BLR&D Research Career Scientist Award Application

BLR

• 批准号: 9338937
• 负责人: Nihal Ahmad
• 金额: --
• 依托单位: WM S. MIDDLETON MEMORIAL VETERANS HOSP
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9338937
• 关键词: Academia; Affect; Afghanistan; Antioxidants; Area; Award; Berry; Biochemical; Biochemistry; Biology; Book Chapters; Cancer Biology; Chemopreventive Agent; Clinical; Collaborations; Country; Deacetylase; Department of Defense; Dermatologic; Dermatology; Development; Dioxins; Event; Extramural Activities; Faculty; Family; Funding; Funding Agency; Goals; Grant; Grapes; Hand; Healthcare; Herbicides; Human; Incidence; Industry; Institutes; International; Investigational Therapies; Iraq; Journals; Laboratories; Lead; Life; Malignant Neoplasms; Malignant neoplasm of prostate; Melatonin; Mentors; Micronutrients; Middle East; Military Personnel; Mission; Mitotic; Molecular; Names; Neoplasms; Nicotinamide adenine dinucleotide; Nuts; Oncogenes; PLK1 gene; Paper; Peer Review; Peer Review Grants; Pharmacology; Photobiology; Photochemistry; Pineal gland; Population; Positioning Attribute; Postdoctoral Fellow; Prevention; Protein Family; Protein-Serine-Threonine Kinases; Publications; Publishing; Radiation; Reporting; Research; Resveratrol; Risk; Role; Scientist; Selenium; Services; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Sirtuins; Skin Cancer; Source; Study Section; Therapeutic; Toxicology; Training; United States National Institutes of Health; Universities; Veterans; Vietnam; Vitamin E; Wisconsin; Work; World War II; anticancer research; base; career; editorial; graduate student; improved; indexing; interest; meetings; melanoma; member; novel strategies; operation; phytoalexins; red wine; symposium; tumor progression; ultraviolet irradiation; undergraduate student

My long-term career goal is to improve the quality of human life, including that of Veterans, through my research. My laboratory focuses on two broad and complimentary research areas: 1) cancer biology and 2) prevention and experimental therapeutics of cancer. My overall goal is to define the critical molecular and biochemical events that occur during cancer development that in turn will assist in identifying targets and new approaches and strategies for cancer management. While interested in cancer in general, my recent focus has been on skin and prostate cancers, both of which disproportionally affect the Veteran population. Examples of ongoing research in my laboratory are as follows. We are studying the role and functional significance of mitotic regulators, including the polo-like kinase (Plk) family of serine/threonine kinases, and how these factors interact with other important cell signaling pathways to influence cancer development and progression. In addition, we are trying to understand the role of nicotinamide adenine dinucleotide (NAD)+ -dependent deacetylases, namely the Sirtuin family proteins, in the development and/or progression of cancer. The second major focus of my research is to define the cancer chemopreventive/therapeutic potential of a variety of agents, such as resveratrol (a phytoalexin antioxidant found in grapes, nuts, berries and red wine), melatonin (the chief secretory product of the pineal gland and a known antioxidant), vitamin E (the major antioxidant in biomembranes) and selenium (an essential micronutrient for humans). My current VA-sponsored research focuses on identifying the mechanism of melanoma development and progression. This research area is extremely relevant to VA healthcare as the U.S. military engages in missions all over the world, including in the Middle East (Iraq and Afghanistan). Deployment to these regions results in significant UV irradiation exposure that increases the risk for malignant melanoma in the Veterans returning from these areas. Based on several studies, an increased incidence of melanoma was reported for World War II Veterans stationed in the Pacific and those exposed to dioxin-contaminated herbicides during Operation Ranch Hand in Vietnam. My ongoing research aims at defining the molecular mechanism of melanoma development. I believe that my research findings are moving towards the identification of novel strategies for the management of this deadly neoplasm. Thus, my work is relevant and significant to Veteran's healthcare and is in line with the mission of the Department of Veterans Affairs. The results of my research are published in a wide range of high-impact scientific journals. I have published more than 170 papers, 150 abstracts and several book chapters (Total Citations: 17,705; h-index, 65; i10-index: 1256 Source: Google Scholar; 8/2016). I serve as an Associate Editor of two well-respected journals, Toxicology and Applied Pharmacology and Photochemistry and Photobiology, and am a member of the Editorial Board of several other journals. I am regularly invited to participate in the peer-review of grants for national and international funding agencies, including the Department of Veterans Affairs, National Institutes of Health, and the Department of Defense. I am currently a regular member of the Radiation Therapeutics and Biology (RTB) Study Section of the NIH. I mentored numerous junior scientists at all levels (undergraduate, graduate, post-doctoral, and junior faculty). Many of my previous trainees/mentees have successfully obtained independent positions in academics and industry. In addition, I extensively collaborated with numerous scientists within the VA as well as at the University of Wisconsin, other universities in the U.S., and outside the country (internationally). I have always believed in the notion that `two heads are better than one'. A majority of my collaborations have been very successful, resulting in numerous papers and extramural funding. In summary, I believe that I am well qualified for the BLR&D Merit Review Research Career Scientist (RCS) Award, and I appreciate your consideration of my application.

