NINDS Stroke Trials Network - Regional Coordinating Center

NINDS 中风试验网络 - 区域协调中心

• 批准号: 8739334
• 负责人: Mustapha Ahmad Ezzeddine
• 金额: $ 38万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8739334
• 关键词: Acute; Adult; Affect; African American; Aging; Area; Asians; Caring; Catchment Area; Cause of Death; Censuses; Childhood; Childhood stroke; Clinical; Clinical Management; Clinical Research; Clinical Trials Design; Collaborations; Commit; Complement; County; Critical Care; Data; Dedications; Diagnostic; Discipline; Disease; Effectiveness; Emergency Situation; Emergency treatment; Enrollment; Female; Fostering; Funding; Future; Hispanics; Hospitals; Image; Incubators; Individual; Inpatients; Institution; Interventional radiology; Leadership; Learning; Marketing; Medical; Mentorship; Minnesota; Mission; Modeling; National Institute of Neurological Disorders and Stroke; Native Americans; Neurological emergencies; Neurology; North Dakota; Outcome; Patients; Performance; Phase; Population; Prevention; Prevention education; Principal Investigator; Public Health; Qualifying; Recording of previous events; Recovery; Recruitment Activity; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Resources; Rural; Site; South Dakota; Standardization; Stroke; Study Subject; System; Therapeutic; Time; Training; Translations; Trust; Universities; Wisconsin; Work; clinical research site; demographics; disability; experience; implementation trial; improved; medical schools; medical specialties; member; mortality; nervous system disorder; neurosurgery; organizational structure; pre-clinical; programs; public health relevance; racial and ethnic; success; treatment trial

DESCRIPTION (provided by applicant): Stroke is a common neurological disease and is a growing major public health problem. Although mortality is declining, it remains the number 4 cause of death in the U.S. It is still a major cause of disability, and is expected to significantl grow in number of affected individuals with aging of the population. The mission of NINDS is to reduce the burden of neurological disease, such as stroke. NINDS funded stroke trials have often suffered from long start up time and delays in completing the research. A better way of conducting stroke clinical research on a larger scale is needed. The main objective of this application is to be a Regional Coordinating Stroke Center (RCC) in the NINDS Stroke Trials Network. The purpose of the network is to accelerate and facilitate translation of scientific advancement in stroke treatment, prevention and recovery. Performing such research through the network will introduce a higher degree of efficiency and effectiveness in conducting the trials. The infrastructure to conduct stroke research will not need to be reorganized with every new trial. Trials will be initiated and completed faster. Standardization of clinical and biologica data will also be useful for future work. Enhanced collaboration will result from such a network, and will function as an incubator for trial design. In addition, the network will broaden access to subjects in the acute phase, prevention, and recovery periods. The University of Minnesota and its stroke program are uniquely qualified to serve a Regional Coordinating Center. It has access to a broad set of academic researchers relevant for this field, with depth in various domains of clinical research. It can also draw on the experience of implementing research network, as a current member in the NINDS Neurological Emergency Research Network (NETT). The leaders for this application and of the program are experienced in stroke clinical research, research through networks, and are experts in the subject matter. The various specialties needed to collaborate for successful implementation of the trials are already aligned administratively in collaborative units beyond traditional departments. Overall, the current stroke program at the University of Minnesota is an excellent candidate for leading an RCC.

描述（由申请人提供）：中风是一种常见的神经系统疾病，也是一个日益严重的公共卫生问题。尽管死亡率正在下降，但它仍然是美国第四大死亡原因。它仍然是导致残疾的主要原因，并且预计随着人口老龄化，受影响的人数将显着增加。 NINDS 的使命是减轻中风等神经系统疾病的负担。 NINDS 资助的中风试验常常面临启动时间长和研究完成延迟的问题。需要一种更好的方法来进行更大规模的中风临床研究。该应用程序的主要目标是成为 NINDS 卒中试验网络中的区域卒中协调中心 (RCC)。该网络的目的是加速和促进中风治疗、预防和康复方面科学进步的转化。通过网络进行此类研究将提高试验的效率和有效性。进行中风研究的基础设施不需要在每次新试验中都进行重组。试验将更快地启动和完成。临床和生物学数据的标准化也将对未来的工作有用。这样的网络将加强协作，并将充当试验设计的孵化器。此外，该网络还将扩大访问范围 受试者处于急性期、预防期和恢复期。明尼苏达大学及其卒中项目具有为区域协调中心提供服务的独特资格。它拥有与该领域相关的广泛学术研究人员，在临床研究的各个领域都有深度。它还可以借鉴实施研究网络的经验，作为 NINDS 神经紧急研究网络 (NETT) 的当前成员。该应用程序和该项目的领导者在中风临床研究、网络研究方面经验丰富，并且是该主题的专家。成功实施试验所需的各种专业合作已经在传统部门以外的合作单位中进行了行政协调。总体而言，明尼苏达大学当前的卒中项目是领导 RCC 的绝佳候选者。