CBI: Chemistry Biology Interface

CBI：化学生物学接口

• 批准号: 9485969
• 负责人: SUSAN L FORSBURG
• 金额: $ 28.28万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9485969
• 关键词: Biology; Chemistry

 DESCRIPTION (provided by applicant): New opportunities in chemistry and biology are emerging from a convergence of these disciplines to create new, interdisciplinary approaches. The quantitative methods of synthesis, analysis, and mechanism from chemistry merges with a holistic strategy in living systems to synergize the common goal of elucidating fundamental discoveries that impact human health. As biologists increasingly identify new drug targets using genomic and molecular techniques, there is a need for chemists who can design, synthesize, manipulate, and characterize molecules. Their work will be most effective if they are grounded in the fundamental biology of the problem. In addition to providing chemists with in vivo experience, there is also a clear need for molecular biologists to complement their primary expertise with a greater understanding of chemical principles affecting molecular interactions. Training in molecular recognition, design, synthesis, and reactivity, coupled with additional experience in chemical investigative approaches, will expand the range of tools available to students of biological problems. However, chemistry and biology are significantly different cultures, so there is a substantial challenge is to develop young investigators who move comfortably in both disciplines. Many faculty members in the Department of Chemistry and in the Program in Molecular & Computational Biology have a long history of working together in the area of Chemical Biology. This proposal expands that relationship by creating an interdisciplinary, synergistic training program for a subset of PhD students in Chemistry and in Molecular Biology at the interface of these two areas. This is a value-added approach that builds on the depth in each PhD program to create a new training space. The purpose of this proposal is therefore to create a formal pedagogical structure at the chemistry-biology interface that leverages an existing collaborative research environment to provide a distinct experience to a subset of students, generating a cohort with a unique interdisciplinary identity. We anticipate admitting 4 NIH trainees per year for a two year program, leading to a steady state of 8 trainees. This will be a value added program with a distinct training program for our cohort including a unique 2- year seminar course and a research sabbatical. Our goal is to generate a unique cohort with a distinct identity as USC Chemical Biology.

 描述（由适用提供）：化学和生物学方面的新机会已经从这些学科的融合中出现，以创建新的跨学科方法。化学中的合成，分析和机制的定量方法与生命系统中的整体策略合成，以综合阐明影响人类健康的基本发现的共同目标。随着生物学家越来越多地使用基因组和分子技术来识别新药靶标，因此需要化学家可以设计，合成，操纵和表征分子。如果他们基于问题的基本生物学，他们的工作将最有效。除了为化学家提供体内经验外，分子生物学家还显然需要完成其主要专业知识，并对影响分子相互作用的化学原理有更深入的了解。分子识别，设计，合成和反应性的培训，再加上化学研究方法方面的其他经验，将扩大生物学问题学生可用的工具范围。但是，化学和生物学是显着不同的文化，因此存在一个重大挑战，就是要培养在这两个学科中舒适地运动的年轻研究人员。化学系和分子和计算生物学计划的许多教职员工在化学生物学领域共同合作的历史悠久。该建议通过为这两个领域的界面上的化学和分子生物学领域的博士学位学生和分子生物学的一部分，通过创建跨学科的协同培训计划来扩展这种关系。这是一种增值方法，它基于每个博士学位计划的深度，以创建一个新的培训空间。因此，该提案的目的是在化学生物学界面上建立正式的教学结构，该界面利用现有的协作研究环境为一部分学生提供了独特的体验，从而产生了具有独特的跨学科身份的队列。我们预计每年为期两年的计划将入学4名NIH学员，导致8名学员的稳态。这将是一个增值计划，并为我们的队列提供独特的培训计划，包括独特的2年半课程和休假研究。我们的目标是生成具有USC化学生物学独特身份的独特队列。