High-speed Intraoperative Assessment of Breast Tumor Margin using MarginPAT

使用 MarginPAT 高速术中评估乳腺肿瘤边缘

基本信息

批准号：
9443729
负责人：
Ji-Xin Cheng
金额：
$ 5万
依托单位：
VIBRONIX, INC.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-25 至 2017-08-24
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9443729
关键词：
3-Dimensional Address Adipose tissue Algorithms Area Biological Neural Networks Blood Breast Breast Cancer Treatment Breast-Conserving Surgery Chemicals Classification Client satisfaction Clinical Clinical Research Cytology Data Detection Development Devices Diffuse Dimensions Doctor of Philosophy Economics Ensure Evaluation Fatty acid glycerol esters Feasibility Studies Fibrosis Frequencies Frozen Sections Goals Gold Health Histology Human Image Information Systems Lasers Lead Lipids Malignant Neoplasms Mammary Gland Parenchyma Mammary Neoplasms Maps Measures Methods Modality Names Normal tissue morphology Operating Rooms Optical Coherence Tomography Optics Phase Physiologic pulse Preparation Procedures Raman Spectrum Analysis Research Resected Residual Cancers Residual Tumors Resolution Sampling Scanning Sensitivity and Specificity Signal Transduction Specificity Specimen Spectrum Analysis Speed Surface Surgeon Surgical margins System Technology Testing Time Tissue Sample Tissues Training Ultrasonography Validation base breast lesion breast lumpectomy cherenkov imaging cost design imaging system improved innovation malignant breast neoplasm mechanical properties miniaturize multimodality nanosecond operation optoacoustic tomography photoacoustic imaging prevent radio frequency spectroscopic imaging tissue phantom tool tumor tumor specificity

项目摘要

After a breast conserving therapy, histology is often performed to check whether the excised tumor specimen is surrounded by a sufficient amount of normal tissue. If a positive margin is identified, then a second operation will be performed. Currently, the re-operation rate is 20-40%, which raises a need for intraoperative detection of residual cancers. The current intraoperative tools for margin assessment are time consuming and lack sufficient tumor specificity. Multiple emerging optical technologies improved the sensitivity and specificity but still suffered from a long procedure time. We propose a multi-modal spectroscopic photoacoustic/ultrasound imaging system to differentiate cancer and normal tissue in a resected breast tissue. Providing both chemical content and mechanical property information, this system, named MarginPAT, is able to measure map tissue components including blood, fat, fibrosis tissue, and breast lesion. Based on a compact Raman laser and a high-speed scanning chamber, the proposed MarginPAT system is able to scan 10 cm2 tissue area per min, which is faster than the frozen section analysis (gold standard for intraoperative assessment) by one order of magnitude. Such capacities allow 3 dimensional assessment of margin status in the entire excised tissue with >90% sensitivity and specificity.

经过乳房保存治疗后，经常进行组织学以检查是否是否切除的肿瘤标本被足够数量的正常组织所包围。如果确定了正边距，则将执行第二个操作。目前，连续操作率为20-40％，这增加了术中的需求检测残留癌症。当前的术中边缘工具评估很耗时，缺乏足够的肿瘤特异性。多种的新兴的光学技术提高了灵敏度和特异性，但仍在遭受了漫长的程序时间。我们提出了一个多模式光谱学光声/超声成像系统以区分癌症和正常组织在切除的乳腺组织中。提供化学含量和机械含量属性信息，该系统名为MarginPat，能够测量地图组织成分，包括血液，脂肪，纤维化组织和乳房病变。基于在紧凑的拉曼激光器和高速扫描室上 MarginPat系统能够扫描每分钟10 CM2组织区域，该区域比一个冷冻部分分析（术中评估的黄金标准）数量级。这样的能力允许3维度评估在整个切除的组织中的状态> 90％的灵敏度和特异性。