Zero Echo Time Imaging of Knee Joint

膝关节零回波时间成像

• 批准号: 9893211
• 负责人: Ravinder Regatte
• 金额: $ 18.65万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9893211
• 关键词: 3-Dimensional; Affect; Biochemical; Biochemical Markers; Biological Models; Biomechanics; Cartilage; Cattle; Clinical; Collagen; Computer software; Degenerative polyarthritis; Development; Diagnosis; Disease; Disease Progression; Extracellular Matrix; Fatty acid glycerol esters; Fourier Transform; Future; Goals; Health; Histology; Human; Hyaline Cartilage; Hydration status; Image; Joints; Knee joint; Ligaments; Magnetic Resonance Imaging; Meniscus structure of joint; Methods; Minor; Modeling; Morphology; Musculoskeletal; Performance; Physiologic pulse; Play; Proteoglycan; Protons; Quantitative Evaluations; Radial; Relaxation; Reporting; Research; Research Personnel; Role; Sampling; Scanning; Signal Transduction; Solid; Structure; Techniques; Technology; Tendon structure; Testing; Time; Tissues; Translating; United States; Validation; Variant; Water; articular cartilage; base; bone; calcification; data space; healthy volunteer; image reconstruction; improved; in vivo; joint destruction; macromolecule; non-invasive imaging; novel; phantom model; radio frequency; skeletal disorder

PROJECT SUMMARY Human knee joints are composed of many different tissues including articular cartilage, calcified cartilage, menisci, ligaments, tendons and bone all of which are important for the health of the joint. Recent research suggests that osteoarthritis (OA) is not just a disease of hyaline cartilage, but rather of the entire joint. Several researchers have demonstrated that the T1ρ relaxation time is more sensitive to proteoglycan (PG) content of the cartilage, while T2 relaxation time is more sensitive to collagen orientation, integrity of network and hydration. The short T1ρ menisci, calcified cartilage, tendons, and ligaments are integral part of joint biomechanics and abnormalities in these tissues may impact joint degeneration and onset of OA. Therefore, quantitative evaluation of relaxation times in these tissues may provide sensitive biochemical markers for early OA diagnosis, and disease progression. However, conventional T1ρ-MRI sequences (e.g., GRE and FSE readouts) are limited value in detecting early macromolecular changes in semi-solid short T1ρ tissues or tissue components such as menisci, ligaments and tendons. Most of the knee joint structures, including menisci, ligaments and tendons have both dominant short (bound/restricted water associated with collagen and/or proteoglycans) and minor long (less restricted/free water associated with macromolecules) components. Therefore, there is a significant need for reliable, non-invasive, time efficient, ZTE-based biexponential 3D-T1ρ imaging sequence for quantitative assessment of semi-solid structures in the knee joint that could detect the early biochemical changes in extracellular matrix (ECM) with short and long relaxation components and their corresponding fractions. The overarching goal of this R21 proposal is to develop, optimize, and translate ZTE (PETRA)-based biexponential 3D-T1ρ imaging pulse sequence for improved quantitative assessment of morphological and biochemical characterization of semi-solid short T1ρ structures in the knee joint (menisci, ligaments and tendons) on a standard clinical 3T scanner employing multicoil compressed sensing (CS).

项目概要 人体膝关节由多种不同组织组成，包括关节软骨、钙化软骨、 半月板、韧带、肌腱和骨骼都对关节的健康很重要。 表明骨关节炎（OA）不仅仅是透明软骨的疾病，而是整个关节的疾病。 研究人员证明，T1ρ 弛豫时间对蛋白聚糖 (PG) 含量更敏感 软骨，而 T2 弛豫时间对胶原蛋白的方向、网络的完整性和 短 T1ρ 半月板、钙化软骨、肌腱和韧带是关节的组成部分。 这些组织的生物力学和异常可能会影响关节退化和 OA 的发病。 对这些组织中弛豫时间的评估可能为早期定量提供敏感的生化标记。 OA 诊断和疾病进展 然而，传统的 T1ρ-MRI 序列（例如 GRE 和 FSE）。 读数）在检测半固体短 T1ρ 组织或组织的早期大分子变化方面价值有限 半月板、韧带和肌腱等大部分膝关节结构，包括半月板、 韧带和肌腱都具有与胶原蛋白和/或相关的主导短水（结合/限制水） 蛋白聚糖）和次要的长组分（与大分子相关的限制较少/自由水）。 因此，非常需要可靠、非侵入性、时间高效、基于 ZTE 的双指数 3D-T1ρ 用于定量评估膝关节半固体结构的成像序列，可以检测 具有短和长松弛成分的细胞外基质（ECM）的早期生化变化及其 相应的分数。 该 R21 提案的总体目标是开发、优化和翻译基于 ZTE (PETRA) 的 双指数 3D-T1ρ 成像脉冲序列，用于改进形态学和 膝关节半固态短 T1ρ 结构（半月板、韧带和 在采用多线圈压缩传感 (CS) 的标准临床 3T 扫描仪上扫描肌腱）。