Biological mechanisms of risk and resiliency in brain aging among ethnic minorities

少数民族大脑衰老风险和弹性的生物学机制

• 批准号: 9768544
• 负责人: ROBERT C. WELSH
• 金额: $ 7.7万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-22 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9768544
• 关键词: Address; Affect; Age; Aging; Alzheimer' s Disease; Area; Biological; Brain; Brain imaging; Caucasians; Cerebrovascular Disorders; Cities; Cognition; Cognitive; Collaborations; Communities; DNA Methylation; Data; Dementia; Diffusion; Disease; Elderly; Epigenetic Process; Exercise; Foundations; Funding Opportunities; Future; Genetic; Goals; Gold; Habits; Health; Healthcare; Hispanic Americans; Hispanics; Human; Image; Impaired cognition; Intervention; Laboratories; Lead; Life Expectancy; Life Style; Magnetic Resonance Imaging; Measures; Mexican Americans; Minority Groups; Minority Participation; Neurodegenerative Disorders; Older Population; Participant; Perfusion; Persons; Population; Preventive Intervention; Process; Protocols documentation; Research; Research Personnel; Risk; Risk Factors; Sodium Chloride; Stroke; Structure; Techniques; Trust; United States; United States National Institutes of Health; Universities; University resources; Utah; Work; aging brain; brain health; connectome; diabetes risk; disorder risk; ethnic minority population; experience; genetic analysis; health care availability; health disparity; innovation; low socioeconomic status; member; metropolitan; minority communities; minority health; neuroimaging; nutrition; patient engagement; pre-clinical; recruit; resilience; social; socioeconomics; success; tool

Abstract Minority health disparities have been well documented in the United States. These disparities exist in the domains of access to healthcare and participation in health research. Ethnic minorities in the United States also have increased risk of cardio- and cerebrovascular disease, stroke, and dementia. It is also known that lifestyle differences (such as exercise and nutrition habits), lower socioeconomic status, and diabetes are risk factors. With the increasing proportion of ethnic minorities in the United States, it is imperative to better understand disease processes that have historically been studied in Caucasian populations. The proportion of elderly that are Hispanic is expected to double, or even triple, in the coming decades. With an increasing population fraction, and increasing life expectancy, it is projected that upwards of a 6-fold increase in Alzheimer's disease will occur in Hispanics. Establishing the trust and partnership between Hispanic communities and world-class researchers is paramount to enable large-scale studies in order to diminish the disparity in minority health research. Our goal is to establish a collaborative foundation between the local minority communities and our research group at the University of Utah. This foundation will greatly facilitate ethnic minority participation in state-of-the-art genetic analysis, such as the newly developed technique of epigenetic aging, and advanced brain imaging research. Succeeding in this goal will allow us to begin to understand the specific risk and resiliency factors related to brain aging in the Hispanic community. The scope of the current project will establish a partnership between local Hispanic communities (approximately 75% Mexican-American) in the Salt Lake City region, neuroimaging researchers at the University of Utah, and collaborators at UCLA. The project will leverage existing university resources, such as the Community/Patient Engagement Studio, to bring the project team members, community stakeholders, and communities in an equal partnership to establish the foundation to perform state-of- the-art genetic and neuroimaging research. The project will synergistically work with local communities to reduce barriers for participation in research. Success of this project will open up avenues that will lead to large-scale studies utilizing cutting edge genetic (epigenetic aging), and neuroimaging techniques that have been applied in studies of Caucasians related to brain aging and Alzheimer's. Utilization of these advanced tools will allow for much-needed research into early signs of brain risk, as well as resiliency, in the Hispanic population. The derived engagement and recruitment strategies, along with these data will form the basis of a future, large-scale study to examine the Alzheimer's disease process in Hispanic-Americans.

抽象的 少数民族健康差异在美国已经有充分的记录。这些差异存在 获得医疗保健和参与健康研究的领域。曼联的少数民族 各州还增加了心脏和脑血管疾病，中风和痴呆症的风险。也是 知道生活方式差异（例如运动和营养习惯），较低的社会经济地位和 糖尿病是危险因素。随着美国少数民族比例的增加，这是 必须更好地了解在白种人中研究的疾病过程 人群。西班牙裔老人比例将在 未来几十年。随着人口分数的增加和预期寿命的增加，它被预测 在西班牙裔人中，阿尔茨海默氏病增加了6倍以上。建立信任 西班牙裔社区与世界一流的研究人员之间的伙伴关系至关重要 大规模研究是为了减少少数民族健康研究的差异。我们的目标是建立 当地少数民族社区与我们的研究小组之间的合作基础 犹他大学。该基金会将极大地促进少数民族参与最先进的 遗传分析，例如新开发的表观遗传衰老技术和晚期大脑 成像研究。成功实现这一目标将使我们能够开始了解特定的风险和 与西班牙裔社区中脑衰老有关的弹性因素。 当前项目的范围将建立当地西班牙裔社区之间的伙伴关系 （约75％墨西哥裔美国人）在盐湖城地区，神经影像学研究人员 犹他大学，加州大学洛杉矶分校的合作者。该项目将利用现有的大学资源， 例如社区/患者参与工作室，为项目团队成员，社区带来 利益相关者和与平等伙伴关系的社区建立基础，以执行最新状态 艺术遗传和神经影像学研究。该项目将与当地社区协同合作 减少参与研究的障碍。 该项目的成功将开放途径，这将导致利用最先进的大规模研究 遗传（表观遗传衰老）和神经影像学技术已应用于研究 高加索人与大脑衰老和阿尔茨海默氏症有关。这些高级工具的利用将允许 在西班牙裔人群中，急需的研究对脑风险以及弹性的早期迹象。 派生的参与和招聘策略以及这些数据将构成 未来的大规模研究，以研究西班牙裔美国人中的阿尔茨海默氏病过程。