Alcohol abuse/dependence and its consequences for Indigenous adolescents

酒精滥用/依赖及其对土著青少年的影响

基本信息

批准号：
8501134
负责人：
LESLIE B WHITBECK
金额：
$ 43.55万
依托单位：
UNIVERSITY OF NEBRASKA LINCOLN
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8501134
关键词：
Address Adolescence Adolescent Adolescent Behavior Affect Age Alcohol abuse Alcohol consumption Alcohol dependence Alcohols Attention Basic Science Behavior Behavioral Symptoms Biological Characteristics Communities Comorbidity Complex Conduct Disorder Data Data Analyses Data Collection Data Reporting Data Set Dependence Development Developmental Diagnostic Developmental Process Diagnostic Disease Dysthymic Disorder Educational workshop Family Process Foundations Frequencies Funding Future Generalized Anxiety Disorder Goals Grant Healed Indigenous Intervention Left Measures Mediating Mediator of activation protein Mental disorders National Institute of Drug Abuse National Institute of Mental Health Ojibwe Oppositional Defiant Disorder Outcome Ownership Parents Pathway interactions Population Prevention Prevention program Process Reporter Reporting Research Research Personnel Reservations Risk Running Science Staging State Government Substance Use Disorder Symptoms Time Translating Translations Trust United States National Institutes of Health Work Writing aged alcohol epidemiology alcohol prevention anti social base community based participatory research design early adolescence emerging adult empowered expiration externalizing behavior healing high risk innovation intergenerational meetings programs public health relevance public policy on alcohol response single episode major depressive disorder technical writing underage drinking young adult

项目摘要

DESCRIPTION (provided by applicant): This [is the second submission of our RO1 application] in response to the announcement: Secondary Analysis of Existing Alcohol Epidemiology Data (PA-08-167). With this application we seek funding to extend our community-based participatory research (CBPR) with Ojibwe people on four U.S. reservations and four Canadian reserves for three additional years to work with our community partners to complete data analysis focusing on the development of alcohol abuse and dependence disorders among Ojibwe adolescents. The proposed state-of-the- science longitudinal analyses of a one-of-a-kind eight-year panel study of adolescents (aged 10 - 12 years at Wave 1 and 17 - 19 years at Wave 8) will advance our understanding of developmental processes regarding alcohol use and abuse among a high-risk population, inform innovative, empirically driven, cultural interventions and fulfill the CBPR obligation of leaving something useful behind after more than eight years of community involvement in collecting this important information. The program of research on which this application is based was a lagged sequential design funded by NIDA and NIMH. DA13580 was initially funded 9/30/2000 and renewed via a competitive continuation 9/03/2005. MH067281 was initially funded 7/01/2002 and competitively renewed 7/01/07. The work comprises the only long-term developmental, diagnostic study of Indigenous adolescents and their parents/caretakers to date. Funding for DA13580 runs out 6/30/2010 and with it our ability to maintain our community partnerships. The specific aims of the original research application DA13580 have been accomplished but there remains an enormous amount of analytic work with an extremely rich and complex data set focusing specifically on onset of alcohol use and abuse and its consequences from early to late adolescence. The analytic plan will address eight foci: 1) the emergence of alcohol use, abuse, and dependence across time; 2) the relationship between internalizing and externalizing behaviors on alcohol use and abuse; 3) protective factors against adolescent alcohol use and abuse; 4) the effects of group membership on alcohol outcomes; 5) co morbidities of alcohol abuse/dependence with other psychiatric disorders such as major depressive episode, generalized anxiety disorder, and conduct disorder; 6) the timing of behaviors related to alcohol use in relation to one another, 7) potential mediators between alcohol use and antisocial behaviors; and 8) the effects of community characteristics on alcohol use/abuse. This is the only longitudinal, diagnostic data set of which we are aware that follows Indigenous young people through their entire adolescence. The eight-wave data set has four DISC-R diagnostic data points: Wave 1 (ages 10 - 12 years; parent/caretaker and adolescent reports); Wave 4 (ages 13 - 15 years; parent/caretaker and adolescent reports); Wave 6 (ages 15 - 17 years, adolescent reports); Wave 8 (ages 17 - 19 years, adolescent reports). In addition to four diagnostic data points, the data is replete with symptom and behavioral scales, multiple reporter (parent/caretaker and adolescent) measures of parent/caretaker-adolescent interactions and adolescent behaviors, and community measures. The proposed analyses provide a unique opportunity to trace the early emergence of alcohol use and its developmental consequences, including the onset of alcohol abuse and dependence disorders.

描述（由申请人提供）：这是对公告的回应[这是我们第二次提交 RO1 申请]：现有酒精流行病学数据的二次分析 (PA-08-167)。通过此申请，我们寻求资金来扩展我们在美国四个保留地和加拿大四个保留地的奥及布威人的社区参与性研究 (CBPR)，为期三年，与我们的社区合作伙伴合作，完成数据分析，重点关注酗酒和酗酒的发展情况。奥及布威青少年的依赖障碍。一项针对青少年（第 1 波年龄为 10 - 12 岁，第 8 波年龄为 17 - 19 岁）的一项独一无二的为期 8 年的小组研究提出的最新科学水平纵向分析将增进我们对以下问题的理解：关于高风险人群中酒精使用和滥用的发展过程，为创新、经验驱动的文化干预措施提供信息，并履行 CBPR 的义务，即在社区参与收集这一重要信息八年多之后留下一些有用的东西。本申请所基于的研究计划是由 NIDA 和 NIMH 资助的滞后序贯设计。 DA13580 最初于 2000 年 9 月 30 日获得资助，并于 2005 年 9 月 3 日通过竞争性延续进行更新。 MH067281 最初于 2002 年 7 月 1 日获得资助，并于 2007 年 7 月 1 日竞争更新。这项工作是迄今为止唯一针对土著青少年及其父母/看护者的长期发展诊断研究。 DA13580 的资金将于 2010 年 6 月 30 日用完，我们将有能力维持我们的社区伙伴关系。最初的研究应用 DA13580 的具体目标已经实现，但仍有大量的分析工作需要极其丰富和复杂的数据集，特别关注酒精使用和滥用的发生及其从青春期早期到晚期的后果。该分析计划将解决八个焦点：1）随着时间的推移，酒精使用、滥用和依赖的出现； 2）饮酒和滥用的内化行为和外化行为之间的关系； 3) 防止青少年饮酒和滥用酒精的保护因素； 4) 团体成员身份对酒精结果的影响； 5) 酒精滥用/依赖与其他精神疾病的共病，如重度抑郁发作、广泛性焦虑症和品行障碍； 6) 彼此之间与饮酒相关的行为的时间安排，7) 饮酒与反社会行为之间的潜在中介因素； 8) 社区特征对酒精使用/滥用的影响。据我们所知，这是唯一追踪土著年轻人整个青春期的纵向诊断数据集。八波数据集有四个 DISC-R 诊断数据点：第一波（10 - 12 岁；家长/看护人和青少年报告）；第 4 波（13 - 15 岁；家长/看护人和青少年报告）；第 6 波（15 - 17 岁，青少年报告）；第 8 波（17 - 19 岁，青少年报告）。除了四个诊断数据点之外，该数据还充满了症状和行为量表、父母/看护者与青少年互动和青少年行为的多个报告者（父母/看护者和青少年）测量以及社区测量。拟议的分析提供了一个独特的机会来追踪酒精使用的早期出现及其发展后果，包括酒精滥用和依赖性障碍的发生。