Center of Com Med and Pathology

通讯医学与病理学中心

• 批准号: 8933484
• 负责人: NEIL SCOTT LIPMAN
• 金额: $ 245.05万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8933484
• 关键词: Anatomy; Animal Experimentation; Animal Model; Animals; Area; Basic Science; Biological; Cancer Center Support Grant; Caring; Clinical; Clinical Research; Comparative Pathology; Development; Diagnosis; Education; Ensure; Environment; Equipment; Genetic Engineering; Health; Housing; Individual; Instruction; Laboratories; Laboratory Research; Maintenance; Medicine; Memorial Sloan-Kettering Cancer Center; Methods; Monitor; Neoplasms; Online Systems; Pathology; Phenotype; Procedures; Quarantine; Research; Research Activity; Research Personnel; Resources; Rodent; Services; Surveys; Training; Translational Research; Vendor; Work; Writing; animal care; animal model development; animal resource; biosecurity; cancer therapy; clinical care; comparative; operation; pathogen; programs; quality assurance; square foot

The Center of Comparative Medicine and Pathology (CCMP) supports animal model development and use through its Research Animal Resource Center (RARC) and Laboratory of Comparative Pathology (LCP). At MSKCC, animal models are used in basic and applied investigational studies as well as for training of both clinical and research staff. Animals are employed in diverse areas including the development of new methods for diagnosis and treatment of cancer as well as the elucidation of the basic biological mechanisms resulting in neoplasia. CCMP's professional and paraprofesslonal staff (131 FTE) serve as a consultative and technical resource for MSKCC investigators on all matters related to animal research. RARC is comprised of four sections: 1) Biosecurity; 2) Education and Quality Assurance (EQA); 3) Husbandry and Operations (H&O); and 4) Veterinary Services (VS). RARC provides housing for and humane care to over 170,000 animals daily, utilized by 140 investigators. PARC's oversight of MSKCC's AAALAC-accredited, centrally managed, animal care program ensures the efficient use of available space and staff resources and allows for close professional monitoring of the animal research program. Biosecurity ensures that MSKCC's rodent colonies remain pathogen free by routinely surveying colony health and quarantining incoming rodents from vendors. EQA administers an extensive educational program which provides training to animal care and research staff via didactic and hands-on sessions, web based tutorials as well as written instructional materials. PARC's H&O section operates three specialized state-of-the-art facilities encompassing over 80,700 net square feet of space which provide critical environments and the specialized equipment necessary for the maintenance and use of a variety of animal models. VS's staff ensure that all animals' receive appropriate clinical care and perform technical procedures for research staff. The LCP, a multi-disciplinary pathology laboratory and its Genetically Engineered Animal (GEA) Phenotyping Service supports individual laboratory's research and PARC's programs by providing clinical and anatomic pathology services and extensive phenotypic profiles of GEA.

比较医学和病理学中心 (CCMP) 支持动物模型开发和 通过其研究动物资源中心 (RARC) 和比较病理学实验室使用 （LCP）。在 MSKCC，动物模型用于基础和应用研究以及 临床和研究人员的培训。动物被应用于不同领域，包括开发 癌症诊断和治疗的新方法以及基本生物学原理的阐明 导致肿瘤形成的机制。 CCMP 的专业人员和辅助专业人员 (131 FTE) 充当 为 MSKCC 研究人员提供与动物研究相关的所有事宜的咨询和技术资源。 RARC 由四个部分组成：1) 生物安全； 2）教育和质量保证（EQA）； 3） 畜牧和运营（H&O）； 4) 兽医服务 (VS)。 RARC 为以下人员提供住房： 每天对超过 170,000 只动物进行人道护理，由 140 名研究人员使用。 PARC 对 MSKCC 的监督 AAALAC 认证、集中管理的动物护理计划确保有效利用可用空间 和人力资源，并允许对动物研究计划进行密切的专业监控。生物安全 通过定期调查群体健康状况，确保 MSKCC 的啮齿动物群体保持无病原体状态 隔离来自供应商的啮齿动物。 EQA 管理着广泛的教育计划 通过教学和实践课程、基于网络的教程为动物护理和研究人员提供培训 以及书面教学材料。 PARC 的 H&O 部门拥有三个专业的最先进的 设施涵盖超过 80,700 净平方英尺的空间，提供关键环境和 维护和使用各种动物模型所需的专用设备。 VS的工作人员 确保所有动物得到适当的临床护理并为研究人员执行技术程序。 LCP，一个多学科病理学实验室及其基因工程动物 (GEA) 表型分析 服务通过提供临床和解剖学资料来支持各个实验室的研究和 PARC 的项目 GEA 的病理学服务和广泛的表型概况。