Research Methods Core

研究方法核心

• 批准号: 8107514
• 负责人: GREG J SIEGLE
• 金额: $ 29.93万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8107514
• 关键词: Affective; Affective Symptoms; Aftercare; Behavior; Brain; Child; Clinical; Cognitive; Cognitive Therapy; Data; Diagnostic; Emotional; Event-Related Potentials; Family; Functional Magnetic Resonance Imaging; Genetic; Home environment; Measurement; Measures; Methodology; Methods; Mydriasis; Outcome Study; Parent-Child Relations; Participant; Patient Self-Report; Process Measure; Protocols documentation; Recovery; Research Methodology; Sleep; Structure; Symptoms; System; Treatment outcome; Youth; actigraphy; base; behavior observation; indexing; information processing; peer; Affective; Affective Symptoms; Aftercare; Behavior; Brain; Child; Clinical; Cognitive; Cognitive Therapy; Data; Diagnostic; Emotional; Event-Related Potentials; Family; Functional Magnetic Resonance Imaging; Genetic; Home environment; Measurement; Measures; Methodology; Methods; Mydriasis; Outcome Study; Parent-Child Relations; Participant; Patient Self-Report; Process Measure; Protocols documentation; Recovery; Research Methodology; Sleep; Structure; Symptoms; System; Treatment outcome; Youth; actigraphy; base; behavior observation; indexing; information processing; peer

Little is known about the mechanisms of change in cognitive behavioral therapy (CBT) for anxious youth, potentially because most treatment outcome studies have focused only on changes in diagnostic status and symptoms, rather than using a multi-method approach to understand changes across multiple systems associated with recovery. Using a transdisciplinary approach, this core will provide an integrated structure for examining changes in symptoms, behavior in family and peer contexts, sleep, and brain reactivity to cognitive and emotional information processing tasks among anxious children before, during, and after CBT and CCT. These data will be used as the basis for analyses across all three of the primary projects. Specifically, this core describes the following assessments. Before and after treatment, participants will complete measures of clinical status, symptoms, affective style, and parent-child interactions using rating scales, self-report measures, and behavioral observations. Genetic data will also be acquired. Participants will complete cognitive and affective information processing measures during fMRI and concurrent pupil dilation/eyetracking assessment, as well as event-related potential (ERP) assessment. On a biweekly basis throughout treatment, participants will complete self-report ratings of symptomatology, pupil dilation/eyetracking assessments, and a home based Ecological Momentary Assessment and sleep actigraphy protocol. This core integrates and oversees the assessment methodologies for all projects. Of particular importance, methods are provided for creating composite summary indices for each primary domain of assessment, for use in each project and in cross-project analyses, via methods developed in Core 3. Having these methods centralized in a single core, with a single project coordinator, and an integrative measurement approach is essential for this CIDAR mechanism. Centralizing the administration of these assessments will 1) contribute to a better understanding of how these assessments fit together, 2) facilitate later integration of analyses and results across projects, and 3) increase efficiency and decrease participant burden by integrating assessments in a convenient and planful manner.

关于焦虑青年的认知行为疗法（CBT）变化的机制知之甚少， 可能是因为大多数治疗结果研究仅集中在诊断状态的变化上 症状，而不是使用多方法方法来了解多个系统的变化 与恢复有关。使用跨学科的方法，该核心将为 检查症状的变化，家庭和同伴环境中的行为，睡眠和大脑对 CBT之前，之中和之后，焦虑的孩子之间的认知和情感信息处理任务 和CCT。这些数据将用作所有三个主要项目分析的基础。 具体而言，该核心描述了以下评估。治疗前后，参与者将 使用评分完成临床状况，症状，情感风格和亲子互动的完整度量 量表，自我报告措施和行为观察。也将获取遗传数据。参与者 将在fMRI和并发学生期间完成认知和情感信息处理措施 扩张/眼影评估以及与事件相关的电位（ERP）评估。每两周 在整个治疗过程中，参与者将完成症状的自我报告评级，学生 扩张/眼影评估以及基于家庭的生态瞬时评估和睡眠 积极的协议。该核心集成并监督所有项目的评估方法。的 特别重要的是，提供了为每位主要的复合摘要索引提供的方法 评估领域，用于每个项目和跨项目分析，通过核心中开发的方法 3。 将这些方法集中在单个核心中，具有单个项目协调器和一个集成 测量方法对于这种CIDAR机制至关重要。集中这些管理 评估将为1）更好地了解这些评估如何结合在一起，2）促进 后来整合项目之间的分析和结果，3）提高效率并降低参与者 通过以方便而计划的方式整合评估来负担。