Novel Factors for Muscle Mass and Strength in Adults

影响成人肌肉质量和力量的新因素

• 批准号: 9324114
• 负责人: Shivani Sahni
• 金额: $ 38.55万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9324114
• 关键词: Accounting; Address; Adult; Affect; Age; Aging; American; Amino Acids; Antioxidants; Ascorbic Acid; Blood Vessels; Blood flow; Carnitine; Carotenoids; Characteristics; Coenzymes; Collagen; Communities; DNA copy number; Data; Diet; Elderly; Future; Gait speed; Goals; Hand Strength; Health; Impairment; Individual; Inflammation; Insulin; Intake; Intervention; Intervention Studies; Knowledge; Link; Measures; Mediating; Mitochondria; Mitochondrial DNA; Modeling; Muscle; Muscle Proteins; Muscle function; Muscular Atrophy; Outcome; Oxidative Stress; Participant; Pathway interactions; Perfusion; Physical Function; Physical activity; Physiological; Public Health; Rest; Risk Factors; Role; Skeletal Muscle; Thinness; Time; Upper Extremity; Validation; Vitamin E; Woman; Work; age related; age-related muscle loss; arm; base; brachial artery; cardiovascular health; cohort; combat; disability; fall risk; fracture risk; frailty; insight; men; multi-component intervention; muscle form; muscle strength; novel; offspring; prevent; protein intake; reduced muscle mass; response; time use

ABSTRACT / PROJECT SUMMARY Age-related decline in muscle mass and strength is an important public health issue. Future interventions will depend on identifying the physiologic pathways involved in these muscle changes and consequent physical function. We propose to investigate novel risk factors and identify associated pathways that affect age-related declines in muscle mass, quality, strength and gait speed. Our long term goal is to identify novel risk factors and associated pathways that affect age-related declines in muscle and physical function. The objective is to determine the roles of antioxidant intake, vascular function and mitochondrial function in loss of muscle mass, quality, strength and gait speed in adult men and women, providing new public health insights. We hypothesize that low antioxidant intake, impaired vascular function and lower mitochondrial DNA copy number (mtDNA-CN) will each contribute towards decreased muscle mass, quality, strength and gait speed, even accounting for established risk factors. We will address this work via 4 aims using up to 1,912 participants from a well- characterized cohort, the Framingham Offspring Study. Aim 1 will examine the association of antioxidant intakes (Vitamin C, Vitamin E and total carotenoids) with measures of muscle mass, quality, strength [defined as appendicular lean muscle mass/height2, grip strength-to-arm lean mass ratio (arm muscle quality), change in appendicular lean muscle mass/height2, change in grip strength over time] and change in gait speed. Aim 2 will examine the association of vascular function (assessed by brachial artery resting characteristics, hyperemic flow response and aortic stiffness with measures of muscle mass, quality, strength and change in gait speed. Aim 3 will examine the association of mtDNA-CN with measures of muscle mass, quality, strength and change in gait speed. Finally, Aim 4 will examine the combined effect of the novel risk factors evaluated from Aims 1-3 along with established risk factors (protein intake, physical activity and inflammation), on measures of muscle mass, quality, strength and change in gait speed. We plan to validate the findings from these aims by using a validation cohort, the Cardiovascular Health Study. The expected outcome is evidence for low antioxidant intake, impaired vascular and low mtDNA-CN as novel risk factors for age-related decrease in muscle mass, quality, strength and gait speed. The significance of the proposed work is that it will increase our understanding of individual contributions and combined effect of the proposed novel risk factors on age-related declines in muscle and physical function. This study will provide a strong basis for future multi-modality intervention studies aimed at reducing or preventing age-related declines in muscle and their debilitating consequences among older adults. 1

摘要 /项目摘要 与年龄相关的肌肉质量和力量下降是一个重要的公共卫生问题。未来的干预措施将 取决于识别这些肌肉变化所涉及的生理途径以及随之而来的身体 功能。我们建议研究新的风险因素，并确定影响与年龄有关的相关途径 肌肉质量，质量，力量和步态速度下降。我们的长期目标是确定新颖的风险因素 以及影响年龄相关的肌肉和身体机能下降的相关途径。目的是 确定抗氧化剂摄入，血管功能和线粒体功能在肌肉质量损失中的作用， 成人男女的质量，力量和步态速度，提供新的公共卫生见解。我们假设 低抗氧化剂摄入，血管功能受损和线粒体DNA拷贝数（mtDNA-CN） 每个人都会有助于降低肌肉质量，质量，力量和步态速度，甚至考虑到 已建立的风险因素。我们将通过4个目标来解决这项工作 弗雷明汉（Framingham）后代研究（Framingham后代研究）的特征是。 AIM 1将检查抗氧化剂的关联 摄入量（维生素C，维生素E和总类胡萝卜素），肌肉质量，质量，强度[定义 作为阑尾瘦肌肉质量/高度2，抓地力与臂瘦质量比（手臂肌肉质量），更改 在阑尾瘦肌肉/高度2中，随着时间的推移，握力强度的变化和步态速度的变化。目标2 将检查血管功能的关联（通过肱动脉静止特征评估， 高血流动反应和主动脉僵硬，肌肉质量，质量，强度和变化 步态速度。 AIM 3将检查mtDNA-CN与肌肉质量，质量，强度的措施的关联 和步态速度的变化。最后，AIM 4将检查评估的新型风险因素的综合效果 从目标1-3以及既定的危险因素（蛋白质摄入，体育锻炼和炎症）中， 肌肉质量，质量，力量和步态速度变化的度量。我们计划从 这些目的是使用验证队列，即心血管健康研究。 预期结果是抗氧化剂摄入量低，血管和低mtDNA-CN作为新颖的证据 与年龄相关的肌肉质量，质量，力量和步态速度的降低风险因素。意义的意义 拟议的工作是，它将增加我们对个人贡献的理解和综合影响 拟议的新型风险因素对年龄相关的肌肉和身体机能下降。这项研究将提供 旨在减少或预防与年龄相关的下降的未来多模式干预研究的强大基础 在肌肉及其老年人的衰弱后果中。 1