P20 Exploratory Center for Precision Health in Diverse Populations

P20多元化人群精准健康探索中心

基本信息

批准号：
10175054
负责人：
GAIL D MELKUS
金额：
$ 37.54万
依托单位：
NEW YORK UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-08 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10175054
关键词：
Address Adult Advisory Committees Biodiversity Biological Biological Markers Biology Body mass index Carbohydrates Cardiovascular Diseases Care given by nurses Caring Centers for Disease Control and Prevention (U.S.)Chronic Chronic Disease Clinical Practice Guideline Communities Development Diet Direct Costs Disadvantaged Discipline of Nursing Disease Dyslipidemias Ecology Education Elderly Environment Environmental Exposure Environmental Impact Environmental Risk Factor Epigenetic Process Faculty Family Family history of Fatigue Foundations Funding Future Genetic Genetic Predisposition to Disease Genomics Goals Health Hypertension Individual Infrastructure Insulin Resistance Intervention Knowledge Life Style Mentors Metabolic syndrome Modeling Morbidity - disease rate Non-Insulin-Dependent Diabetes Mellitus Nurses Nursing Research Obesity Outcome Pain Patient Care Persons Phenotype Physical activity Pilot Projects Plant Roots Play Population Population Heterogeneity Precision Health Prevention Preventive care Recording of previous events Research Research Infrastructure Research Personnel Research Support Resources Review Committee Risk Risk Factors Risk Management Role Science Scientist Sleep Socioeconomic Status Strategic Planning Sustainable Development Symptoms Technology United States National Institutes of Health Vulnerable Populations Woman biobehavior cardiovascular disorder risk career cigarette smoking college common symptom emotional distress health disparity health inequalities improved individual variation innovation lifestyle factors modifiable risk mortality multiple chronic conditions palliative peer persistent symptom person centered personalized care personalized strategies premature prevent programs racial and ethnic saturated fat sedentary lifestyle substance use sugar symptom cluster symptom management symptom science

项目摘要

Project Summary/Abstract The NYU Meyers College of Nursing is uniquely poised to propose a P20 Exploratory Center for Precision Health in Diverse Populations to promote nursing research in metabolic syndrome (MetS) and related multiple chronic conditions (MCC). Guided by a precision health ecological framework, this center aims to (1) promote innovative research on the complexity, relatedness, biodiversity, and impact on individuals and families of MetS and MCC using a precision health ecological perspective, including biomarkers (genetics/genomics), ancestry, community, and environmental factors and the NINR CDE; (2) develop and sustain a research infrastructure to support and accelerate early career scientists in exploring MetS and MCC in diverse individuals and families from a precision health ecological perspective; and (3) facilitate the development of sustainable interdisciplinary collaborative teams dedicated to advancing the science of MCC by obtaining external funding and conducting impactful research. Metabolic syndrome (MetS) is a set of inter-related health conditions placing individuals at serious risk for T2D and CVD. MetS is a prodromal state that sets the stage for CVD and T2D. Hypertension, dyslipidemia, insulin resistance, and obesity are common factors that comprise MetS. MetS is present in ~ 35% of adults in the US. A family history of MCC that includes type 2 diabetes (T2D), hypertension, and early cardiovascular disease (CVD) greatly increases the chance that an individual will develop MetS. Genetics and environment play a role in chronic conditions; this is particularly true of MetS. Other causes of MetS and associated T2D and CVD risk include genetic susceptibility, family history, low education and socioeconomic status, increased body mass index (BMI), and lifestyle factors, especially sedentary lifestyle/lack of regular physical activity; diet high in refined carbohydrates, sugar, and saturated fat; cigarette smoking; and substance use 1-6. Research that expands our understanding of biomarkers, lifestyle, contextual, and environmental impacts on phenotypic expression of MetS and related MCC among diverse, vulnerable populations is lacking and critically needed. The infrastructure will include 3 Cores-Administrative Core guided by an Executive Committee and an External Advisory Committee; Pilot Administrative Core with Pilot Feasibility Funding and a Scientific Review Committee; Precision Technology Resource Core, and an Enrichment Program. Two pilot projects will address symptom clusters and biomarkers of MetS related to sleep duration and fatigue. The NYU Meyers College of Nursing has faculty investigators and research scientists with programs of biobehavioral research, funded by NIH, CDC, NSF, and foundations ($9.3 million in direct costs), that address risk, management, and intervention for MCC. These researchers will serve as mentors, collaborators, and resources for the Center pilot PIs and their collaborators. The Center will allow for more individualized care and extend nursing science by offering biomarker, genetic/genomic, biobehavioral, lifestyle, and environmental explanations that will inform nursing care for diverse populations with symptoms of MetS.

项目摘要/摘要纽约大学迈尔斯护理学院（Nyu Meyers College of Nursing）唯一准备为P20探索中心提出精确的P20 各种人群的健康以促进代谢综合征（METS）的护理研究和相关多重慢性病（MCC）。在精确的健康生态框架的指导下，该中心旨在（1）促进关于复杂性，相关性，生物多样性以及对个人和家庭影响的创新研究 Mets和MCC使用精确的健康生态学观点，包括生物标志物（遗传学/基因组学），祖先，社区和环境因素以及NINR CDE；（2）发展和维持研究支持和加速早期职业科学家的基础设施，以探索大都会和MCC 从精确的健康生态学角度来个人和家庭；（3）促进可持续的跨学科合作团队，致力于通过获得MCC科学的科学外部资金和进行有影响力的研究。代谢综合征（METS）是一组相互关联的健康使个人面临T2D和CVD的严重风险的条件。大都会是一个前瞻性状态，它设置了舞台对于CVD和T2D。高血压，血脂异常，胰岛素抵抗和肥胖是常见因素包括大都会。大都会在美国的成年人中有约35％。包括2型的MCC家族史糖尿病（T2D），高血压和早期心血管疾病（CVD）极大地增加了机会个人将发展大都会。遗传学和环境在慢性疾病中起作用；这尤其正确大都会。 Mets以及相关T2D和CVD风险的其他原因包括遗传敏感性，家族史，低教育和社会经济地位，体重指数增加（BMI）和生活方式因素，尤其是久坐的生活方式/缺乏常规体育锻炼；饮食中高的精制碳水化合物，糖和饱和脂肪；吸烟；和物质使用1-6。扩展我们对生物标志物，生活方式的理解，情境和环境对MetS和相关MCC表型表达的影响，不同，缺乏脆弱的人口和迫切需要。基础设施将包括3个核心管理由执行委员会和外部咨询委员会指导的核心；飞行员行政核心与飞行员可行性资金和科学审查委员会；精密技术资源核心，丰富计划。两个试点项目将解决与睡眠有关的大都会大会的症状簇和生物标志持续时间和疲劳。纽约大学迈尔斯护理学院拥有教职员工和研究科学家由NIH，CDC，NSF和基金会资助的生物行为研究计划（直接成本为930万美元），该解决MCC的风险，管理和干预。这些研究人员将担任导师，合作者和中心飞行员PIS及其合作者的资源。该中心将允许更多通过提供生物标志物，遗传/基因组，生物行为，生活方式，以及环境解释，这些解释将为各种人群的护理提供信息，并出现大都会的症状。