2019 Multi-Drug Efflux Systems GRC/GRS

2019 多药物外排系统 GRC/GRS

• 批准号: 9760371
• 负责人: Deanna L Kroetz
• 金额: $ 0.75万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-06 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9760371
• 关键词: Academia; Address; Affect; Basic Science; Biochemical; Biological Assay; Biology; Biophysics; Biotechnology; Career Choice; Chemicals; Climate; Clinical; Clinical Pharmacology; Collaborations; Communicable Diseases; Computer Analysis; Cryoelectron Microscopy; Data; Development; Discipline; Drug Efflux; Drug Kinetics; Drug Targeting; Drug resistance; Ensure; Environment; Fostering; Future; Genomics; Goals; Grant; Health; Hour; Human; Industry; Infection; Infectious Agent; International; Intervention; Italy; Knowledge; Learning; Lung diseases; Malaria; Malignant Neoplasms; Medicine; Mentorship; Methods; Microbiology; Minority; Modernization; Molecular; Multi-Drug Resistance; Nature; Oral; Participant; Pharmacodynamics; Pharmacologic Substance; Pharmacology; Pharmacotherapy; Postdoctoral Fellow; Property; Pump; Request for Proposals; Research; Research Personnel; Resistance; Science; Scientific Advances and Accomplishments; Scientist; Senior Scientist; Signaling Molecule; System; Time; Toxic effect; Translating; Translational Research; Tuberculosis; Underrepresented Minority; Woman; Writing; career; collaborative environment; design; diarrheal disease; drug discovery; drug resistant pathogen; efflux pump; global health; graduate student; improved; inhibitor/antagonist; innovation; membrane reconstitution; metabolomics; microorganism; new therapeutic target; novel; novel strategies; novel therapeutic intervention; organ on a chip; peer; posters; prevent; small molecule therapeutics; success; supportive environment; symposium; systems research; therapeutic development; tool; unpublished works

Project Summary The modern era of discovery and clinical use of small molecule therapeutics to treat infectious diseases is threatened by rapidly spreading drug resistance. Drug resistance affects all major groups of infectious diseases but is particularly troubling among causative agents of such devastating infections as diarrheal and respiratory diseases, malaria and tuberculosis. Concerted efforts among basic, translational and drug discovery researchers are urgently needed to prevent further spread of resistance and to develop effective approaches to anticipate and to counter present and future drug resistant pathogens. This proposal requests partial support for the Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Multidrug Efflux Systems to be held in Barga, Italy, April 27-May 3, 2019. This conference will fill a major gap in addressing critical issues and novel approaches to achieve the goals of effective reversal of persistent multidrug resistance worldwide and the development of therapeutics with optimal efficacy and reduced toxicity. The goal of this conference and seminar is to provide a stimulating and collaborative environment for researchers to openly discuss unpublished work, push the boundaries of science, and foster scientific interactions between young investigators, leaders in the field, and colleagues working in academia and the pharmaceutical/biotechnology industry. A major goal is to bring together researchers with expertise in diverse disciplines who traditionally have limited interaction to share progress and engage in discussion of challenges and opportunities in the field. The participation of researchers studying multidrug resistance pumps in microorganisms and those studying mammalian efflux pumps is designed to introduce technological advances and transformative approaches to each field. The goals of this GRC will be accomplished by the internationally recognized keynote speakers, the eight scientific sessions with over 30 invited speakers and additional discussion leaders, and the unique format and setting that facilitates fruitful interactions between participants at all career stages. Speakers in each session will present cutting-edge, unpublished data and innovative ideas on issues that are critical to the success of targeting multidrug efflux pumps for the reversal of resistance. The interactive nature of the GRC scientific and poster sessions and the participation of researchers from diverse research sectors is an optimal forum for graduate students and postdoctoral fellows to expand their scientific breadth, interact with leaders in the field, establish future collaborative relationships and consider various career paths. Submitted abstracts from trainees and underrepresented minorities will be targeted for oral presentations in each session. Through participation in the GRS prior to the main conference, trainees will have additional opportunities for oral and poster presentations and to develop relationships with their peers in a nurturing environment. The 2019 GRC and GRS on Multidrug Efflux Systems will further stimulate cutting-edge basic and translational research on the important biomedical problem of multidrug resistance.

项目概要 发现和临床使用小分子疗法治疗传染病的现代时代是 受到迅速蔓延的耐药性的威胁。耐药性影响所有主要传染群体 疾病，但在腹泻和腹泻等毁灭性感染的病原体中尤其令人不安。 呼吸道疾病、疟疾和结核病。基础、转化和药物的共同努力 迫切需要发现研究人员来防止耐药性进一步蔓延并开发有效的 预测和对抗当前和未来耐药病原体的方法。本提案要求 部分支持戈登研究会议（GRC）和戈登研究研讨会（GRS） Multidrug Efflux Systems 将于 2019 年 4 月 27 日至 5 月 3 日在意大利巴尔加举行。本次会议将填补 解决关键问题和新方法，以实现有效扭转持续存在的目标 世界范围内的多重耐药性以及具有最佳疗效和降低毒性的治疗方法的开发。 本次会议和研讨会的目标是提供一个激励和协作的环境 研究人员公开讨论未发表的工作，突破科学的界限，促进科学发展 年轻研究者、该领域的领导者以及学术界和学术界的同事之间的互动 制药/生​​物技术行业。一个主要目标是将具有不同领域专业知识的研究人员聚集在一起 传统上互动有限、无法分享进展并参与挑战讨论的学科 以及该领域的机会。多药耐药泵研究人员的参与 微生物和哺乳动物外排泵的研究旨在引入技术进步 以及每个领域的变革方法。本次 GRC 的目标将由国际组织来实现 得到认可的主讲人、八场科学会议以及超过 30 名受邀演讲者和其他 讨论的领导者，以及促进参与者之间富有成效的互动的独特形式和环境 所有职业阶段。每场演讲嘉宾将介绍前沿、未发表的数据和创新想法 关于针对多药物外排泵成功逆转耐药性至关重要的问题。这 GRC 科学和海报会议的互动性以及来自不同领域的研究人员的参与 研究部门是研究生和博士后拓展其科学领域的最佳论坛 广度，与该领域的领导者互动，建立未来的合作关系并考虑各种 职业道路。受训者和代表性不足的少数群体提交的摘要将用于口头 每场会议的演讲。通过在主会议之前参加 GRS，学员将 有额外的机会进行口头和海报展示，并与同行发展关系 培育环境。 2019年多药外排系统GRC和GRS将进一步激发尖端技术 多重耐药这一重要生物医学问题的基础和转化研究。