Zero Echo Time Imaging of Knee Joint

膝关节零回波时间成像

• 批准号: 9893211
• 负责人: Ravinder Regatte
• 金额: $ 18.65万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9893211
• 关键词: 3-Dimensional; Affect; Biochemical; Biochemical Markers; Biological Models; Biomechanics; Cartilage; Cattle; Clinical; Collagen; Computer software; Degenerative polyarthritis; Development; Diagnosis; Disease; Disease Progression; Extracellular Matrix; Fatty acid glycerol esters; Fourier Transform; Future; Goals; Health; Histology; Human; Hyaline Cartilage; Hydration status; Image; Joints; Knee joint; Ligaments; Magnetic Resonance Imaging; Meniscus structure of joint; Methods; Minor; Modeling; Morphology; Musculoskeletal; Performance; Physiologic pulse; Play; Proteoglycan; Protons; Quantitative Evaluations; Radial; Relaxation; Reporting; Research; Research Personnel; Role; Sampling; Scanning; Signal Transduction; Solid; Structure; Techniques; Technology; Tendon structure; Testing; Time; Tissues; Translating; United States; Validation; Variant; Water; articular cartilage; base; bone; calcification; data space; healthy volunteer; image reconstruction; improved; in vivo; joint destruction; macromolecule; non-invasive imaging; novel; phantom model; radio frequency; skeletal disorder

PROJECT SUMMARY Human knee joints are composed of many different tissues including articular cartilage, calcified cartilage, menisci, ligaments, tendons and bone all of which are important for the health of the joint. Recent research suggests that osteoarthritis (OA) is not just a disease of hyaline cartilage, but rather of the entire joint. Several researchers have demonstrated that the T1ρ relaxation time is more sensitive to proteoglycan (PG) content of the cartilage, while T2 relaxation time is more sensitive to collagen orientation, integrity of network and hydration. The short T1ρ menisci, calcified cartilage, tendons, and ligaments are integral part of joint biomechanics and abnormalities in these tissues may impact joint degeneration and onset of OA. Therefore, quantitative evaluation of relaxation times in these tissues may provide sensitive biochemical markers for early OA diagnosis, and disease progression. However, conventional T1ρ-MRI sequences (e.g., GRE and FSE readouts) are limited value in detecting early macromolecular changes in semi-solid short T1ρ tissues or tissue components such as menisci, ligaments and tendons. Most of the knee joint structures, including menisci, ligaments and tendons have both dominant short (bound/restricted water associated with collagen and/or proteoglycans) and minor long (less restricted/free water associated with macromolecules) components. Therefore, there is a significant need for reliable, non-invasive, time efficient, ZTE-based biexponential 3D-T1ρ imaging sequence for quantitative assessment of semi-solid structures in the knee joint that could detect the early biochemical changes in extracellular matrix (ECM) with short and long relaxation components and their corresponding fractions. The overarching goal of this R21 proposal is to develop, optimize, and translate ZTE (PETRA)-based biexponential 3D-T1ρ imaging pulse sequence for improved quantitative assessment of morphological and biochemical characterization of semi-solid short T1ρ structures in the knee joint (menisci, ligaments and tendons) on a standard clinical 3T scanner employing multicoil compressed sensing (CS).

项目摘要 人膝关节由许多不同的组织组成，包括关节软骨，钙软骨， 半月板，韧带，肌腱和骨骼对关节健康都很重要。最近的研究 表明骨关节炎（OA）不仅是一种透明软骨疾病，而且是整个关节。一些 研究人员表明，T1ρ松弛时间对蛋白聚糖（PG）含量更敏感 软骨，而T2放松时间对胶原方向，网络的完整性和 水合。短的T1ρMenisci，钙化软骨，肌腱和韧带是关节不可或缺的一部分 这些组织中的生物力学和异常可能会影响OA的关节变性和发作。所以， 在这些时间中对松弛时间的定量评估可能会为早期提供敏感的生化标记 OA诊断和疾病进展。但是，常规的T1ρ-MRI序列（例如GRE和FSE 读数）在检测半固体短T1ρ组织或组织的早期大分子变化方面的价值有限 半月板，韧带和肌腱等成分。大多数膝关节结构，包括弯面术， 韧带和肌腱都具有主要的短（与胶原蛋白和/或相关的绑定/受限水 蛋白聚糖）和次要长（与大分子相关的限制/游离水）成分。 因此，非常需要可靠，非侵入性的，时间效率，基于ZTE的Biexpential 3D-T1ρ 对膝关节中半固体结构进行定量评估的成像序列，可以检测到 较短和长的松弛成分及其的早期生化变化（ECM）的生化变化及其 相应的分数。 该R21提案的总体目标是开发，优化和翻译基于中兴通讯（PETRA） Biexpenential 3D-T1ρ成像脉冲序列，以改善形态学和形态学的定量评估 膝关节中半固体短T1ρ结构的生化表征（banisci，韧带和 肌腱）在使用多层压缩灵敏度（CS）的标准临床3T扫描仪上。