Training for Clinician Scientists in Pediatric Critical Cardiopulmonary Disease

儿科危重心肺疾病临床科学家培训

• 批准号: 9212847
• 负责人: Anne M Murphy
• 金额: $ 32.42万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9212847
• 关键词: Childhood; Pulmonary Heart Disease; Scientist; Training

 DESCRIPTION (provided by applicant): Pediatric critical cardiovascular and lung disorders are the leading causes of infant mortality in the United States and other developed nations. In addition, there is significant morbidity and mortality in survivors of congenital heart disease surgery and other infants and children with critical heart and lung disorders including those children with primary myocardial diseases, inherited disorders of connective tissue, pulmonary hypertension, chronic lung disease and cerebrovascular injury secondary to many of these diseases. These facts indicate a compelling need for training pediatric physician-investigators oriented towards critical cardiovascular and lung disease. This proposal describes a multidisciplinary training program to prepare clinician-scientists who are in subspecialty training programs for Pediatric Cardiology, Pediatric Critical Care or Neonatology to be rigorously trained for 2 years in either laboratory or clinical investigation related to pediatric critical cardiovascular and lung disease. The program is supported by faculty who are experts in laboratory, clinical and translational research, including expertise in myocardial and vascular biology, lung and pulmonary vascular disorders, genetics, proteomics and biomarkers, bioinformatics, imaging, device development, clinical trials and clinical implementation and safety research. The environment provides many opportunities for trainees by virtue of superb centers, core facilities and programs in which faculty participate such as an NHLBI Proteomics Center, many clinical trials, the Armstrong Institute for Patient Safety and Quality and a Graduate Training Program in Clinical Investigation. Two potential research tracts are proposed including training for physician scientists (M.D. or M.D., Ph.D.) in A. Laboratory research for physician scientists with an emphasis on translational research. B. Clinical investigation supported by the Graduate Training Program in Clinical Investigation which may include clinical implementation research which is vitally important in critical care fields. Each of 4 trainees in te program will have an individualized program which will be planned in consultation with a Steering Committee, a primary mentor and mentorship team. The proposal incorporates strategies to enhance recruitment of underrepresented minority and ethnic groups with leadership from the director of the Pediatric Department diversity committee, and training in the responsible conduct of research. At the conclusion of the program the trainees will be well prepared to transition towards positions in academic pediatric cardiology and intensive care fields developing funded independent research careers.

 描述（由适用提供）：小儿关键心血管和肺部疾病是美国和其他发达国家婴儿死亡率的主要原因。此外，先天性心脏病手术的生存以及其他患有心脏和肺部疾病的儿童的发病率和死亡率很高，包括那些患有原发性心肌疾病的儿童，结缔组织的遗传疾病，结缔组织，肺部高血压，慢性肺部疾病和脑脑造成这些疾病的疾病。这些事实表明，迫切需要训练针对关键心血管和肺部疾病的小儿物理治疗剂。该提案描述了一项多学科培训计划，以准备接受专业培训的临床科学家 小儿心脏病学，小儿重症监护或新生儿学的计划进行了2年的严格培训，用于与儿科重症心血管和肺部疾病有关的实验室或临床研究。该计划得到了实验室，临床和翻译研究专家的教师的支持，包括心肌和血管生物学专业知识，肺和肺血管疾病，遗传学，蛋白质组学和生物标志物，生物信息组学，图像，图像，设备开发，临床试验以及临床实施以及临床实施和安全研究。该环境为学员提供了许多机会，借助高级中心，核心设施和计划，其中包括NHLBI蛋白质组学中心等教师参与，许多临床试验，阿姆斯特朗患者安全和质量研究所以及临床调查的研究生培训计划。提出了两个潜在的研究区，包括在A. A.物理科学家实验室研究中对医师科学家的培训（M.D.或M.D.），重点是转化研究。 B.临床研究研究生培训计划支持的临床投资，其中可能包括在重症监护领域至关重要的临床实施研究。 TE计划中的4个学员中的每一个都将有一个个性化的计划，该计划将与指导委员会（主要导师和心态团队）协商。该提案纳入了在儿科部门多样性委员会主任的领导下，加强代表性不足的少数群体和种族群体的策略，并在负责任的研究中进行培训。在该计划结束时，学员将做好充分的准备，以朝着学术儿科心脏病学和重症监护领域的职位过渡，开发了资助的独立研究职业。