Striatum/Amygdalostriatal Area

纹状体/杏仁纹状体区

• 批准号: 6539242
• 负责人: JULIE L. FUDGE
• 金额: $ 23.93万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6539242
• 关键词: Macaca nemestrina; acetylcholinesterase; amygdala; behavioral /social science research tag; corpus striatum; dopamine receptor; electrophysiology; emotions; enkephalins; human tissue; immunocytochemistry; in situ hybridization; neural information processing; neural transmission; neuroanatomy; neurochemistry; psychosis; radionuclide double label; sound perception; substance P; temporal lobe /cortex; tyrosine 3 monooxygenase

DESCRIPTION: (Applicant's abstract) The ventral ('limbic-related) striatum mediates motivated behavior, and is considered an important anatomic Substrate of psychosis. The amygdala, a prominent limbic structure, links complex sensory stimuli to their emotional significance. One way the ventral striatum can be defined is based on inputs from structuresthat mediate emotional processing the amygdala; orbitomedial prefrontal regions linked to the amygdala, and the dorsal tier dopamine (DA) neurons. The ventral striatal 'shell' is a unique subregion that receives restricted inputs from these structures, and is charactenzed by 1. Relatively low calbindin-Dk28 (CaBP) staining, 2. Multiple cellular ('interface') islands with differential distributions of substance F, enkephalin, acetyicholinesterase (AchE), tyrosine hydroxylase (TH), and D1 mRNA, 3. Regions of precise overlap between amygdaloid afferents and cell clusters associated with specific transmitters, 4. Regions of tight overlap between amygdaloid and cortical afferents. We hypothesize that the caudoventral striatum and adjacent amygdalostriatal area (Astr) is a special part of the ventral 'limbic' striatum that is devoted to temporal lobe inputs, based on similar criteria. The temporal lobes mediate auditory and visual processing, are interconnected with the amygdala, and are a site of abnormalities in schizophrenia. Our preliminary data suggest that, like the ventral striatum, the caudoventral striatum/Astr area: 1. Receives afferents from brain structures mediating emotion: amygdala, specific regions of cortex linked to the amygdala, and the DA neurons. 2. Receives input from a caudal component of the 'dorsal tier' of DA neurons 3. Has a CaBP-poor region, and multiple cellular islands associated with varying distributions of substance F, enkephalin, AchE, TH, and D1 mRNA, similar to that found in the shell. The first goal of these studies is to determine whether the caudoventral striatum/Astr area is part of the ventral striatum based on connectional, cytoarchitectural, and histochemical features. Our second aim is to examine the hypothesis that the amygdala projects to cellular clusters containing substance P and Dl receptor mRNA in the caudoventral striatal/Astr area, and is therfore in a position to activate these transmitter/receptor specific pathways. Our third aim is to determine whether amygdaloid and temporal cortical inputs converge in the caudoventral striatum/Astr area. The results of these studies will provide an anatomic framework for understanding how emotionally significant auditory and visual information is processed in the striatum.

描述：（申请人的摘要）腹侧（与边缘相关的）纹状体 介导动机行为，被认为是重要的解剖基板 精神病。杏仁核，一种突出的边缘结构，将复杂的感觉联系起来 刺激其情感意义。腹侧纹状体的一种方式是 定义的是基于结构图中介导情感处理的输入 杏仁核；与杏仁核有关的轨道前额叶区域 背层多巴胺（DA）神经元。腹侧纹状体“外壳”是独特的 从这些结构中获得限制输入的子区域，IS 用1。相对较低的Calbindin-DK28（CABP）染色，2。 具有物质F差分分布的细胞（“界面”）岛 Enkephalin，乙酸乙烯酸酯酶（ACHE），酪氨酸羟化酶（Th）和D1 mRNA，3。杏仁核和细胞之间精确重叠的区域 与特定发射器相关的簇，4。紧密重叠的区域 在杏仁核和皮质传入之间。 我们假设Caudoventral纹状体和相邻的杏仁核纹状体 区域（Astr）是专门的腹侧“边缘”纹状体的特殊部分 基于类似标准到颞叶输入。颞叶介导 听觉和视觉处理，与杏仁核相互连接，是一个 精神分裂症异常部位。我们的初步数据表明， 腹侧纹状体，尾腹纹状体/ASTR区域：1。 大脑结构的传入介导情感：杏仁核，特定区域 与杏仁核和DA神经元相关的皮质的。 2。从一个 DA神经元3的“背侧层”的尾部成分。 以及与各种分布相关的多个蜂窝岛 物质F，Enkephalin，Ache，Th和D1 mRNA，类似于在 壳。 这些研究的第一个目标是确定caudoventral是否 纹状体/ASTR区域是基于连接的腹侧纹状体的一部分， 细胞结构和组织化学特征。我们的第二个目标是检查 假设杏仁核投射到含有物质的细胞簇 caudoventral纹状体/ASTR区域的P和DL受体mRNA，因此 可以激活这些发射机/受体特定途径。我们的 第三个目的是确定杏仁核和颞皮质输入是否 在尾腹纹状体/ASTR区域收敛。这些研究的结果 将提供一个解剖框架，以了解情感如何 在纹状体中处理了重要的听觉和视觉信息。