Vascular Effects on Normal Neural and Cognitive Aging

血管对正常神经和认知衰老的影响

• 批准号: 8726263
• 负责人: Karen M Rodrigue
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF TEXAS DALLAS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8726263
• 关键词: Adult; Adverse effects; Affect; Age; Aging; Amyloid; Amyloid deposition; Automobile Driving; Award; Blood Vessels; Brain; Categories; Cerebrum; Chronic; Cognition; Cognitive; Cognitive aging; Control Groups; Core-Binding Factor; Data; Dementia; Deterioration; Development; Doctor of Philosophy; Early Diagnosis; Elderly; Ensure; Essential Hypertension; Exhibits; Functional Magnetic Resonance Imaging; Goals; Health; Hypertension; Impaired cognition; Impairment; Individual; Individual Differences; Knowledge; Lobe; Longevity; Maintenance; Measures; Medial; Memory; Mentors; Metabolic; Methodology; Mission; Modeling; National Institute on Aging; Nerve Degeneration; Neurocognitive; Nutrient; Oxygen; Participant; Pathway interactions; Pattern; Performance; Perfusion; Phase; Positioning Attribute; Positron-Emission Tomography; Prevalence; Prevention; Process; Psyche structure; Publishing; Recruitment Activity; Regional Perfusion; Research; Research Proposals; Risk; Risk Factors; Role; Sampling; Shapes; Short-Term Memory; Specificity; Structure; Testing; Training; Vascular System; Vascular blood supply; age related; aged; aging population; amyloid precursor protein processing; base; cerebrovascular; cognitive neuroscience; expectation; healthy aging; hypoperfusion; long term memory; middle age; normal aging; normotensive; novel; pathological aging; processing speed; programs; relating to nervous system; skills; vascular contributions; vascular risk factor

PROJECT SUMMARY ABSTRACT The objectives of this Pathway to Independence Award for Karen M. Rodrigue, Ph.D., are to deepen the candidate's expertise in the field of cognitive neuroscience to enable her to investigate novel questions regarding the role of vascular risk in brain and cognitive aging. The central aim of this project is to examine a vascular hypothesis of aging which investigates the role of general vascular risk factors, such as hypertension, and specific cerebrovascular mechanisms such as hypoperfusion, in shaping the course of neural and cognitive aging within a normal aging model. The proposed K99 phase of research focuses on this aim by testing the hypothesis that age-related alteration in regional brain perfusion predicts decline in the cognitive performance of healthy middle-aged and older adults. The mentored phase also examines the modifying effects of hypertension on neural activity in an fMRI paradigm, testing the hypothesis that differences in vascular health can explain age-related dedifferentiation of brain function. A cross-sectional individual differences approach with a lifespan sample will be used to test hypotheses in the K99 phase. The R00 phase extends the study of the impact of vascular health on neural and cognitive decline by examining vascular predictors of ¿-amyloid deposition in normal aging. The objectives of this research proposal are in accord with the mission of the National Institute on Aging. Understanding the contributions of vascular health to successful, as well as pathological aging is fundamentally important given both the prevalence of vascular risk in the aging population, and its amenability to prevention and treatment. The research skills and knowledge gained by the applicant during the completion of this project (e.g., training in fMRI, perfusion and PET imaging) along with the proposed coursework and professional development activities outlined in the training plan, will enable her to successfully transition to an independent position as a cognitive neuroscientist.

项目概要摘要 凯伦·M·罗德里格博士获得独立之路奖的目的是加深 候选人在认知神经科学领域的专业知识使她能够研究新问题 关于血管风险在大脑和认知衰老中的作用该项目的中心目的是研究血管风险。 衰老的血管假说研究一般血管危险因素的作用，例如高血压、 以及特定的脑血管机制，例如低灌注，在塑造神经和神经的过程中 正常衰老模型中的认知衰老是 K99 阶段研究的重点。 检验以下假设：区域脑灌注与年龄相关的变化可预测认知能力下降 指导阶段还检查了健康中年人和老年人的表现。 在功能磁共振成像范式中高血压对神经活动的影响，检验了以下假设： 血管健康可以解释与年龄相关的大脑功能去分化。 使用寿命样本的差异方法将用于检验 K99 阶段的假设。 通过检查血管，扩展了血管健康对神经和认知能力下降的影响的研究 的预测因子-正常衰老中的淀粉样蛋白沉积。本研究提案的目标符合。 国家老龄化研究所的使命了解血管健康对成功的贡献， 考虑到衰老过程中血管风险的普遍存在，病理性衰老也至关重要 人口及其对预防和治疗的适应性。 申请人在完成该项目期间（例如，功能磁共振成像、灌注和 PET 成像培训）以及 培训计划中概述的拟议课程和专业发展活动将使她能够 成功过渡到作为认知神经科学家的独立职位。

项目成果

BDNF val66met polymorphism affects aging of multiple types of memory.

BDNF val66met 多态性影响多种类型记忆的老化。

• 发表时间: 2015-07-01
• 影响因子: 2.9
• 作者: Kennedy, Kristen M;Reese, Elizabeth D;Horn, Marci M;Sizemore, April N;Unni, Asha K;Meerbrey, Michael E;Kalich Jr, Allan G;Rodrigue, Karen M
• 通讯作者: Rodrigue, Karen M

The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance.

血管健康因素对白质微观结构的影响介导了执行功能表现中与年龄相关的差异。

• 发表时间: 2021
• 作者: Hoagey, David A;Lazarus, Linh T T;Rodrigue, Karen M;Kennedy, Kristen M
• 通讯作者: Kennedy, Kristen M

Association between subjective memory assessment and associative memory performance: Role of ad risk factors.

主观记忆评估与联想记忆表现之间的关联：广告风险因素的作用。

• 发表时间: 2018-02
• 影响因子: 3.7
• 作者: Horn, Marci M;Kennedy, Kristen M;Rodrigue, Karen M
• 通讯作者: Rodrigue, Karen M

The role of hippocampal subfield volume and fornix microstructure in episodic memory across the lifespan.

海马亚区体积和穹窿微观结构在整个生命周期情景记忆中的作用。

• 发表时间: 2019
• 影响因子: 3.5
• 作者: Foster, Chris M;Kennedy, Kristen M;Hoagey, David A;Rodrigue, Karen M
• 通讯作者: Rodrigue, Karen M

Striatal iron content is linked to reduced fronto-striatal brain function under working memory load.

纹状体铁含量与工作记忆负荷下额叶纹状体大脑功能的降低有关。

• 发表时间: 2020
• 影响因子: 5.7
• 作者: Rodrigue, Karen M;Daugherty, Ana M;Foster, Chris M;Kennedy, Kristen M
• 通讯作者: Kennedy, Kristen M