Visible Light Photocatalysis

可见光光催化

• 批准号: 9380341
• 负责人: TEHSHIK P YOON
• 金额: $ 35.92万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2018-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9380341
• 关键词: Acids; Adoption; Alkenes; Anions; Architecture; Biological; Catalysis; Cations; Chemicals; Chemistry; Communities; Complex; Cyclobutanes; Development; Electron Transport; Energy Transfer; Equipment; Generations; Household; Industrialization; Investigation; Laboratories; Life; Methodology; Methods; Modernization; Molecular; Molecular Medicine; Molecular Structure; Outcome; Pharmaceutical Preparations; Pharmacologic Substance; Photochemistry; Process; Property; Reaction; Reporting; Research; Research Personnel; Route; Savings; Source; Structure; Sunlight; Thermodynamics; Time; Transition Elements; Triplet Multiple Birth; Visible Radiation; chemical synthesis; cycloaddition; drug candidate; drug discovery; innovation; interest; irradiation; metal complex; next generation; nitrene; novel; novel strategies; oxetane; prevent; programs; public health relevance; scaffold; stereochemistry

DESCRIPTION (provided by applicant): Photochemical reactions are attractive for drug discovery because they enable the synthesis of unusual, strained molecular frameworks that cannot be synthesized by other methods. Nevertheless, pharmaceutical companies rarely take advantage of photochemical synthesis because the need for specialized photochemical equipment is an impractical impediment and because very few methods to control the stereochemistry of photochemical reactions exist. Therefore, the structures of the molecules that are produced by photochemical synthesis have essentially not been examined as possible drug candidates. Our laboratory has pioneered a new approach to photochemical synthesis that uses convenient, readily available sources of visible light (e.g., household lightbulbs, ambient sunlight) in order to make photochemical synthesis accessible to medicinal chemists for the first time. This Proposal has two parallel objectives: Aim 1. The development of strategies to control the stereochemistry of photochemical reactions. Aim 2. The development of a novel mechanism of photochemical activation with visible light. These methods are powerful, robust, and simple to perform on large, industrially relevant scales. Thus, the research described in this proposal will significantly impact both the academic chemistry community and the broader community of medicinal chemists who require new methods of molecule construction to discover the next generation of life-saving drugs.

描述（由申请人提供）：光化学反应对于药物发现很有吸引力，因为它们能够合成其他方法无法合成的不寻常的、紧张的分子框架。然而，制药公司很少利用光化学合成，因为需要专门的光化学设备是一个不切实际的障碍，而且控制光化学反应立体化学的方法很少。因此，通过光化学合成产生的分子的结构基本上尚未作为可能的候选药物进行检查。我们的实验室开创了一种新的光化学合成方法，该方法使用方便、容易获得的可见光源（例如家用灯泡、环境阳光），以便首次使药物化学家能够进行光化学合成。该提案有两个并行的目标： 目标 1. 开发控制光化学反应立体化学的策略。目标 2. 开发可见光光化学激活的新机制。这些方法功能强大、稳健且易于在工业相关的大规模规模上执行。因此，该提案中描述的研究将对学术化学界和更广泛的药物化学家产生重大影响，他们需要新的分子构建方法来发现下一代救生药物。