RARC- RESEARCH ANIMAL RESOURCE CENTER

RARC-研究动物资源中心

基本信息

批准号：
8602880
负责人：
NEIL SCOTT LIPMAN
金额：
$ 244.93万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-01-20 至 2013-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8602880
关键词：
Accreditation Analgesics Anatomy Anesthesia procedures Anesthetic Gases Anesthetics Animal Euthanasia Animal Experimentation Animal Model Animal Sources Animal Welfare Act Animals Applied Research Area Autopsy Basic Science Beds Biocompatible Materials Biological Body Fluids Cancer Center Support Grant Canis familiaris Caring Clinical Comparative Pathology Consultations Containment Decontamination Development Diagnosis Diagnostic Procedure Diagnostics Research Diet Disease Education Effectiveness Ensure Environment Equipment Evaluation Exclusion Exercise Fluoroscope Genetically Engineered Mouse Glass Hazardous Chemicals Health Health Services Health Status Housing Human IACUC Image Immunocompromised Host Individual Infectious Agent International Investigation Isoflurane Laboratories Laboratory Animal Medicine Laboratory Animals Laboratory Research Maintenance Malignant Neoplasms Medical center Memorial Sloan-Kettering Cancer Center Methods Microscope Modality Monitor Mycoplasma Neoplasms New York Operating Rooms Operative Surgical Procedures Oral Oryctolagus cuniculus Parasites Pathology Pharmacy facility Phenotype Physiology Play Policies Postoperative Period Preparation Procedures Process Quality Control Quarantine Radioisotopes Recovery Room Regulation Research Research Activity Research Personnel Research Support Resources Rodent Role Safety Sampling Science Sentinel Serologic tests Services Slice Source Sterilization Surgeon Surveys System Techniques Tissues Toxic effect Training United States National Institutes of Health United States Public Health Service Universities Vaporizer Vendor Veterinarians Virus Water Writing Xenograft procedure animal care animal facility animal model development animal resource arm cancer therapy clinical care computerized digital feeding feral guide for the care and use of laboratory animals imaging modality improved in vivo instrument medical schools microbial nonhuman primate nutrition operation pathogen programs quality assurance square foot treatment planning tumor wasting

项目摘要

The Research Animal Resource Center (RARC) supports animal model development and use at MSKCC. At MSKCC, animal models are used in basic and applied investigational studies. Animals are employed in diverse areas including the development of new methods for diagnosis and treatment of cancer, and the elucidation of the basic biological mechanisms resulting in neoplasia. RARC is comprised of six sections: 1.) Husbandry and Operations; 2.) Animal Health Service (AHS); 3.) Education and Quality Assurance (EQA); 4.) Laboratory of Comparative Pathology (LCP); 5.) Genetically Engineered Mouse Phenotyping (GEM) Core; and, 6.) Administration and Finance, which provide housing for and humane care to over 90,000 animals daily utilized by 99 research laboratories. RARC's oversight of MSKCC's AAALACaccredited, centrally managed, animal care and use program ensures the efficient use of available space and staff resources and allows for close professional monitoring of the in vivo (animal) research program. RARC operates three specialized state-of-the-art facilities encompassing over 66,000 net square feet of space which provide critical environments and the specialized equipment necessary for the maintenance and use of a variety of animal models. RARC's board-certified professional and paraprofessional staff (83 FTE) serve as a consultative and technical resource for MSKCC investigators on all matters related to animal research, The AHS's veterinary and veterinary technical staff ensure that all animals' receive appropriate clinical care and ensure that MSKCC's rodent colonies remain pathogen free by routinely surveying colony health and quarantining all incoming rodents from atypical vendors. Additionally, AHS staff perform technical procedures for research staff in support of their animal research programs. The LCP and the GEM core provide clinical and anatomic pathology services which ensure the health of the resident colonies but are also used extensively in support of individual laboratory's research programs. RARC's extensive educational program is administered by the EQA section which provides training to research staff via didactic and hands-on sessions as well as various written instructional materials. RARC also provides post-graduate training to veterinarians in both Laboratory Animal Medicine and Science, and Comparative Pathology in conjunction with the Weil Medical College of Cornell University, the Rockefeller University, and the Animal Medical Center.

研究动物资源中心 (RARC) 支持 MSKCC 的动物模型开发和使用。在 MSKCC，动物模型用于基础和应用研究。动物被雇佣于不同的领域，包括开发癌症诊断和治疗的新方法，以及阐明导致肿瘤形成的基本生物学机制。 RARC 由六个部分组成： 1.) 饲养和运营； 2.) 动物健康服务局 (AHS)； 3.) 教育和质量保证（EQA）； 4.) 比较病理学实验室（LCP）； 5.) 基因工程小鼠表型分析（创业板）核心； 6.) 行政和财务，为以上人员提供住房和人文关怀 99 个研究实验室每天使用 90,000 只动物。 RARC 监督 MSKCC 的 AAALAC 认证，集中管理的动物护理和使用计划确保有效利用可用空间和人力资源，并允许对体内（动物）研究计划进行密切的专业监控。 RARC 运营着三个专业的最先进设施，占地超过 66,000 净平方英尺提供关键环境和维护所需的专用设备的空间以及多种动物模型的使用。 RARC 经董事会认证的专业人员和辅助专业人员 (83 FTE）作为 MSKCC 调查人员在所有相关事宜上的咨询和技术资源动物研究中，AHS 的兽医和兽医技术人员确保所有动物都接受适当的临床护理并确保 MSKCC 的啮齿动物群落保持无病原体状态调查群体健康状况并隔离所有来自非典型供应商的啮齿动物。此外，AHS 工作人员为研究人员执行技术程序以支持他们的动物研究计划。 LCP 和 GEM核心提供临床和解剖病理学服务，确保居民的健康菌落，但也广泛用于支持单个实验室的研究项目。拉克的 EQA 部门负责管理广泛的教育计划，为研究人员提供培训通过教学和实践课程以及各种书面教学材料。 RARC 还为兽医提供实验动物医学和科学和比较病理学与康奈尔大学威尔医学院合作，洛克菲勒大学和动物医学中心。