CRT Lead Placement Planning using MRI

使用 MRI 进行 CRT 导线放置规划

• 批准号: 8442235
• 负责人: JOHN N OSHINSKI
• 金额: $ 16.97万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8442235
• 关键词: Address; Anatomy; Area; Cardiac; Cicatrix; Computer software; Contracts; Controlled Clinical Trials; Coronary; Data; Development; Devices; Evaluation; Evaluation Methodology; Goals; Heart failure; Image; Implant; International; Lead; Left; Location; Magnetic Resonance Imaging; Maps; Mechanics; Methodology; Methods; Myocardial; Myocardium; Outcome; Pacemakers; Patient Selection; Patients; Performance; Pharmaceutical Preparations; Physiological; Placebo Control; Positioning Attribute; Procedures; Prospective Studies; Refractory; Retrospective Studies; Risk; Role; Selection Criteria; Series; Software Validation; Structure of left gastric vein; Techniques; Testing; Time; Tissues; Venous; Ventricular; Work; base; candidate selection; clinical practice; implantation; improved; research clinical testing; response; software development; success; tool

DESCRIPTION (provided by applicant): Cardiac resynchronization therapy (CRT) using a bi-ventricular pacemaker is an important treatment option for patients with drug-refractory heart failure and evidence of ventricular dyssynchrony. However, using current selection criteria and implantation techniques, 30-40% of patients undergoing CRT are non-responsive to the treatment. Because CRT is invasive, costly, has significant associated risks, and requires lifelong need of pacing device, there is a clear need for better methods to optimize the treatment. Multiple factors influence patient response to CRT including poor selection criteria and/or non-optimal device implementation. In the implementation of CRT, the position of the left ventricular (LV) pacing lead has a significant role in determining patient response. The overall goals of this project are: 1) to develop an MRI- based methodology to plan and locate the LV pacing lead in the area of latest contraction and 2) test the methodology on a group of patients undergoing CRT.

描述（由申请人提供）：使用双室性起搏器的心脏重新同步疗法（CRT）对于患有药物难治性心力衰竭和室性室性障碍的证据的患者是重要的治疗选择。但是，使用当前的选择标准和植入技术，30-40％接受CRT的患者对治疗无反应。由于CRT具有侵入性，代价高昂，具有显着的相关风险，并且需要终生对起搏装置的需求，因此显然需要更好的方法来优化治疗方法。多个因素影响患者对CRT的反应，包括较差的选择标准和/或非最佳设备实施。在实施CRT时，左心室（LV）起搏铅的位置在确定患者反应方面具有重要作用。该项目的总体目标是：1）开发一种基于MRI的方法，以计划和定位最新收缩领域的LV起搏铅； 2）对正在接受CRT的一组患者进行测试方法。

项目成果

Performance of 3D, navigator echo-gated, contrast-enhanced, magnetic resonance coronary vein imaging in patients undergoing CRT.

• DOI: 10.1007/s10840-014-9934-7
• 发表时间: 2014-11
• 期刊: JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
• 影响因子: 1.8
• 作者: Lam, Adrian;Mora-Vieira, Luis F.;Hoskins, Michael;Lloyd, Michael;Oshinski, John N.
• 通讯作者: Oshinski, John N.

Combined Angiography and Late Gadolinium Enhancement Acquisition to Improve Assessment of Pulmonary Vein Isolation for Atrial Fibrillation.

• DOI: 10.1002/jmri.25771
• 发表时间: 2018-03
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Lam A;Okene E;Parikh A;Zhong X;Tejada T;Hoskins M;Lloyd M;Oshinski JN
• 通讯作者: Oshinski JN