ADMINISTRATIVE SUPPLEMENT TO GRANT R01-AG057424, Short-term Measurements of Physical Resilience as a Predictor of Healthspan in Mice.

授予 R01-AG057424 的行政补充，短期身体弹性测量作为小鼠健康寿命的预测因子。

• 批准号: 9752040
• 负责人: ARLAN G. RICHARDSON
• 金额: $ 10.97万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9752040
• 关键词: Acarbose; Administrative Supplement; Aging; Animals; Development; Estradiol; Funding; Health Status; Lesion; Measurement; Measures; Mus; Pathologic; Pathologist; Pathology; Research; Stress; Testing; Wages; dietary restriction; experimental study; healthspan; intervention effect; novel; parent grant; resilience

This administrative supplement application represents a new opportunity that has arisen from the recent development of the Geropathology Grading Platform (GGP) by the NIA funded Geropathology Research Network. This novel assessment of mouse pathology was only fully developed after the parent grant was submitted. Funds are requested to support the salary of Dr. Breshears, a veterinary pathologist, who will use the recently developed GGP to assess health status of the animals that will be tested in Aims 2 and 3 for their resilience to stress. The supplement requested here will allow us to use the newly developed GGP to measure global pathology in the same mice that we will use to measure resilience to stress. After the mice have been tested for resilience, they will be terminated, and the global pathological status of each animal will be assessed by the GGP. Because the occurrence of pathological lesions is a hallmark of aging, the global pathological status of the mice gives us a measure of healthspan. Thus, we will be able to determine how well our measures of resilience predict the healthspan of the mice we are studying. In addition, these experiments will be the first to use the GGP to assess the effect of interventions such as dietary restriction, acarbose, and 17-α-estradiol on global pathology.

此次行政补充申请代表了一个新的机遇 NIA 资助的老年病理学最近开发了老年病理学分级平台 (GGP) 研究网络。这种对小鼠病理学的新颖评估是在父母之后才完全开发出来的。 已提交补助金以支持兽医 Breshears 博士的工资。 病理学家将使用最近开发的 GGP 来评估将要接受治疗的动物的健康状况 在目标 2 和 3 中测试了它们的抗压能力。此处要求的补充将允许我们使用。 新开发的 GGP 用于测量我们将用来测量的同一只小鼠的整体病理学 小鼠的应激能力测试完成后，它们将被处决，并进行全球性的评估。 每只动物的病理状态都会由GGP进行评估，因为病理的发生。 病变是衰老的标志，小鼠的整体病理状态为我们提供了健康寿命的衡量标准。 因此，我们将能够确定我们的恢复力测量对小鼠健康寿命的预测效果 此外，我们正在研究，这些实验将首次使用GGP来评估效果。 饮食限制、阿卡波糖和 17-α-雌二醇等干预措施对全球病理学的影响。