P20 Exploratory Center for Precision Health in Diverse Populations

P20多元化人群精准健康探索中心

• 批准号: 9760003
• 负责人: GAIL D MELKUS
• 金额: $ 14.36万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9760003
• 关键词: Address; Atmosphere; Award; Basic Behavioral Science; Behavioral; Biological; Biometry; Cardiovascular Diseases; Characteristics; Chronic; Collaborations; Communication; Communities; Country; Data; Development; Diagnosis; Disadvantaged; Discipline of Nursing; Ecology; Effectiveness; Elderly; Ensure; Ethics; Evaluation; Faculty; Fostering; Funding; Gender Identity; Generations; Genomics; Goals; Grant; Grant Review; Health; Human; Hypertension; Infrastructure; Intervention; Lead; Leadership; Learning; Legal; Life Style; Maintenance; Mentors; Metabolic syndrome; Methods; Mission; Nature; Non-Insulin-Dependent Diabetes Mellitus; Nurses; Nursing Research; Outcome; Physiological; Policies; Population Heterogeneity; Precision Health; Principal Investigator; Procedures; Process; Productivity; Public Health; Regulation; Religion; Research; Research Personnel; Research Support; Resources; Risk; School Nursing; Science; Scientist; Self Management; Sex Orientation; Spirituality; Symptoms; Technology; Testing; Time; Vulnerable Populations; Woman; Work; Writing; biobehavior; cardiovascular disorder risk; care outcomes; career; career development; disability; epigenomics; ethnic minority population; experience; health disparity; health equity; improved; intergenerational; metabolic abnormality assessment; minority children; multiple chronic conditions; operation; programs; psychological outcomes; racial and ethnic; racial minority; real world application; skills; success; synergism; transgender; web site

Abstract/Project Summary ADMINISTRATIVE CORE This proposal responds to RFA-NR-10-002: NINR Exploratory Center (P20). The overall goal of our proposed NYU Meyers P20 Exploratory Center for Precision Health in Diverse Populations is to improve health outcomes by addressing biologically diverse and common mechanisms, symptoms, modifiable factors, and non-modifiable factors of metabolic syndrome (MetS) and resulting type 2 diabetes (T2D), cardiovascular disease (CVD), and related multiple chronic conditions (MCC) that occur simultaneously and complicate diagnosis and treatment. We will approach this work from a precision ecological perspective. Some of the most significant barriers to implementation of this work are in determining how best to engage diverse communities in the science and of biobehavioral, omic, contextual, lifestyle and familial factors implicated in MetS and MCC and how best to intervene and reduce risks. We will conduct this research in diverse groups that are historically under-represented in research, including racial/ethnic minorities, children, women, elderly, and other vulnerable populations. Other characteristics such as sexual orientation (LGBQ), gender identity (non-cis or transgender), disability status, religion or spirituality, SES-disadvantaged backgrounds, and country of origin will also be considered in our research. The Center's Administrative Core is focused on supporting research to address these issues in real world applications of a precision ecological approach among diverse populations to improve public health. The Administrative Core will be responsible for coordinating and overseeing the scientific and administrative activities of the Center, including the overall aims, internal and external communications, compliance, evaluation, and sustainability. We will evaluate the productivity, effectiveness, and appropriateness of Center activities; determine criteria for center affiliations, and foster collaborations throughout NYU with researchers studying MetS, T2D, CVD, and related chronic conditions. All activities will align with the Center's overall goal of supporting research on biologically diverse and common mechanisms, symptoms, modifiable factors, and non-modifiable factors that underlie MetS and related MCC, to improve health care outcomes and reduce health disparities.

摘要/项目摘要 行政核心 该提案对RFA-NR-10-002：NINR探索中心（P20）做出回应。我们提议的总体目标 NYU MEYERS P20在不同人群中的精确健康探索中心是为了改善健康状况 通过解决生物学上多样化和共同机制，症状，可修改因素以及 代谢综合征（METS）和由此产生的2型糖尿病（T2D），心血管造成的不可抑制因子 疾病（CVD）以及同时且复杂的相关多个慢性病（MCC） 诊断和治疗。我们将从精确的生态学角度来处理这项工作。其中一些 实施这项工作的重大障碍在于确定如何最好地吸引各种社区 在科学和生物行为，奥马斯，情境，生活方式和家庭因素中与大都会和MCC有关 以及如何最好地干预和降低风险。我们将在历史上的不同群体中进行这项研究 研究不足，包括种族/族裔少数民族，儿童，妇女，老年人和其他 脆弱的人群。其他特征，例如性取向（LGBQ），性别认同（非CIS或 变性者），残疾状况，宗教或灵性，SES偏爱背景和原籍国 我们的研究也将被考虑。该中心的行政核心专注于支持研究 在现实世界中，在不同人群中的精确生态学方法的现实应用中解决了这些问题 改善公共卫生。 行政核心将负责协调和监督科学和行政 该中心的活动，包括整体目标，内部和外部沟通，合规性， 评估和可持续性。我们将评估中心的生产率，有效性和适当性 活动;确定中心隶属关系的标准，并与研究人员培养纽约大学的合作 研究MetS，T2D，CVD和相关的慢性条件。所有活动都将与中心的总体目标保持一致 支持对生物学上多样化和共同机制，症状，可修改因素以及的研究 基于大都会大都会和相关MCC的不可修改因素，以改善医疗保健结果并减少 健康差异。