Integrating social networks through amygdalostriatal paths

通过杏仁核纹状体路径整合社交网络

• 批准号: 9275017
• 负责人: JULIE L. FUDGE
• 金额: $ 36.44万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-16 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9275017
• 关键词: Amygdaloid structure; Anatomy; Animals; Anxiety; Area; Autistic Disorder; Basal Ganglia; Brain; Brain region; Cell Nucleus; Cells; Cognitive; Confocal Microscopy; Corpus striatum structure; Cues; Detection; Emotional; Emotions; Fiber; Human; Injection of therapeutic agent; Insula of Reil; Label; Laboratories; Light Microscope; Maps; Mediating; Mental disorders; Microscopic; Monitor; Neurons; Organizational Productivity; Output; Pathway interactions; Patients; Physiological; Play; Population; Positioning Attribute; Prefrontal Cortex; Primates; Psychotic Disorders; Role; Social Concepts; Social Functioning; Social Network; Structure; Synapses; Syndrome; Tracer; Undifferentiated; Ventral Striatum; emotion dysregulation; motivated behavior; neuroimaging; nonhuman primate; novel; public health relevance; putamen; relating to nervous system; segregation; severe mental illness; social; symptomatology

DESCRIPTION (provided by applicant): Integrating social networks through amygdalostriatal paths A longstanding focus of our laboratory is the identification of pathways through the primate amygdala that are positioned to mediate symptomatology of severe mental illnesses. Because emotional dysregulation in psychiatric syndromes is often expressed as maladaptive social function, the proposed studies examine how networks involved in social function interact with 'salience detection' pathways in the amygdala and striatum of the nonhuman primate. Tract tracing studies in nonhuman primate enable more accurate interpretation of neuroimaging results in humans, and are a critical bridge for understanding details of primate brain structure on a cellular level. In this set of studies, we examine two cortical networks that are frequently dysregulated in psychiatric illnesses: the 'salience detection' network (areas 25/32, agranular insula) which monitors internal physiologic states to 'mark' salient cues, and the 'social monitoring' network (areas 24/14/dysgranular cortex), which detects and interprets the meaning and value of others' actions. These networks are often considered physiologically distinct. However, since emotional dysregulation in human illness is frequently expressed in misinterpretation of social cues, integration of 'salience' and 'social monitoring' networks must exist. We propose that specific circuits through the amygdala and striatum are substrates for this integration. Aim 1 will map the boundaries of inputs from 'social-monitoring-associated' cortex in the amygdala, and the resulting organization of outputs to the striatum. In Aim 2, we will place retrograde tracers into novel striatal sectors targeted by 'social' corticoamygdala-striatal path in Aim 1 to determine whether they are defined by direct cortical projections from the social monitoring network. In Aim 3 we will examine the amygdala under higher power, to determine whether converging inputs terminals from nodes of the 'salience' and 'social monitoring' networks predominantly synapse on the same neural population, or on separate subpopulations.

描述（由申请人提供）：通过杏仁核路径整合社交网络，我们实验室长期以来的重点是通过灵长类动物杏仁核的识别，这些途径可以介导严重精神疾病的症状。由于精神综合症中的情绪失调通常被表示为适应不良的社会功能，因此拟议的研究研究了社会功能中涉及的网络如何与非人类灵长类动物的杏仁核和纹状体中的“显着性检测”途径相互作用。在非人类灵长类动物中进行的研究研究可以更准确地解释人类的神经影像学结果，并且是了解细胞水平上灵长类动物大脑结构细节的关键桥梁。 In this set of studies, we examine two cortical networks that are frequently dysregulated in psychiatric illnesses: the 'salience detection' network (areas 25/32, agranular insula) which monitors internal physiologic states to 'mark' salient cues, and the 'social monitoring' network (areas 24/14/dysgranular cortex), which detects and interprets the meaning and value of others' actions.这些网络通常在生理上被认为是不同的。但是，由于人类疾病中的情绪失调经常在误解社会线索中表达，因此必须存在“显着性”和“社会监测”网络的整合。我们建议通过杏仁核和纹状体的特定电路是这种整合的底物。 AIM 1将绘制杏仁核中“社会监测相关”皮层的投入界限，以及最终的输出组织到纹状体。在AIM 2中，我们将将逆行示踪剂置于目标1的“社会”皮质洋性纹状体路径目标1中，以确定它们是否由社会监测网络的直接皮质预测定义。在AIM 3中，我们将在更高的力量下检查杏仁核，以确定来自“显着性”和“社会监测”网络的融合输入终端是主要在同一神经群体上突触还是在单独的亚群上进行突触。