Graduated sensory salience as an intervention for intrusive negative thinking

分级感官显着性作为侵入性消极思维的干预措施

基本信息

批准号：
9888427
负责人：
GREG J SIEGLE
金额：
$ 30.93万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-01 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9888427
关键词：
Acute Affect Anxiety Attention Behavioral Biological Brain Clinical Cognition Cognitive Crying Depressed mood Dimensions Discipline Educational Intervention Electroencephalography Elements Emotional Esthesia Evaluation Feedback Functional Magnetic Resonance Imaging Goals Individual Intervention Lip structure Measures Mental Depression Mental disorders Mind Modernization Moods Outcome Pain Parietal Participant Pathway interactions Patient Self-Report Patients Pharmacology Phase Placebos Positioning Attribute Pruritus Psychometrics Psychopathology Psychotherapy Randomized Controlled Trials Recording of previous events Resistance Rod Sensory Stimulus Suicide Symptoms System Techniques Thinking Training Trauma Treatment outcome Volition Work Yang chronic pain cognitive control cognitive task cognitive training directed attention dysphoria emotion regulation emotional stimulus improved indexing midbrain central gray substance neural circuit neurobehavioral neuroimaging novel post intervention preservation prognostic psychologic recruit relating to nervous system response sensory stimulus somatosensory success sustained attention

项目摘要

DESCRIPTION (provided by applicant): Intrusive negative cognitions are key transdiagnostic features of many psychiatric disorders, are difficult to treat, and predict poor outcomes in conventional and neurobehavioral interventions. Here, we evaluate the extent to which a novel intervention capitalizing on a preserved neurocircuitry for attending to evolutionarily salient somatosensory stimuli can be used to train attentional mechanisms to override otherwise pre-potent negative cognitions. The R21 period will involve intervention refinement and mechanistic evaluation of mechanism; N=35 individuals with high levels of intrusive negative cognitions and dysphoria will be assessed pre/post intervention. The R33 phase will involve mechanistic comparison to control conditions and psychometric evaluation; N=60 individuals with high levels of intrusive negative cognitions and associated dysphoria will undergo either an active intervention involving directed attention to graduated decreasing degrees of physical sensation (N=40) or a non-graduated control condition (N=40). Mechanisms of attentional focus on non-emotional and emotional stimuli will be assessed via neuroimaging in these individuals before and after the intervention along with 20 healthy control participants who will be assessed a twice. Success will suggest a new intervention pathway for a traditionally treatment-resistant dimension of psychopathology.

描述（由适用提供）：侵入性负认知是许多精神疾病的关键转诊特征，难以治疗，并且可以预测常规和神经行为干预措施的不良预后。在这里，我们评估了在保留的神经循环上大写的新干预措施在多大程度上用于参与进化显着的体感刺激，可用于训练注意机制，以覆盖否则预测的负面认知。 R21时期将涉及对机制的干预完善和机械评估； n = 35个患有高水平的侵入性负认知和烦躁不安的人将在干预前/干预后评估。 R33阶段将涉及与控制条件和心理测量评估的机械比较； n = 60个患有高水平的侵入性负认知和相关烦躁不安的人将进行主动干预措施，涉及对渐变的身体感觉降低程度（n = 40）或非授予对照条件（n = 40）的注意力。注意力集中在非情感和情绪刺激上的机制将通过在干预前后的这些个体以及20名健康对照参与者的神经影像来评估，他们将进行两次评估。成功将为传统的心理病理学耐药维度提供新的干预途径。