Core D: Neuropathology Core

核心 D：神经病理学核心

• 批准号: 9753837
• 负责人: Anthony Yachnis
• 金额: $ 13.55万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9753837
• 关键词: Alzheimer' s Disease; Archives; Autopsy; Biocompatible Materials; Biological Markers; Brain; Cerebrospinal Fluid; Clinic; Clinical; Clinical Research; Cognitive; Confidentiality of Patient Information; Consensus; Consent; DNA; Data; Databases; Diagnosis; Diagnostic; Disease; Disease Progression; Education; Evaluation; Florida; Freezing; Frontotemporal Lobar Degenerations; Gene Mutation; Genetic; Goals; Gold; Guidelines; Individual; Lewy Bodies; Medical center; National Institute on Aging; Needs Assessment; Nervous system structure; Neuraxis; Neurodegenerative Disorders; Neurofibrillary Tangles; Onset of illness; Participant; Pathologic; Pathology; Patients; Plasma; Practice Guidelines; Procedures; Proteins; Research; Research Personnel; Research Project Grants; Research Support; Resources; Sampling; Senile Plaques; Serum; Specimen; Time; Tissue Sample; Tissues; Universities; base; brain tissue; clinical Diagnosis; cohort; data management; disease diagnosis; genetic information; genetic risk factor; neuropathology; outreach; patient subsets; protein TDP-43; protein aggregate; recruit; symposium

SUMMARY (Core D) In order to support the goals of the University of Florida-Mount Sinai Medical Center Alzheimer s Disease Research Center (UF-MSMC ADRC) the Neuropathology Core (Core D) will perform diagnostic evaluations and quantitative analyses of the brains collected from deceased individuals that participate in the clinical studies. These are critical functions of an ADRC as a definite diagnosis of AD still requires a thorough post- mortem evaluation. The Neuropathology Core will also collect and provide genetic information, brain tissue samples, biospecimens and DNA that will be integrated within or utilized by other components of the UF- MSMC ADRC. The specific aims of the Neuropathology Core are: Aim 1. Perform brain autopsies on participants of the UF-MSMC ADRC in a timely fashion and in accordance with the National Institute on Aging-Alzheimer s Association consensus guidelines. Aim 2. Provide neuropathologic data and genetic information to be included in the database to support clinical studies. Aim 3. Collect and bank fixed and frozen brain specimens, DNA and biospecimens (plasma, serum and cerebrospinal fluid) in accordance with the biospecimen best practice guidelines. A final diagnosis will be achieved by clinic-pathological consensus conferences to be held monthly with the Clinical Core (Core B). This will also serve as an important educational component that will integrate with the Outreach, Recruitment and Education Core (Core E). Brain tissue and other biological materials collected will be stored and provided to support research projects from approved investigators of the UF-MSMC ADRC and to qualified external investigators as well as a portion being sent to NCRAD. Genetic data will be provided to NIAGADS and the neuropathologic data will be provided to the National Alzheimer Coordinating Center (NACC) through the Data Management and Statistical Core (Core C).

摘要（核心D） 为了支持佛罗里达大学西奈大学医学中心阿尔茨海默氏病的目标 研究中心（UF-MSMC ADRC）神经病理学核心（核心D）将执行诊断评估 以及对参与临床的死者个人收集的大脑的定量分析 研究。这些是ADRC作为AD的明确诊断的关键功能，仍然需要彻底的后 验尸评估。神经病理学核心还将收集和提供遗传信息，脑组织 样品，生物测量和DNA将在UF-的其他组件中集成或使用 MSMC ADRC。神经病理学核心的具体目的是：目标1。 UF-MSMC ADRC的参与者及时并按照国家研究所 老化 - 阿尔茨海默氏症协会共识指南。目标2。提供神经病理学数据和遗传 信息包含在数据库中以支持临床研究。目标3。收集和银行固定和 根据根据的冷冻脑标本，DNA和生物测量（血浆，血清和脑脊液） 生物测量最佳实践指南。临床病理共识将实现最终诊断 每月使用临床核心举行会议（核心B）。这也将成为重要的 教育组成部分将与外展，招聘和教育核心（核心E）融为一体。脑 收集的组织和其他生物材料将被存储并提供，以支持来自 批准的UF-MSMC ADRC和合格的外部调查人员以及一部分的调查员 被送到Ncrad。遗传数据将提供给Niagads，神经病理学数据将是 通过数据管理和统计，提供给国家阿尔茨海默氏症协调中心（NACC） 核心（核心C）。