Imaging Biomarkers of Knee Osteoarthritis

膝骨关节炎的影像生物标志物

基本信息

批准号：
9323286
负责人：
Ravinder Regatte
金额：
$ 62.84万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9323286
关键词：
Affect Biochemical Biological Markers Biological Models Cartilage Chondroitin Sulfates Clinical Clinical Protocols Collagen Collagen Fiber Collagen Type II Communities Data Degenerative polyarthritis Development Disease Disease Progression Early Diagnosis Evaluation Extracellular Matrix Future Goals Healthcare Systems Human Hydration status Image Joints Knee Injuries Knee Osteoarthritis Lead Magnetic Resonance Imaging Maps Measurement Methods Monitor Morphology Multicenter Studies Musculoskeletal Organ Outcome Pain Pathologic Processes Patients Performance Pharmacologic Substance Physiologic pulse Population Proteoglycan Protocols documentation Relaxation Research Research Personnel Risk Sampling Scanning Severity of illness Site Techniques Therapeutic Agents Time Tissue Engineering Tissues Translating Treatment Efficacy Treatment Protocols United States Validation Western Ontario and McMaster Universities Arthritis Index absorption articular cartilage base cartilage degradation clinical research site cohort data space healing high risk high risk population imaging approach imaging biomarker in vivo indexing knee pain macromolecule non-invasive imaging novel personalized medicine premature prevent reconstruction repaired

项目摘要

PROJECT SUMMARY Osteoarthritis (OA) is a degenerative joint disease, affecting more than 27 million people in the United States alone. By 2030 approximately 67 million people will be affected by OA. This large affected population and the severe consequent debility of OA lead to significant expenses to the health care system. OA is characterized by biochemical, structural and morphologic degradation of components of the extracellular matrix (ECM) of articular cartilage. The ECM is composed of primarily two groups of macromolecules including proteoglycan (PG) and collagen fibers. Early diagnosis of cartilage degeneration would require the ability to non-invasively detect changes in PG concentration and collagen integrity before morphological changes occur. T1ρ and T2 relaxation times are affected by these pathological processes and are the most widely used biochemical cartilage MRI sequences worldwide. Several researchers have demonstrated that the T1ρ relaxation time is more sensitive to proteoglycan content of the cartilage, while T2 relaxation time is more sensitive to collagen orientation and integrity of network and hydration. These imaging biomarkers have potential to detect early stages of the disease (pre-clinical), quantitatively assess disease severity, monitor disease progression and possibly monitor OA therapy. The overarching goal of this proposal is to develop, evaluate and translate highly accelerated 3D-T1ρ and T2 mapping (each protocol under 5 minutes) for in-vivo knee OA applications on a standard clinical 3T scanner employing novel compressed sensing (CS) and parallel imaging (PI) strategies. The proposed accelerated 3D- T1ρ and T2 mapping techniques can be easily incorporated into routine clinical protocols for biochemical assessment of cartilage in addition to standard morphological evaluation and could serve as future imaging biomarkers for disease modifying therapies for OA. The outcome of this proposed study will significantly impact our ability for personalized treatment regimens and possibly prevent the development of premature OA. Finally, we intend on disseminating the sequences to other academic sites for widespread implementation and future multicenter studies.

项目概要骨关节炎 (OA) 是一种退行性关节疾病，影响美国超过 2700 万人仅到 2030 年，就有大约 6700 万人受到 OA 的影响。 OA 的严重后果导致医疗保健系统的巨额费用。通过细胞外基质（ECM）成分的生化、结构和形态降解关节软骨主要由两组大分子组成，包括蛋白聚糖。（PG）和胶原纤维的软骨退化的早期诊断需要非侵入性的能力。在 T1ρ 和 T2 发生形态变化之前检测 PG 浓度和胶原完整性的变化。弛豫时间受这些病理过程的影响，是最广泛使用的生化时间世界各地的软骨 MRI 序列几位研究人员已经证明 T1ρ 弛豫时间为对软骨的蛋白多糖含量更敏感，而T2弛豫时间对胶原蛋白更敏感这些成像生物标志物有可能早期检测到网络和水合的方向和完整性。疾病的阶段（临床前），定量评估疾病严重程度，监测疾病进展和可能监测 OA 治疗。该提案的总体目标是开发、评估和翻译高度加速的 3D-T1ρ 和 T2 在标准临床 3T 扫描仪上为体内膝关节 OA 应用进行绘图（每个协议不到 5 分钟）采用新颖的压缩感知（CS）和并行成像（PI）策略所提出的加速3D-。 T1ρ 和 T2 映射技术可以轻松纳入生化的常规临床方案中除了标准形态学评估之外，还可对软骨进行评估，并可作为未来的成像这项拟议研究的结果将对 OA 疾病修饰疗法产生重大影响。我们有能力制定个性化治疗方案，并可能预防过早骨关节炎的发展。我们打算将这些序列传播到其他学术网站，以便广泛实施和未来多中心研究。