Healthy transitions from mid-life to early older age: biomedical follow-up of 1958 Birth Cohort Study members at age 60

从中年到老年的健康过渡：1958 年出生队列研究成员 60 岁时的生物医学随访

• 批准号: 9756127
• 负责人: David Batty
• 金额: $ 32.33万
• 依托单位: UNIVERSITY COLLEGE LONDON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9756127
• 关键词: Achievement; Adult; Affect; Age; Age-Years; Aging; Anthropometry; Anxiety; Applications Grants; Area; Behavioral; Biological; Biological Aging; Birth; Blood Pressure; Body fat; British; C-reactive protein; Cardiovascular Diseases; Caring; Cellular Phone; Characteristics; Child Development; Childhood; Chronic Disease; Cognition; Cohort Studies; Collection; Communities; Country; Data; Data Collection; Deposition; Development; Economics; Educational Intervention; Elderly; Elements; Equilibrium; Exercise; Fibrinogen; Frequencies; Funding; Future; Gait speed; Generations; Genes; Genotype; Glycosylated hemoglobin A; Gold; Hand Strength; Health; Height; High Density Lipoprotein Cholesterol; Hip region structure; Home visitation; Human; Impaired cognition; Interview; Interviewer; Investments; Life; Life Cycle Stages; Life Expectancy; Maintenance; Malaise; Malignant Neoplasms; Measures; Medical Research; Medicine; Mental Depression; Mental Health; Metabolic Diseases; Non-Insulin-Dependent Diabetes Mellitus; Nurses; Older Population; Outcome; Participant; Personal Satisfaction; Phenotype; Physical Function; Policies; Population; Process; Public Health; Pulse Rates; Questionnaire Designs; Randomized; Research; Research Personnel; Research Priority; Resources; Running; Sampling; Sampling Studies; Scientist; Series; Smoke; Surveys; United States National Institutes of Health; Weight; Whole Blood; Work; aging population; bone; cardiovascular disorder risk; cognitive function; cognitive training; cohort; data archive; design; early life exposure; executive function; follow-up; frailty; healthy aging; improved; innovation; insight; instrument; life history; member; memory process; middle age; modifiable behavior; policy implication; processing speed; prospective; psychologic; psychological distress; social; socioeconomics

7. Project Summary/Abstract The unrivalled increase in human life expectancy over the last century has been one of the greatest achievements of public health medicine. However, it also poses new and unique challenges in health and social care, in particular the increased burden of chronic diseases and associated ageing states, including cognitive impairment and frailty. Understanding the occurrence and determinants of these ageing outcomes has become a global research priority with considerable policy implications. Several studies have been established in middle- and older-aged populations in the US (HRS, MIDUS) with the capacity to offer much- needed insights into these issues. However, it has recently become evident that the processes that underlie ageing states begin much sooner in the life course than originally thought, in some cases as early as birth or preconception. It is in such life course-orientated studies that the USA is surprisingly bereft. The 1958 British Birth Cohort Study in the UK is the largest long-running study of this genre. With the study members approaching 60 years of age, when problems of ageing begin to emerge with frequency, we will carry out a detailed phenotypic and genotypic survey which covers an array of areas including biological, psychological, socioeconomic and behavioural characteristics. Uniquely, these new data will allow us to answer a series of important research questions of public health importance, ranging from identifying the policy-modifiable behaviours and biological mechanisms in mid-life that successfully reverse the effects of earlier life exposures and adversities on ageing outcomes, through to examining the long term influence of early life educational interventions on social, health, and ageing outcomes in older age, on to running a series of cross-country, and cross-cohort comparisons, to enable us to highlight where such processes are changing across generations, or between countries. These data will become publically available to bone fide population scientists soon after collection, so providing an unrivalled resource for the scientific community to investigate a range of policy- relevant issues.

7。项目摘要/摘要 上个世纪人类预期寿命无关的增长一直是最伟大的人之一 取得公共卫生医学的成就。但是，它还在健康方面构成了新的和独特的挑战 社会护理，特别是慢性疾病和相关衰老状态的负担增加，包括 认知障碍和脆弱。了解这些衰老结果的发生和决定因素 已经成为具有相当大的政策含义的全球研究优先事项。一些研究已经 在美国（HRS，MIDUS）的中年和老年人口中建立，有能力 需要深入了解这些问题。但是，最近显而易见的是，基于的过程 衰老状态在生活过程中比最初想象的要早得多，在某些情况下， 偏见。正是在这样的生活课程的研究中，美国出人意料地丧失了。 1958年的英国人 英国的出生队列研究是该类型的最大长期研究。与学习成员 接近60岁的年龄，当衰老问题开始出现频率时，我们将执行 详细的表型和基因型调查涵盖了一系列领域，包括生物学，心理学， 社会经济和行为特征。这些新数据独特地将使我们回答一系列 关于公共卫生重要性的重要研究问题，范围从识别政策修改 中期的行为和生物机制成功扭转了早期生活的影响 以及对衰老结果的逆境，以研究早期生活教育的长期影响 对年龄较大的社会，健康和衰老成果的干预，以进行一系列越野和 跨局部比较，使我们能够强调各个一代或 在国家之间。这些数据将在不久之后公开向骨头人口科学家公开使用 收集，因此为科学界提供了无与伦比的资源，以调查一系列政策 - 相关问题。