Stanford and Northrop Grumman proposal for the Oncology Models Forum

斯坦福大学和诺斯罗普·格鲁曼公司关于肿瘤模型论坛的提案

基本信息

批准号：
9762589
负责人：
ATUL J BUTTE
金额：
$ 91.28万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9762589
关键词：
Address Area Award Bioinformatics Cancer Model Catalogs Communicable Diseases Communities Community Clinical Oncology Program Credentialing Data Data Analyses Databases Diagnostic Disease model Educational workshop Ensure Feedback Funding Funding Mechanisms Future Genetically Engineered Mouse Goals Hour Human Hypersensitivity Immunology Inbred Mouse Institutes Knowledge Learning Malignant Neoplasms Manuscripts Maryland Mission Modeling Mus NIH Program Announcements Nanotechnology National Cancer Institute Nature Online Systems Output Participant Published Comment Publishing Research Research Personnel Resources Role Science Services Site Software Engineering Structure Support Contracts Technology Therapeutic Translations Universities Validation Xenograft procedure biomedical informatics biomedical ontology community building data modeling data sharing design experience human data innovation knowledge base meetings mouse model oncology open source pre-clinical programs public health relevance skills software development success support network technology development tool translational cancer research transplant model tumor web site webinar

项目摘要

DESCRIPTION (provided by applicant): The mission for the Oncology Models Forum (OMF) is to align, harness and integrate data and knowledge of cancer mouse models to drive more rapid success in the discovery of diagnostics, therapeutics, and models of disease in cancer. In early June 2014, the National Cancer Institute (NCI) released PAR-14-239 describing the OMF as a "comprehensive resource for information to guide generating, validating, and credentialing new models, informing their practical uses, advancing modeling technologies, [and] providing catalogs of available models resources, programs, and services." To maximize the use of available resources, this online site was prescribed to use HUBzero, an existing open-source scientific website framework, avoiding the expensive creation of a new scientific website from scratch. The OMF was designed as a community-building tool, with online discussion forums and an annual meeting. Specific content will be provided from the collaborative R01s funded in parallel to the OMF. Pre-clinical mouse and human-in-mouse models are critical to future translation in cancer. More than 4,300 manuscripts were published in 2013 describing or using cancer mouse models, including xenografts and transplantation models, spontaneous models, inbred mice, and genetically engineered mouse models (GEMM). The NCI Cancer Models Database (caMOD) now lists thousands of mouse models that are prone to develop tumors in one or more sites. But data on these models is scattered across numerous resources. Future success in research using cancer mouse models is now less dependent on the continued creation of new models, and more dependent on the validation of the thousands of currently available models, transparent access to knowledge and data on these models, comparisons of model data with human data, and organization of the research community. We plan to develop the Oncology Models Forum (OMF) to accomplish these goals. Our proposed OMF will integrate structured and unstructured data and knowledge on cancer mouse models, enabling new discoveries and the development of new translational tools.

描述（由适用提供）：肿瘤学模型论坛（OMF）的任务是对齐，线束和综合数据以及癌症小鼠模型的知识，以在发现诊断，治疗和癌症中疾病模型的发现方面取得更快的成功。 2014年6月上旬，国家癌症研究所（NCI）发布了PAR-14-239，将OMF描述为“用于指导生成，验证和证书新模型的信息的综合资源，并为其实际用途提供了信息，推进了建模技术，[并]提供了可用模型资源，程序和服务的目录。”为了最大程度地利用可用资源的使用，该在线网站被规定使用Hubzero，这是一个现有的开源科学网站框架，避免了从头开始昂贵的新科学网站的昂贵创建。 OMF被设计为社区建设工具，其中包括在线讨论论坛和年度会议。特定内容将由与OMF并行资助的协作R01提供。临床前小鼠和室内模型对于癌症的未来翻译至关重要。 2013年发表了4,300多个手稿，描述或使用癌症小鼠模型，包括Xenographic和移植模型，自发模型，近交小鼠以及基因工程的小鼠模型（GEMM）。 NCI癌症模型数据库（Camod）现在列出了数千种容易在一个或多个部位发展肿瘤的小鼠模型。但是这些模型的数据散布在众多资源中。现在，使用癌症鼠标模型在研究中的未来成功却较少依赖于新模型的持续创建，并且更依赖于数千种当前可用模型的验证，对这些模型的知识和数据的透明访问，模型数据与人类数据的比较以及研究社区的组织。我们计划开发肿瘤模型论坛（OMF）来实现这些目标。我们提出的OMF将在癌症鼠标模型上整合结构化和非结构化的数据以及知识，从而实现新的发现以及新的翻译工具的开发。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Widespread parainflammation in human cancer.

DOI：
10.1186/s13059-016-0995-z
发表时间：
2016-07-08
期刊：
Genome biology
影响因子：
12.3
作者：
Aran D;Lasry A;Zinger A;Biton M;Pikarsky E;Hellman A;Butte AJ;Ben-Neriah Y
通讯作者：
Ben-Neriah Y

Future cancer research priorities in the USA: a Lancet Oncology Commission.

DOI：
10.1016/s1470-2045(17)30698-8
发表时间：
2017-11
期刊：
The Lancet. Oncology
影响因子：
0
作者：
Jaffee EM;Dang CV;Agus DB;Alexander BM;Anderson KC;Ashworth A;Barker AD;Bastani R;Bhatia S;Bluestone JA;Brawley O;Butte AJ;Coit DG;Davidson NE;Davis M;DePinho RA;Diasio RB;Draetta G;Frazier AL;Futreal A;Gambhir SS;Ganz PA;Garraway L;Gerson S;Gupta S;Heath J;Hoffman RI;Hudis C;Hughes-Halbert C;Ibrahim R;Jadvar H;Kavanagh B;Kittles R;Le QT;Lippman SM;Mankoff D;Mardis ER;Mayer DK;McMasters K;Meropol NJ;Mitchell B;Naredi P;Ornish D;Pawlik TM;Peppercorn J;Pomper MG;Raghavan D;Ritchie C;Schwarz SW;Sullivan R;Wahl R;Wolchok JD;Wong SL;Yung A
通讯作者：
Yung A

Cancer Cell-Autonomous Parainflammation Mimics Immune Cell Infiltration.