Structure-Function Relationship of Glycosaminoglycans

糖胺聚糖的结构-功能关系

• 批准号: 9754832
• 负责人: RAM SASISEKHARAN
• 金额: $ 39万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9754832
• 关键词: Address; Biological Process; Disasters; Glycobiology; Glycosaminoglycans; Heparin; Instruction; Laboratories; Polysaccharides; Proteins; Public Health; Structure-Activity Relationship; tool

The Sasisekharan laboratory focuses on developing tools to study glycan-protein interactions. The laboratory has focused on using these tools to not only instigate the fundamentals of glycans in terms of how they impact biological processes, but they have also harnessed the mechanisms to address important public health crises including the contamination of heparin disaster. The tools developed have implications beyond glycobiology. RELEVANCE (See instructions):

Sasisekharan 实验室专注于开发研究聚糖-蛋白质相互作用的工具。实验室 重点关注使用这些工具，不仅要了解聚糖的基本原理，还要了解它们如何 影响生物过程，但他们也利用机制来解决重要的公众问题 健康危机包括肝素污染灾难。开发的工具的影响超出 糖生物学。 相关性（参见说明）：

项目成果

Antibody-Based Strategies to Prevent and Treat Influenza.

• DOI: 10.3389/fimmu.2015.00315
• 发表时间: 2015
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Shriver Z;Trevejo JM;Sasisekharan R
• 通讯作者: Sasisekharan R

An inter-residue network model to identify mutational-constrained regions on the Ebola coat glycoprotein.

• DOI: 10.1038/srep45886
• 发表时间: 2017-04-11
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Quinlan DS;Raman R;Tharakaraman K;Subramanian V;Del Hierro G;Sasisekharan R
• 通讯作者: Sasisekharan R

Glycan-protein interactions in viral pathogenesis.

• DOI: 10.1016/j.sbi.2016.10.003
• 发表时间: 2016-10
• 期刊: Current opinion in structural biology
• 影响因子: 6.8
• 作者: Raman R;Tharakaraman K;Sasisekharan V;Sasisekharan R
• 通讯作者: Sasisekharan R

Conserved topology of virus glycoepitopes presents novel targets for repurposing HIV antibody 2G12.

• DOI: 10.1038/s41598-022-06157-z
• 发表时间: 2022-02-16
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Miller NL;Subramanian V;Clark T;Raman R;Sasisekharan R
• 通讯作者: Sasisekharan R

Modular glycosphere assays for high-throughput functional characterization of influenza viruses.

用于流感病毒高通量功能表征的模块化糖球测定。

• DOI: 10.1186/1472-6750-13-34
• 发表时间: 2013
• 期刊: BMC biotechnology
• 影响因子: 3.5
• 作者: Hobbie,SvenN;Viswanathan,Karthik;Bachelet,Ido;Aich,Udayanath;Shriver,Zachary;Subramanian,Vidya;Raman,Rahul;Sasisekharan,Ram
• 通讯作者: Sasisekharan,Ram