Pilot Projects and Trans-Network Activities Core

试点项目和跨网络活动核心

• 批准号: 9446709
• 负责人: John F. Dipersio
• 金额: $ 25.44万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9446709
• 关键词: Advisory Committees; Advocate; Applied Research; Award; Basic Science; Biological Markers; Cancer Center; Cancer Therapy Evaluation Program; Clinical Trials; Conflict of Interest; Development; Early Therapeutic-Clinical Trials Network; Electronic Mail; Fostering; Funding; Goals; Grant; Institution; Leadership; Life; Malignant Neoplasms; Mentors; Mission; Modeling; Newsletter; Patients; Phase; Pilot Projects; Pre-Clinical Model; Process; Recommendation; Recruitment Activity; Reproducibility; Request for Applications; Research; Research Methodology; Research Personnel; Research Project Grants; Review Committee; Scientist; Solid Neoplasm; Testing; Translating; Translational Research; Underrepresented Minority; Universities; Validation; Washington; Woman; Work; anticancer research; base; human disease; innovation; member; minority investigator; patient subsets; pre-clinical; programs; research and development

Project Summary/Abstract: Pilot Projects and Trans-Network Activities Core The goal of the Pilot Projects and Trans-Network Activities Core is to support the development of research projects using PDX models that will advance the mission of the PDTC and PDXNet. The core will help to foster collaborative, translational research using well-characterized PDX models that recapitulate human disease. Projects will expand the scope of translational research and increase the number of investigators committed to testing CTEP agents using PDX models for developing the preclinical justification needed for Phase I/II clinical trials. Requests for Application (RFA) for two awards of $50,000 dollars a year will be solicited. One within the PDTC and one that is open to non-PDXNet members. The goal of these projects will be to support the translational goals of the PDTC to advance translational research through the use of PDX models or, research methods to enhance experimental validation and reproducibility across PDTCs. Requests for Applications (RFA) for PDX based projects will be requested annually. All developmental research project applications will be reviewed by Pilot Research Program Advisory Committee consisting of scientists (representing basic and applied science) with expertise in solid tumor cancers, a biostatistician, a patient advocate, and ad hoc members, as necessary (special expertise, no conflict of interest). This committee will make recommendations to the PDTC Leadership Committee, which will make final funding decisions. Relevance The work proposed will lead to increased utilization of PDXs as models of human disease that can be used as the preclinical justification for testing CTEP agents in patient sub-populations based on biomarkers.

项目摘要/摘要：试点项目和跨网络活动核心 试点项目和跨性网络活动的目标核心是支持研究的发展 使用PDX模型的项目将推进PDTC和PDXNET的任务。核心将有助于培养 合作，转化研究使用概括人类疾病的特征良好的PDX模型。 项目将扩大转化研究的范围，并增加致力于的调查人员的数量 使用PDX模型测试CTEP剂来开发I/II期临床所需的临床前依据 试验。将要求征集申请要求（RFA）两次奖励50,000美元的奖励。其中一个 PDTC和向非PDXNET成员开放的PDTC。这些项目的目标是支持 PDTC的转化目标通过使用PDX模型或研究 增强PDTC的实验验证和可重复性的方法。申请请求 （RFA）针对基于PDX的项目每年要求。所有发展研究项目申请将 由试点研究计划咨询委员会审查，该咨询委员会由科学家组成（代表基本和 应用科学）具有实体瘤癌的专业知识，生物统计学家，患者倡导者和临时 成员，必要时（特殊专业知识，没有利益冲突）。该委员会将提出建议 致PDTC领导委员会，该委员会将做出最终的资金决定。 关联 提出的工作将导致PDX作为人类疾病模型的利用增加，可以用作 基于生物标志物的患者亚群中测试CTEP剂的临床前依据。