Multi Source E-Beam kV X-Ray Tube for Image-Guided Radiotheraphy

用于图像引导放射治疗的多源电子束 kV X 射线管

• 批准号: 9750326
• 负责人: DOUGLAS P BOYD
• 金额: $ 21.82万
• 依托单位: IMATREX INC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2018-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9750326
• 关键词: Multi; Source; Beam; kV; Ray

 DESCRIPTION (provided by applicant): This project will develop a commercial product that will enable for the first time realtime tumor tracking during radiotherapy at an attractive price point and with minimal interference with standard clinical practice. The key novel technology is an optimized multi-source X-ray tube with 19 focal spots that is placed below the multi-leaf collimator (MLC) of a radiotherapy system as shown below. By steering a focused electron beam (e-beam) on a series of 19 cooled tungsten targets in sequence, this system will provide a set of projection images that can be reconstructed into a 20 cm × 20 cm × 20 cm digital tomosynthesis (DTS) volume image that surrounds the radiation target. The projection X-rays are captured by a universal kV-MV imager that can record portal MV images interlaced with the sequence of tomographic kV images. Since the sources are positioned around the perimeter of the MLC, the resulting tomographic cross section images are aligned perpendicular to the axis of the therapy beam. This geometry is referred to as "Beam's Eye View" imaging. The DTS images will be used to provide precise reference coordinates of a tumor surface for programming of the MLC, in near real-time. The preliminary specifications for the system indicate that a repetition rate of 2-3 volume images per second with near 1 mm spatial resolution will be possible. The multi-source e-beam X-ray tube will be developed by substantially the same premier team who developed the original Imatron EBCT scanners and the more recent e-beam luggage scanner. The e-beam team consisting of TeleSecurity Sciences, Inc. scientists, consultants, and vendors has partnered with the premier cone beam CT team at UC Davis along with a key Varian consultant, who are authorities on flat panel X-ray imagers, and in particular the Side-view of the TumoTrakTM in a Truebeam gantry kV-MV imager that will be used in this project to provide simultaneous MV portal imaging with interlaced kV DTS imaging of the tumor position. Phase 1 of the project extended the preliminary work to more precisely define the final design specifications for a future commercial system that will be appropriate for the entire radiotherapy industry. Phase 2 funding will develop a suitable prototype of the multi-source eBeam X-ray tube which will demonstrate the feasibility and performance of the commercial system. The majority of radiotherapy vendors have provided guidance and letters of support for this project. The commercial implementation of the proposed system in future radiotherapy systems will permit treatment plans that will have far improved localization of radiation exposure within reduced margins beyond the apparent boundaries of a malignant mass with a corresponding reduction in exposure to surrounding normal structures. This will be especially important in treating tumors of the chest and upper abdomen during free breathing where periodic motion in the range of 2 cm to 5 cm is often encountered.

 描述（由应用程序提供）：该项目将开发一种商业产品，该商品将在放射治疗期间首次以有吸引力的价格进行实时肿瘤跟踪，并且对标准临床实践的干扰最少。关键的新型技术是一种优化的多源X射线管，具有19个焦点斑点，其放置在放射疗法系统的多叶准准直仪（MLC）下方，如下所示。通过将聚焦的电子束（E-BEAM）转向一系列19个冷却的钨靶，该系统将提供一组投影图像，可以将其重构为20 cm x 20 cm x 20 cm x 20 cm数字间压合成（DTS）体积图像，以围绕辐射目标。投影X射线是由通用KV-MV成像仪捕获的，该图像可以记录与层析成像KV图像序列相交的门户MV图像。由于源位于MLC周围的位置，因此所得的层析成像横截面图像垂直于治疗束的轴线对齐。该几何形状被称为“横梁的眼睛视图”成像。 DTS图像将用于提供肿瘤表面的精确参考坐标，以实时实时地编程MLC。该系统的初步规格表明，将有可能具有接近1 mm空间分辨率的每秒2-3次体积图像的重复率。多源电子束X射线管将由开发原始的Imatron EBCT扫描仪和更新的E-Beam行李箱扫描仪的主要团队开发。由电视科学科学，Inc。的E梁团队与UC Davis的总理Cone Beam CT团队以及一位关键的Varian顾问合作，他们是平面X射线图像的当局，尤其是在Trumotraktm中使用Truebem kne the the the the the the the Imaging Imav-mv imav-imv-imave imavemv-imavemifiagniage imaviaus的当局。交错的肿瘤位置的KV DTS成像。该项目的第1阶段扩展了初步工作，以更精确地定义了未来商业系统的最终设计规范，这将适合整个放射治疗行业。第2阶段的资金将开发出多源EBEAM X射线管的合适原型，该原型将证明商业系统的可行性和性能。大多数放射治疗供应商都为该项目提供了指导和支持信。未来放射疗法系统中提出的系统的商业实施将允许治疗计划，该计划将在降低的边缘降低的辐射曝光度上，超出了恶性肿瘤的明显边界，并且相应地减少了周围正常结构的暴露。这对于在自由呼吸过程中处理胸部和上腹部的肿瘤尤其重要，在自由呼吸中，经常遇到2厘米至5 cm的周期性运动。

项目成果

Dosimetry of a novel converging X-ray source for kilovoltage radiotherapy.

• DOI: 10.1002/mp.15167
• 发表时间: 2021-10
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Stalbaum T;Partain L;Weil MD;Kim J;Han JY;Plies MJ;Chen H;Ziskin V;Bazalova-Carter M;Song S;Rand R;Boyd D
• 通讯作者: Boyd D