、资源和培训人类参与者的招募、临床评估、行为方法开发和 cGMP 治疗药物的生物制造；脑成像（核心 C），提供最先进的神经成像仪器（用于人类、非人类灵长类动物和啮齿动物扫描的 3T MRI、PET 和 microPET 扫描仪，和脑电图记录系统），以及图像采集和分析的专业知识和工具；和国际直拨电话模型（核心 D），在生成和表征方面提供资源、专业知识和技术服务突变或基因工程小鼠和大鼠品系，诱导多能干细胞的产生来自患有 IDD 条件的人类的品系，以及使用这些模型进行表型表征的设施分子、细胞和行为技术。此外，我们请求支持一个研究项目，该项目是重点关注 FMR1 基因中 CGG 重复长度的变化对健康和功能的影响使用细胞培养模型和人类受试者在有机体水平上进行细胞研究。我们建议为 46 名 PI 领导的 79 个研究项目提供核心支持，涉及三大主题与 IDD 相关：1) 神经系统发育和发病机制，2) IDD 状况，以及 3) 评估，干预和治疗。魏斯曼中心核心服务和研究项目的统称 IDDRC 将刺激新的跨学科 IDD 研究并加强现有 IDD 调查我们专注于 IDD 病症的发现、预防和治疗，以及改善人们的生活质量 IDD 患者及其家人。