BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

• 批准号: 10593106
• 负责人: Nihal Ahmad
• 金额: --
• 依托单位: WM S. MIDDLETON MEMORIAL VETERANS HOSP
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2029-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593106
• 关键词: Academia; Affect; Afghanistan; Antioxidants; Area; Award; Berry; Biochemical; Biology; Book Chapters; Cancer Biology; Cancer Patient; Carcinoma; Chemopreventive Agent; Clinical; Collaborations; Country; Data; Deacetylase; Department of Defense; Dermatology; Development; Dioxins; Environment; Event; Exposure to; Extramural Activities; Faculty; Family; Funding; Funding Agency; Goals; Grapes; Hand; Healthcare; Herbicides; Human; Incidence; Industry; International; Investigational Therapies; Iraq; Journals; Laboratories; Life; Malignant Neoplasms; Malignant neoplasm of prostate; Melatonin; Mentors; Micronutrients; Middle East; Military Personnel; Mission; Mitotic; Molecular; Names; Neoplasms; Nicotinamide adenine dinucleotide; Nuts; Oncogenes; Oncology; PLK1 gene; Paper; Peer Review Grants; Pharmacology; Photobiology; Photochemistry; Pineal gland; Positioning Attribute; Postdoctoral Fellow; Prevention; Protein Family; Protein-Serine-Threonine Kinases; Publishing; Qualifying; Radiation; Reporting; Research; Research Personnel; Resveratrol; Risk; Role; Scientist; Selenium; Serine; Services; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Sirtuins; Skin Cancer; Source; Study Section; Therapeutic; Toxicology; UV Radiation Exposure; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Veterans; Veterans Health Administration; Vietnam; Vitamin E; Wisconsin; Work; World War II; anticancer research; cancer diagnosis; career; druggable target; editorial; experience; frontier; improved; indexing; interest; melanoma; member; military veteran; neoplasm registry; novel; novel strategies; operation; phytoalexins; red wine; tumor progression; ultraviolet irradiation; undergraduate student; Academia; Affect; Afghanistan; Antioxidants; Area; Award; Berry; Biochemical; Biology; Book Chapters; Cancer Biology; Cancer Patient; Carcinoma; Chemopreventive Agent; Clinical; Collaborations; Country; Data; Deacetylase; Department of Defense; Dermatology; Development; Dioxins; Environment; Event; Exposure to; Extramural Activities; Faculty; Family; Funding; Funding Agency; Goals; Grapes; Hand; Healthcare; Herbicides; Human; Incidence; Industry; International; Investigational Therapies; Iraq; Journals; Laboratories; Life; Malignant Neoplasms; Malignant neoplasm of prostate; Melatonin; Mentors; Micronutrients; Middle East; Military Personnel; Mission; Mitotic; Molecular; Names; Neoplasms; Nicotinamide adenine dinucleotide; Nuts; Oncogenes; Oncology; PLK1 gene; Paper; Peer Review Grants; Pharmacology; Photobiology; Photochemistry; Pineal gland; Positioning Attribute; Postdoctoral Fellow; Prevention; Protein Family; Protein-Serine-Threonine Kinases; Publishing; Qualifying; Radiation; Reporting; Research; Research Personnel; Resveratrol; Risk; Role; Scientist; Selenium; Serine; Services; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Sirtuins; Skin Cancer; Source; Study Section; Therapeutic; Toxicology; UV Radiation Exposure; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Veterans; Veterans Health Administration; Vietnam; Vitamin E; Wisconsin; Work; World War II; anticancer research; cancer diagnosis; career; druggable target; editorial; experience; frontier; improved; indexing; interest; melanoma; member; military veteran; neoplasm registry; novel; novel strategies; operation; phytoalexins; red wine; tumor progression; ultraviolet irradiation; undergraduate student

