Biological mechanisms of risk and resiliency in brain aging among ethnic minorities

少数民族大脑衰老风险和弹性的生物学机制

• 批准号: 9768544
• 负责人: ROBERT C. WELSH
• 金额: $ 7.7万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-22 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9768544
• 关键词: Address; Affect; Age; Aging; Alzheimer' s Disease; Area; Biological; Brain; Brain imaging; Caucasians; Cerebrovascular Disorders; Cities; Cognition; Cognitive; Collaborations; Communities; DNA Methylation; Data; Dementia; Diffusion; Disease; Elderly; Epigenetic Process; Exercise; Foundations; Funding Opportunities; Future; Genetic; Goals; Gold; Habits; Health; Healthcare; Hispanic Americans; Hispanics; Human; Image; Impaired cognition; Intervention; Laboratories; Lead; Life Expectancy; Life Style; Magnetic Resonance Imaging; Measures; Mexican Americans; Minority Groups; Minority Participation; Neurodegenerative Disorders; Older Population; Participant; Perfusion; Persons; Population; Preventive Intervention; Process; Protocols documentation; Research; Research Personnel; Risk; Risk Factors; Sodium Chloride; Stroke; Structure; Techniques; Trust; United States; United States National Institutes of Health; Universities; University resources; Utah; Work; aging brain; brain health; connectome; diabetes risk; disorder risk; ethnic minority population; experience; genetic analysis; health care availability; health disparity; innovation; low socioeconomic status; member; metropolitan; minority communities; minority health; neuroimaging; nutrition; patient engagement; pre-clinical; recruit; resilience; social; socioeconomics; success; tool

Abstract Minority health disparities have been well documented in the United States. These disparities exist in the domains of access to healthcare and participation in health research. Ethnic minorities in the United States also have increased risk of cardio- and cerebrovascular disease, stroke, and dementia. It is also known that lifestyle differences (such as exercise and nutrition habits), lower socioeconomic status, and diabetes are risk factors. With the increasing proportion of ethnic minorities in the United States, it is imperative to better understand disease processes that have historically been studied in Caucasian populations. The proportion of elderly that are Hispanic is expected to double, or even triple, in the coming decades. With an increasing population fraction, and increasing life expectancy, it is projected that upwards of a 6-fold increase in Alzheimer's disease will occur in Hispanics. Establishing the trust and partnership between Hispanic communities and world-class researchers is paramount to enable large-scale studies in order to diminish the disparity in minority health research. Our goal is to establish a collaborative foundation between the local minority communities and our research group at the University of Utah. This foundation will greatly facilitate ethnic minority participation in state-of-the-art genetic analysis, such as the newly developed technique of epigenetic aging, and advanced brain imaging research. Succeeding in this goal will allow us to begin to understand the specific risk and resiliency factors related to brain aging in the Hispanic community. The scope of the current project will establish a partnership between local Hispanic communities (approximately 75% Mexican-American) in the Salt Lake City region, neuroimaging researchers at the University of Utah, and collaborators at UCLA. The project will leverage existing university resources, such as the Community/Patient Engagement Studio, to bring the project team members, community stakeholders, and communities in an equal partnership to establish the foundation to perform state-of- the-art genetic and neuroimaging research. The project will synergistically work with local communities to reduce barriers for participation in research. Success of this project will open up avenues that will lead to large-scale studies utilizing cutting edge genetic (epigenetic aging), and neuroimaging techniques that have been applied in studies of Caucasians related to brain aging and Alzheimer's. Utilization of these advanced tools will allow for much-needed research into early signs of brain risk, as well as resiliency, in the Hispanic population. The derived engagement and recruitment strategies, along with these data will form the basis of a future, large-scale study to examine the Alzheimer's disease process in Hispanic-Americans.

抽象的 在美国，少数民族的健康差异已得到充分记录。这些差异存在于 获得医疗保健和参与健康研究的领域。联合国的少数族裔 各州患心脑血管疾病、中风和痴呆的风险也有所增加。这也是 已知生活方式差异（例如锻炼和营养习惯）、较低的社会经济地位以及 糖尿病是危险因素。随着美国少数族裔比例的不断增加 迫切需要更好地了解历史上在高加索人中研究过的疾病过程 人口。西班牙裔老年人的比例预计将增加一倍甚至三倍 未来几十年。随着人口比例的增加和预期寿命的延长，预计 西班牙裔中阿尔茨海默病的发病率将增加 6 倍以上。建立信任 西班牙裔社区和世界一流研究人员之间的合作对于实现这一目标至关重要 大规模研究，以缩小少数群体健康研究中的差异。我们的目标是建立 当地少数民族社区和我们的研究小组之间的合作基础 犹他大学。该基金会将极大地促进少数民族参与最先进的技术 遗传分析，例如新开发的表观遗传衰老技术和先进的大脑 影像学研究。成功实现这一目标将使我们能够开始了解具体的风险和 与西班牙裔社区大脑衰老相关的弹性因素。 当前项目的范围将在当地西班牙裔社区之间建立伙伴关系 （大约 75% 是墨西哥裔美国人）在盐湖城地区，神经影像学研究人员 犹他大学和加州大学洛杉矶分校的合作者。该项目将利用现有的大学资源， 例如社区/患者参与工作室，让项目团队成员、社区 利益相关者和社区建立平等伙伴关系，为执行现状奠定基础 最先进的遗传和神经影像研究。该项目将与当地社区协同合作 减少参与研究的障碍。 该项目的成功将为利用尖端技术进行大规模研究开辟途径 遗传（表观遗传衰老）和神经影像技术已应用于研究 白种人与大脑衰老和阿尔茨海默氏症有关。利用这些先进的工具将允许 急需对西班牙裔人群的大脑风险早期迹象以及恢复能力进行研究。 得出的参与和招聘策略以及这些数据将构成 未来将进行大规模研究，以检查西班牙裔美国人的阿尔茨海默病过程。