我的长期职业目标是通过我的努力提高人类的生活质量，包括退伍军人的生活质量 研究。我的实验室专注于两个广泛且互补的研究领域：1) 癌症生物学和 2) 癌症的预防和实验治疗。我的总体目标是定义关键的分子和 癌症发展过程中发生的生化事件反过来将有助于确定目标和新的 癌症管理的方法和策略。虽然总体上对癌症感兴趣，但我最近的重点是 皮肤癌和前列腺癌，这两种癌症对退伍军人群体的影响不成比例。的例子 我的实验室正在进行的研究如下。我们正在研究的作用和功能意义 有丝分裂调节因子，包括丝氨酸/苏氨酸激酶的 Polo 样激酶 (Plk) 家族，以及这些因子如何发挥作用 与其他重要的细胞信号通路相互作用，影响癌症的发生和进展。在 此外，我们正在尝试了解烟酰胺腺嘌呤二核苷酸 (NAD)+ 依赖性的作用 脱乙酰酶，即 Sirtuin 家族蛋白，在癌症的发生和/或进展中发挥作用。第二个 我研究的主要重点是确定各种癌症的化学预防/治疗潜力 制剂，例如白藜芦醇（一种存在于葡萄、坚果、浆果和红酒中的植物抗氧化剂）、褪黑激素 （松果体的主要分泌产物，也是一种已知的抗氧化剂）、维生素 E（体内的主要抗氧化剂） 生物膜）和硒（人类必需的微量营养素）。我目前由 VA 资助的研究 专注于确定黑色素瘤发生和进展的机制。该研究领域是 由于美国军队在世界各地执行任务，包括在 中东（伊拉克和阿富汗）。部署到这些地区会导致大量的紫外线照射 这增加了从这些地区返回的退伍军人患恶性黑色素瘤的风险。基于几个 研究表明，驻扎在太平洋地区的二战退伍军人的黑色素瘤发病率有所增加 以及在越南“牧场工人行动”期间接触受二恶英污染的除草剂的人。我正在进行的 研究旨在明确黑色素瘤发展的分子机制。我相信我的研究 研究结果正在朝着确定治疗这种致命肿瘤的新策略的方向发展。 因此，我的工作与退伍军人的医疗保健相关且具有重要意义，并且符合该协会的使命 退伍军人事务部。我的研究成果广泛发表在高影响力的杂志上 科学期刊。我发表了 170 多篇论文、150 篇摘要和几本书章节（总计 引用次数：17,705； h 指数，65； i10-指数：1256 来源：谷歌学术； 8/2016）。 我担任毒理学和应用药理学两本备受推崇的期刊的副主编 光化学和光生物学，并且是其他几个期刊的编辑委员会成员。我是 定期受邀参加国家和国际资助机构赠款的同行评审， 包括退伍军人事务部、国立卫生研究院和国防部。我 我目前是 NIH 放射治疗和生物学 (RTB) 研究部门的正式成员。 我指导过许多各个级别的初级科学家（本科生、研究生、博士后和初级科学家） 学院）。我以前的许多学员/学员都成功获得了独立职位 学术界和工业界。此外，我还与 VA 内的许多科学家进行了广泛的合作 与威斯康星大学、美国其他大学以及国外（国际）一样。我有 始终相信“两个头脑比一个头脑好”的观念。我的大部分合作都是 非常成功，产生了大量论文和校外资金。 总而言之，我相信我完全有资格成为 BLR&D Merit Review 研究职业科学家 （RCS）奖，感谢您考虑我的申请。