This proposed Research Career Scientist award is to support the activities of Dr. Nihal Ahmad, an established Department of Veterans Affairs (VA) investigator, allowing him to expand his scientific, mentoring and service contributions. Dr. Ahmad’s long-term goal is to improve the quality of human life, including that of Veterans, through my research. Dr. Ahmad’s laboratory focuses on two broad and complementary research areas: 1) cancer biology and 2) prevention and experimental therapeutics of cancer. The major goal of his ongoing research is to define the critical molecular and biochemical events that occur during cancer development and progression to help identify novel targets and strategies for cancer management. While Dr. Ahmad’s laboratory is involved in understanding epithelial cancer in general, his major recent focus has been on skin- and prostate- cancers, both of which disproportionally affect the Veteran population. Dr. Ahmad’s current VA sponsored research focuses on identifying the mechanism of melanoma development and progression. Importantly, melanoma is among the five most frequently diagnosed cancers among VA cancer patients. In addition, the US military engages in missions all over the world, including recently in the Middle East (Iraq and Afghanistan). Deployment to these regions is associated with significant UV radiation exposure that increases the risk for malignant melanoma in the Veterans returning from these areas. Thus, Dr. Ahmad’s research findings may lead to identification of novel strategies for the management of this deadly neoplasm; and is relevant and significant to the health care of Veterans and directly in line with the mission of the Department of Veterans Affairs. The results of Dr. Ahmad’s research are published in a wide range of high-impact scientific journals. He has published more than 208 papers, 176 published abstracts and several book chapters (I have published more than 208 papers, 176 published abstracts and several book chapters (Total Citations: 28,413; h-index, 83; i10-index: 172; Source: Google Scholar; 08/2021). Dr. Ahmad is internationally recognized researcher. He serves as an Associate Editor of multiple well- respected journals, namely Toxicology and Applied Pharmacology, Journal of Oncology, Journal of Skin Cancer, and Frontiers in Oncology and Photochemistry and Photobiology, and he is a member of the Editorial Board for several other journals. He is regularly invited to participate in the peer-review of grants for national and international funding agencies, including the National Institutes of Health and the Department of Defense. He has recently completed his term as a Charter Member of the Radiation Therapeutics and Biology (RTB) Study Section of the NIH. In addition, he has mentored numerous junior scientists at all levels (undergraduate, graduate, post-doctoral, and junior faculty). Most of his previous trainees/mentees have been successful in obtaining independent positions in academia and industry. In addition, Dr. Ahmad has developed extensive collaborations with numerous scientists within the VA and at the University of Wisconsin, other universities in the US, and outside the country (internationally). Most of his collaborations have been very successful resulting in numerous papers and extramural funding.

这项拟议的研究职业科学家奖是为了支持Nihal Ahmad博士的活动 成立的退伍军人事务部（VA）调查员，允许他扩大他的科学，心理 和服务贡献。艾哈迈德博士的长期目标是提高人类生活的质量，包括 退伍军人，通过我的研究。艾哈迈德博士的实验室专注于两项广泛而完整的研究 区域：1）癌症生物学和2）癌症的预防和实验疗法。他的主要目标 正在进行的研究是定义癌症期间发生的关键分子和生化事件 开发和发展，以帮助确定癌症管理的新颖目标和策略。而博士 艾哈迈德的实验室一般参与了解上皮癌，他最近的重点是 在皮肤和前列腺癌中，这两者都不会影响退伍军人人口。 艾哈迈德（Ahmad）目前的VA赞助研究重点是确定黑色素瘤的机制 发展和发展。重要的是，黑色素瘤是最常诊断的癌症之一 在VA癌症患者中。此外，美军从事世界各地的任务，包括 最近在中东（伊拉克和阿富汗）。向这些地区的部署与重要相关 紫外线辐射暴露增加了退伍军人的恶性黑色素瘤的风险 区域。艾哈迈德博士的研究结果可能会导致对管理的新策略的识别 这个致命的肿瘤；并且与退伍军人的卫生保健相关，并且直接与 退伍军人事务部的任务。艾哈迈德博士的研究结果在广泛的 一系列高影响力的科学期刊。他发表了208多篇论文，176篇发表摘要和 几本书章节（我发表了208多篇论文，176篇发表摘要和几本书 章节（总引用：28,413; H-Index，83; i10-Index：172;资料来源：Google Scholar; 08/2021）。 艾哈迈德博士是国际认可的研究员。他是多个善良的副编辑 受人尊敬的期刊，即毒理学和应用药理学，肿瘤学杂志，皮肤杂志 癌症，肿瘤学和光化学和光生物学领域，他是社论的成员 董事会用于其他几个期刊。经常邀请他参加国家的赠款的同行评审 以及包括国立卫生研究院和国防部在内的国际资助机构。 他最近完成了辐射治疗和生物学（RTB）的特许成员的任期 NIH研究部分。此外，他还指导了各个级别的众多初级科学家（本科， 研究生，博士后和初级教师）。他以前的大多数培训/受训者都成功了 在学术界和工业中获得独立职位。此外，艾哈迈德博士发展了广泛的 与弗吉尼亚州和威斯康星大学的众多科学家合作， 美国以及国外（国际上）。他的大多数合作都非常成功 导致许多论文和校外资金。