UM CFAR SCCC Argentina Consortium for research and training in Virally Induced AIDS Malignancies

UM CFAR SCCC 阿根廷病毒引起的艾滋病恶性肿瘤研究和培训联盟

基本信息

批准号：
9767729
负责人：
Omar Adrian Coso
金额：
$ 67.11万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-20 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9767729
关键词：
AIDS related cancer AIDS/HIV problem Acquired Immunodeficiency Syndrome Address Affect Anus Area Argentina Argentine Award Basic Science Bioinformatics Biological Cancer Center Cancer Etiology Carcinoma Chemoprevention Clinical Clinical Research Country Data Development Diagnosis Epidemiology Epithelial Galactose Binding Lectin Galectin 1 Genomic approach HIV HIV Infections Herpesviridae High Prevalence Human Herpesvirus 4 Human Herpesvirus 8 Human Papillomavirus Human Resources Human papillomavirus 16 Incidence Individual Infrastructure Institution Integration Host Factors Kaposi Sarcoma Knowledge Latin America Lectin Longitudinal cohort Malignant - descriptor Malignant Neoplasms Mediating Mentors Molecular Molecular Epidemiology Molecular Genetics Oncogenic Oncornaviruses PTGS2 gene Papillomavirus Polysaccharides Population Premalignant Prevention Professional Competence Regulation Research Research Personnel Research Project Grants Research Support Research Training Resource Development Resource Sharing Resources Risk Role Sampling Scientist Signal Transduction Training Translational Research Universities Viral Viral Cancer Viral Epidemiology Virus Vulnerable Populations Writing c new cancer genomics cancer type carcinogenesis career career development genetic epidemiology high risk high throughput screening immunoregulation infection risk instrument low and middle-income countries men who have sex with men multidisciplinary new therapeutic target oncology prevent programs prospective repository social vulnerability therapeutic target training opportunity transgender women transmission process tumorigenesis

项目摘要

Around 80% of viral cancers occur in countries with emerging economies such as LMICs. An important subset of virally induced malignancies occurs in the context of HIV/ AIDS (AIDS associated Malignancies/ AM). Latin America have a high prevalence of AIDS-associated Malignancies caused by viruses (including HR-HPV, EBV, KSHV) which tend to disproportionally affect underprivileged and socially vulnerable populations. The current consortium addresses the need of developing research strength in AIDS associated Malignancies while developing a critical mass of independent basic, translational and clinical AIDS-malignancies researchers of Argentina. The current U54 will focus in the career development of junior scientists belonging to an existing consortium of UM CFAR with Argentina Labs through the development of mentored research focusing in the general theme and cancer type of “Basic, translational and Clinical research and training network in virally- induced AIDS-defining malignancies disproportionally affecting Argentina populations with highest risk of HIV/ AIDS”. In the case of Buenos Aires this is both the MSM population with a 11% HIV-infection incidence and the transgender women (TGW) population with an HIV-infection incidence of 37% which are at also the highest risk for infection with oncoviruses KSHV and HR-HPV, and to develop KS and anogenital carcinoma. It will further develop areas emerging from highly complementary and integrated current research of the consortium projects supported by highly tailored Career Enhancement and Shared Resources Cores that will leverage the outstanding research, human resources and infrastructure for HIV/AIDS and viral oncology research available at UM's CFAR, Sylvester Cancer Center, Argentina institutions and the powerful network of Argentine US scientists in USA associated with the consortium. Its components will include an Administrative core, a career enhancement core, a shared resource core and three projects of mentored research that will leverage and enhance the scientific and clinical capacity of the network, generating and leveraging a repository of clinical samples and longitudinal cohort that will enable to correlate clinical findings with molecular/genetic data. Aim 1: To develop research capacity in AM by developing the career of a critical mass of junior researchers in the context of shared resources and scientific networks provided by the consortium institutions. Aim 2: research on “Viral induced AIDS-defining malignancies disproportionally affecting populations in Argentina with the highest risk of HIV/ AIDS” to elucidate molecular and cellular mechanisms of oncogenesis, identify therapeutic targets, prevent cancer, facilitate diagnosis and treatment. P1: Oncogenic signaling networks in AIDS-associated viral cancers as targets of chemoprevention and treatment. P2: Molecular, viral and genetic epidemiology of virally induced AIDS-defining cancers affecting Argentina population with highest risk for HIV infection. P3: Defining the role of lectin-glycan interactions in virally induced AIDS-associated cancers.

大约80％的病毒癌发生在具有LMIC等新兴经济的国家。一个重要的子集实际上引起的恶性肿瘤发生在艾滋病毒/艾滋病的背景下（与艾滋病相关的恶性肿瘤/ am）。拉丁美国患有病毒引起的艾滋病相关的恶性肿瘤患病率很高（包括HR-HPV，EBV， KSHV）往往会过分影响贫困和社会脆弱的人群。电流财团满足了在相关的艾滋病中发展研究实力的必要性开发大量的独立基本，翻译和临床艾滋病 - 纳尔米属研究人员阿根廷。当前的U54将重点放在属于现有的初级科学家的职业发展上 UM CFAR联盟与阿根廷实验室的联盟，通过开发重点的指导研究一般主题和癌症类型的“基本，翻译和临床研究和培训网络” 诱发的艾滋病定义恶性肿瘤不成比例地影响艾滋病毒风险最高艾滋病”。就布宜诺斯艾利斯而言，这既是MSM人口，艾滋病毒感染事件为11％跨性别妇女（TGW）人口的HIV感染事件为37％，这也是最高的 Oncoviruses KSHV和HR-HPV感染的风险，并发展为KS和肛门生殖器癌。会从高度完整和集成的联盟研究中出现的进一步发展领域受量身定制的职业增强和共享资源核心支持的项目，这些核心将利用可用的艾滋病毒/艾滋病和病毒肿瘤研究的杰出研究，人力资源和基础设施可用在UM的CFAR，西尔维斯特癌症中心，阿根廷机构和强大的阿根廷美国网络美国的科学家与财团有关。它的组件将包括行政核心，职业增强核心，共享资源核心和三个修改研究项目，将利用和增强网络的科学和临床能力，产生和利用临床的存储库样品和纵向队列将使临床发现与分子/遗传数据相关。目的1：通过发展大量初级研究人员的职业来发展AM的研究能力财团机构提供的共享资源和科学网络的背景。目标2：研究“病毒诱导的艾滋病定义恶性肿 HIV/ AIDS的最高风险”阐明了肿瘤发生的分子和细胞机制，确定治疗靶标，预防癌症，促进诊断和治疗。 P1：致癌信号网络与艾滋病相关的病毒癌作为化学预防和治疗的靶标。 P2：分子，病毒和遗传影响艾滋病毒风险最高的阿根廷人口的虚拟诱导艾滋病定义癌症的流行病学感染。 P3：定义凝集素 - 聚糖相互作用在实际引起的艾滋病相关癌症中的作用。