Training for Clinician Scientists in Pediatric Critical Cardiopulmonary Disease

儿科危重心肺疾病临床科学家培训

• 批准号: 10227659
• 负责人: Anne M Murphy
• 金额: $ 36.57万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10227659
• 关键词: Childhood; Pulmonary Heart Disease; Scientist; Training; Childhood; Pulmonary Heart Disease; Scientist; Training

Pediatric critical cardiovascular and lung disorders are the leading causes of infant mortality in the United States and other developed nations. In addition, there is significant morbidity and mortality in survivors of congenital heart disease surgery and other infants and children with critical heart and lung disorders including those children with primary myocardial diseases, inherited disorders of connective tissue, pulmonary hypertension, chronic lung disease and cerebrovascular injury secondary to many of these diseases. These facts indicate a compelling need for training pediatric physician-investigators oriented towards critical cardiovascular and lung disease. This renewal proposal describes a multidisciplinary training program to prepare clinician-scientists who are in subspecialty training programs for Pediatric Cardiology, Pediatric Critical Care or Neonatology to be rigorously trained for 2 years in either laboratory or clinical investigation related to pediatric critical cardiovascular and lung disease. The program is supported by faculty who are experts in laboratory, clinical and translational research, including expertise in myocardial and vascular biology, lung and pulmonary vascular disorders, genetics, proteomics and biomarkers, computational medicine, imaging, clinical trials and clinical implementation and safety research. The environment provides many opportunities for trainees by virtue of superb centers, core facilities and programs in which faculty participate such as NHLBI supported clinical trials, the Armstrong Institute for Patient Safety and Quality and a Graduate Training Program in Clinical Investigation. Two research tracts are proposed including training for physician scientists (M.D. or M.D., Ph.D.) in A. Laboratory research for physician scientists with an emphasis on translational research. B. Clinical investigation supported by the Graduate Training Program in Clinical Investigation, which may include clinical implementation research which is vitally important in critical care fields. Each of four trainees in the program will have an individual development plan program that is created in consultation with a Steering Committee, a primary mentor and mentorship team. The proposal incorporates strategies to enhance recruitment of underrepresented minority and ethnic groups with leadership from a member of the Pediatric Department diversity committee, and training in the responsible conduct of research. At the conclusion of the program, the trainees will be well prepared to transition towards positions in academic pediatric cardiology and intensive care fields developing funded independent research careers.

小儿关键心血管和肺部疾病是美国婴儿死亡率的主要原因 和其他发达国家。此外，先天性幸存者的发病率和死亡率很高 心脏病手术以及其他婴儿和肺部疾病（包括这些儿童）的儿童 与原发性心肌疾病，结缔组织的遗传疾病，肺动脉高压，慢性肺 疾病和脑血管损伤继发于许多这些疾病。这些事实表明了引人入胜的 需要培训针对关键心血管和肺部病的小儿医师治疗剂。这 续签提案描述了一项多学科培训计划，以准备临床医生 小儿心脏病学，小儿重症监护或新生儿学的专科培训计划 在与儿科关键心血管和肺有关的实验室或临床研究中接受了2年的培训 疾病。该计划得到了实验室，临床和转化研究专家的教师的支持， 包括心肌和血管生物学，肺和肺血管疾病，遗传学， 蛋白质组学和生物标志物，计算医学，成像，临床试验和临床实施以及 安全研究。环境为受训者提供了许多机会，良好的中心，核心 教师参与的设施和计划，例如NHLBI支持临床试验，阿姆斯特朗研究所 用于患者的安全和质量以及临床研究的研究生培训计划。两个研究区 提出了包括医师科学家的培训（M.D.或M.D.，博士学位）。 强调翻译研究的医师科学家。 B.由 临床研究的研究生培训计划，其中可能包括临床实施研究 在重症监护领域至关重要。该计划中的四名学员中的每一个都将有个人发展 与指导委员会协商，主要导师和指导制定的计划计划 团队。该提案纳入了增强代表性不足的少数群体和种族的策略 小组在儿科部门多样性委员会成员的领导下，并接受了培训 负责任的研究。在计划结束时，学员将做好充分的准备过渡 在学术儿科心脏病学和重症监护领域的职位发展。 研究事业。