Cortex Changes in Real/Imagined Movement in ALS

ALS 患者真实/想象运动中的皮质变化

基本信息

批准号：
7879277
负责人：
ROBERT C. WELSH
金额：
$ 33.16万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-30 至 2013-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7879277
关键词：
Activities of Daily Living Affect Age Algorithms Amyotrophic Lateral Sclerosis Anisotropy Area Arts Atrophic Biomedical Engineering Brain Brain Mapping Brain Stem Infarctions Brain region Cerebral Palsy Cessation of life Cognition Cognitive Communication Communication Aids for Disabled Computers Cross-Sectional Studies Data Data Set Degenerative Disorder Detection Development Devices Diagnosis Diffuse Diffusion Magnetic Resonance Imaging Disease Disease Progression Educational workshop Electrodes Electroencephalography Elements Exhibits Eye Movements Fingers Functional Magnetic Resonance Imaging Human Human Characteristics Imagery Imaging Techniques Impairment Implant Implanted Electrodes Individual Individual Differences International Knowledge Lead Leg Life Limb structure Location Locked-In Syndrome Longevity Longitudinal Studies Magnetic Resonance Imaging Maps Masks Measures Medical Imaging Methods Monitor Motor Motor Cortex Motor Neurons Motor Pathways Movement Nature Neuraxis Neurologic Newly Diagnosed Operative Surgical Procedures Pathway interactions Patients Pattern Persons Physiological Plastics Population Process Production Progressive Disease Prosthesis Quadriplegia Research Research Personnel Respiratory Failure Rest Self Determination Self-Help Devices Series Signal Transduction Sorting - Cell Movement Source Specificity Spinal Spinal cord injury Staging System Technology Thinking Time Variant Wheelchairs base brain computer interface cohort design disability experience improved interest meetings motor control neuromuscular operation premature relating to nervous system research study restoration tool

项目摘要

DESCRIPTION (provided by applicant): A severe physical disability has a dramatic impact on a person's life, whether it is caused by a neuro-degenerative disease such as amyotrophic lateral sclerosis (ALS), a brainstem stroke, or a spinal cord injury. Someone with these conditions may be effectively "locked-in," retaining their cognitive ability, but unable to perform any movement except possibly the most basic eye movements. Among people with such disabilities, there is a keen interest in technology that can be operated "just by thinking." Short of a cure for the particular condition causing their disability, technology of this type, called a brain-computer interface (BCI), is the best option for restoration of function. A BCI could be used to operate a communication device, wheelchair, or a prosthetic limb. For someone who is locked-in, such technology may offer the only option for communication and self-determination, while for someone with ALS, it would provide a desirable alternative method of control that could potentially be retained as other functional abilities deteriorate. Operation of a BCI would rely on detection and processing of voluntary brain activity such as the ability to attempt or imagine movements such as tapping a finger, or moving a leg, brain activity that survives the condition resulting in the disability. However, the affect of ALS progression on the cortical areas that produce this brain activity is not well understood. The proposed research will use neuro-imaging techniques to map and longitudinally study regions of cortex in persons with ALS that could provide controls signals for a BCI. Using functional magnetic resonance imaging (fMRI) in conjunction with a series of motor control experiments over a period of several years we will longitudinally map brain activation patterns to examine functional stability, atrophy and plasticity. By using state of the art medical imaging, this project will further the understanding of amyotrophic lateral sclerosis (ALS), also commonly known as "Lou Gehrig's Disease", and the disease's effect on the human brain and central nervous system. This knowledge will contribute to the biomedical engineering effort to build devices to allow people with ALS to directly control computers and assistive technologies with their brains.

描述（由申请人提供）：严重的身体残疾会对人的生活产生巨大影响，无论是由肌萎缩侧索硬化症（ALS）、脑干中风还是脊髓损伤等神经退行性疾病引起的。患有这些疾病的人可能会被有效地“锁定”，保留他们的认知能力，但除了可能最基本的眼球运动之外无法进行任何运动。在此类残疾人中，对“只需思考”即可操作的技术有着浓厚的兴趣。由于无法治愈导致其残疾的特定病症，这种称为脑机接口（BCI）的技术是恢复功能的最佳选择。脑机接口可用于操作通信设备、轮椅或假肢。对于被锁定的人来说，这种技术可能提供沟通和自我决定的唯一选择，而对于患有 ALS 的人来说，它将提供一种理想的替代控制方法，随着其他功能能力的恶化，这种方法可能会被保留。脑机接口的操作将依赖于对自愿大脑活动的检测和处理，例如尝试或想象诸如敲击手指或移动腿之类的动作的能力，以及在导致残疾的情况下幸存下来的大脑活动。然而，ALS 进展对产生这种大脑活动的皮质区域的影响尚不清楚。拟议的研究将使用神经成像技术来绘制和纵向研究 ALS 患者的皮质区域，这些区域可以为 BCI 提供控制信号。通过使用功能磁共振成像 (fMRI) 与历时数年的一系列运动控制实验，我们将纵向绘制大脑激活模式图，以检查功能稳定性、萎缩和可塑性。通过使用最先进的医学成像，该项目将进一步了解肌萎缩侧索硬化症（ALS）（通常也称为“卢伽雷氏病”）以及该疾病对人类大脑和中枢神经系统的影响。这些知识将有助于生物医学工程的努力，以构建设备，让 ALS 患者能够用大脑直接控制计算机和辅助技术。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder.

DOI：
10.1017/s0033291715002615
发表时间：
2016-04
期刊：
Psychological medicine
影响因子：
6.9
作者：
Jacobs RH;Barba A;Gowins JR;Klumpp H;Jenkins LM;Mickey BJ;Ajilore O;Peciña M;Sikora M;Ryan KA;Hsu DT;Welsh RC;Zubieta JK;Phan KL;Langenecker SA
通讯作者：
Langenecker SA

25 years of neuroimaging in amyotrophic lateral sclerosis.

DOI：
10.1038/nrneurol.2013.153
发表时间：
2013-09
期刊：
Nature reviews. Neurology
影响因子：
0
作者：
通讯作者：

Action processing and mirror neuron function in patients with amyotrophic lateral sclerosis: an fMRI study.

DOI：
10.1371/journal.pone.0119862
发表时间：
2015
期刊：
PloS one
影响因子：
3.7
作者：
Jelsone-Swain L;Persad C;Burkard D;Welsh RC
通讯作者：
Welsh RC

The utility of independent component analysis and machine learning in the identification of the amyotrophic lateral sclerosis diseased brain.

DOI：
10.3389/fnhum.2013.00251
发表时间：
2013
期刊：
Frontiers in human neuroscience
影响因子：
2.9
作者：
Welsh RC;Jelsone-Swain LM;Foerster BR
通讯作者：
Foerster BR

Longitudinal surface-based spatial Bayesian GLM reveals complex trajectories of motor neurodegeneration in ALS.

DOI：
10.1016/j.neuroimage.2022.119180
发表时间：
2022-07-15
期刊：
NEUROIMAGE
影响因子：
5.7
作者：
Mejia, Amanda F.;Koppelmans, Vincent;Jelsone-Swain, Laura;Kalra, Sanjay;Welsh, Robert C.
通讯作者：
Welsh, Robert C.