Coronary Fractional Flow Reserve Determined Using MRI and CFD

使用 MRI 和 CFD 确定冠状动脉血流储备分数

基本信息

批准号：
9887194
负责人：
JOHN N OSHINSKI
金额：
$ 35.47万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2025-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9887194
关键词：
Anatomy Angiography Angioplasty Arteries Blood Vessels Blood flow Cardiac Cardiology Catheterization Cause of Death Clinical Clinical Trials Collaborations Complex Computing Methodologies Coronary Coronary Arteriosclerosis Coronary Stenosis Coronary artery Development Diagnostic Distal Environment Equation Etiology Event Geometry Goals Guidelines Heart Diseases Image Imaging Techniques Imaging technology In Vitro Individual Industry Intervention Ionizing radiation Joints Knowledge Laboratories Lesion Liquid substance Magnetic Resonance Imaging Mathematics Measurement Measures Medical Imaging Methodology Methods Modeling Motion Multi-Institutional Clinical Trial Non-Invasive Lesion Outcome Patient Selection Patient-Focused Outcomes Patients Physiological Procedures Protocols documentation Radiology Specialty Resources Rest Roentgen Rays Severities Stenosis Stents Stress Study models Technology Testing Time United States Universities base bioimaging clinical implementation computational pipelines computer science coronary lesion experimental study image processing imaging modality improved in vivo novel percutaneous coronary intervention pressure reconstruction simulation tool

项目摘要

Project Summary The primary interventional treatment for ischemic coronary artery disease (CAD) is percutaneous intervention (PCI) involving angioplasty and deployment of a vascular stent. Clinical trials have shown that fractional flow reserve (FFR), which is assessed by taking the ratio of pressure distal to the stenosis divided by pressure proximal to the stenosis, reduces the number of adverse cardiac events compared to the use of angiographic-based anatomical criteria alone. Despite its benefit, invasive measurement of FFR is not widely used due to its high expense and procedural complexity. Magnetic resonance imaging (MRI) combined with computational fluid dynamics (CFD) offers a method for determining FFR non-invasively and without ionizing radiation. MRI can be used for coronary artery imaging, can measure coronary flow, is non-invasive, and does not use ionizing radiation. Therefore, our first objective is to develop, validate, and test a cardiac MRI-based method to determine coronary FFR (FFRMRI). We will team with the Siemens Healthineers MRI collaboration division to develop and test new image acquisition and reconstruction methodology, and team with the Siemens Healthineers Medical Imaging Technology division to develop image processing methods and display technology. The new paradigm will be tested in healthy controls and in models studies, then applied to a group of subjects with stable CAD.

项目摘要缺血性冠状动脉疾病（CAD）的主要介入治疗是经皮的干预（PCI）涉及血管成形术和血管支架部署。临床试验表明分数流量储备（FFR），通过将压力远端与狭窄的压力划分为与使用相比，狭窄近端的压力减少仅基于血管造影的解剖标准。尽管受益，但FFR的侵入性测量并不广泛由于其高费用和程序上的复杂性而使用。磁共振成像（MRI）与计算流体动力学（CFD）相结合提供了一种方法用于非侵入性和无电离辐射的确定。 MRI可用于冠状动脉成像，可以测量冠状动脉流量，无创，并且不使用电离辐射。因此，我们的第一个目标是开发，验证和测试一种基于心脏MRI的方法来确定冠状动脉FFR（FFRMRI）。我们将团队与西门子卫生师MRI合作部一起开发和测试新的图像获取和重建方法，并与西门子卫生师医学成像技术部队团队合作开发图像处理方法和显示技术。新范式将在健康对照中进行测试在模型研究中，然后应用于具有稳定CAD的一组受试者。