Healthy transitions from mid-life to early older age: biomedical follow-up of 1958 Birth Cohort Study members at age 60

从中年到老年的健康过渡：1958 年出生队列研究成员 60 岁时的生物医学随访

• 批准号: 9234605
• 负责人: David Batty
• 金额: $ 32.44万
• 依托单位: UNIVERSITY COLLEGE LONDON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9234605
• 关键词: Achievement; Adult; Affect; Age; Age-Years; Aging; Anthropometry; Anxiety; Applications Grants; Area; Behavior; Behavioral; Biological; Biological Aging; Birth; Blood Pressure; Body fat; British; C-reactive protein; Cardiovascular Diseases; Caring; Cellular Phone; Characteristics; Child Development; Childhood; Chronic Disease; Cognition; Cohort Studies; Collection; Communities; Country; Data; Data Collection; Deposition; Development; Economics; Educational Intervention; Elderly; Elements; Equilibrium; Exercise; Fibrinogen; Frequencies; Funding; Future; Gait speed; Generations; Genes; Genotype; Glycosylated hemoglobin A; Gold; Hand Strength; Health; Height; High Density Lipoprotein Cholesterol; Hip region structure; Home visitation; Human; Impaired cognition; Interview; Interviewer; Investments; Life; Life Cycle Stages; Life Expectancy; Maintenance; Malaise; Malignant Neoplasms; Measures; Medical Research; Medicine; Mental Depression; Mental Health; Metabolic Diseases; Non-Insulin-Dependent Diabetes Mellitus; Nurses; Older Population; Outcome; Participant; Phenotype; Physical Function; Policies; Population; Process; Public Health; Pulse Rates; Questionnaire Designs; Randomized; Research; Research Personnel; Research Priority; Resources; Running; Sampling; Sampling Studies; Scientist; Series; Smoke; Surveys; United States National Institutes of Health; Weight; Whole Blood; Work; aging population; bone; cardiovascular disorder risk; cognitive function; cognitive training; cohort; data archive; design; early life exposure; executive function; follow-up; frailty; healthy aging; improved; innovation; insight; instrument; life history; member; memory process; middle age; policy implication; processing speed; prospective; psychologic; psychological distress; social; socioeconomics

7. Project Summary/Abstract The unrivalled increase in human life expectancy over the last century has been one of the greatest achievements of public health medicine. However, it also poses new and unique challenges in health and social care, in particular the increased burden of chronic diseases and associated ageing states, including cognitive impairment and frailty. Understanding the occurrence and determinants of these ageing outcomes has become a global research priority with considerable policy implications. Several studies have been established in middle- and older-aged populations in the US (HRS, MIDUS) with the capacity to offer much- needed insights into these issues. However, it has recently become evident that the processes that underlie ageing states begin much sooner in the life course than originally thought, in some cases as early as birth or preconception. It is in such life course-orientated studies that the USA is surprisingly bereft. The 1958 British Birth Cohort Study in the UK is the largest long-running study of this genre. With the study members approaching 60 years of age, when problems of ageing begin to emerge with frequency, we will carry out a detailed phenotypic and genotypic survey which covers an array of areas including biological, psychological, socioeconomic and behavioural characteristics. Uniquely, these new data will allow us to answer a series of important research questions of public health importance, ranging from identifying the policy-modifiable behaviours and biological mechanisms in mid-life that successfully reverse the effects of earlier life exposures and adversities on ageing outcomes, through to examining the long term influence of early life educational interventions on social, health, and ageing outcomes in older age, on to running a series of cross-country, and cross-cohort comparisons, to enable us to highlight where such processes are changing across generations, or between countries. These data will become publically available to bone fide population scientists soon after collection, so providing an unrivalled resource for the scientific community to investigate a range of policy- relevant issues.

7. 项目总结/摘要 上个世纪人类预期寿命的空前增长是最伟大的增长之一 公共卫生医学成就。然而，它也给健康和健康方面带来了新的、独特的挑战。 社会关怀，特别是慢性疾病和相关老龄化负担的增加，包括 认知障碍和虚弱。了解这些衰老结果的发生和决定因素 已成为具有重大政策影响的全球研究重点。多项研究已 在美国的中老年人群中建立（HRS、MIDUS），有能力提供更多- 需要深入了解这些问题。然而，最近已经变得明显的是，其背后的过程 衰老状态在生命历程中开始的时间比最初想象的要早得多，在某些情况下早在出生或 偏见。正是在这种以生命历程为导向的研究中，美国令人惊讶地缺失了。 1958年的英国人 英国的出生队列研究是该类型最大的长期研究。与学习成员们 临近60岁，当衰老问题开始频繁出现时，我们将进行 详细的表型和基因型调查，涵盖生物学、心理、 社会经济和行为特征。独特的是，这些新数据将使我们能够回答一系列问题 具有公共卫生重要性的重要研究问题，包括确定可修改的政策 成功扭转早年暴露影响的中年行为和生物机制 以及逆境对衰老结果的影响，通过检查早期生活教育的长期影响 对老年人的社会、健康和老龄化结果进行干预，进行一系列越野跑，以及 跨队列比较，使我们能够突出这些过程在代际之间发生的变化，或者 国家之间。这些数据将很快向真正的人口科学家公开 收集，从而为科学界提供无与伦比的资源来调查一系列政策- 相关问题。