Mentoring Clinical Researchers at the Intersection of NeuroAIDS and Substance Abuse

指导神经艾滋病和药物滥用交叉点的临床研究人员

基本信息

批准号：
9303333
负责人：
MARIANA CHERNER
金额：
$ 16.15万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9303333
关键词：
Acquired Immunodeficiency Syndrome Affect Alcohol consumption Alcohol or Other Drugs use Alcohols Anti-Inflammatory Agents Anti-inflammatory Area Award Biological Markers Brain CYP2D6 gene California Cannabis Clinical Code Competence Complex Data Development Diabetes Mellitus Doctor of Philosophy Dopamine Environment Faculty Fellowship Funding Funding Opportunities Genetic Polymorphism Genetic Predisposition to Disease Genetic Risk Goals Grant HIV HIV-associated neurocognitive disorder Hispanics Individual Differences Inflammation Interdisciplinary Study Knowledge Latino Marijuana Mediating Medicine Mentors Metabolic Metabolic syndrome Metabolism Methamphetamine Methods Mexican Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Native Americans Nervous system structure Neurocognition Neurocognitive Neuropsychology Outcome Performance Population Heterogeneity Postdoctoral Fellow Prevalence Psychiatry Publications Publishing Research Research Ethics Research Methodology Research Personnel Resources Risk Role Science Scientist Serotonin Subgroup Substance abuse problem Testing Training United States National Institutes of Health Universities Variant Woman Work addiction brain dysfunction career doctoral student early experience experience genetic variant graduate student health disparity immune activation interest lifestyle factors lipid metabolism marijuana use methamphetamine effect methamphetamine use methamphetamine user mid-career faculty neuroAIDS neurobehavioral neuroinflammation neuropsychiatry patient oriented polysubstance abuse professor programs public health relevance undergraduate student

项目摘要

DESCRIPTION (provided by applicant): Mariana Cherner, PhD, is an Associate Professor of Psychiatry at the University of California San Diego and an NIH-funded neuroAIDS investigator for over 15 years. This is a proposal for a K24 Midcareer Investigator Award in Patient-Oriented Research to increase Dr. Cherner's ability to mentor clinician scientists and bring them into the fold of research at the intersection of neuroAIDS and substance abuse. Dr. Cherner has mentored more than 30 trainees at various career stages, from undergraduates to junior faculty. Greater than half of her mentees have been from underrepresented backgrounds, and a majority are women. With support from the proposed K24 award, Dr. Cherner would be able to expand her mentoring efforts and maintain a special focus on attracting trainees from backgrounds that are not well-represented in academic medicine. During the proposed award, Dr. Cherner plans to provide mentoring in her current areas of research, broadly (1) individual differences in vulnerability to methamphetamine-related brain dysfunction in the context of HIV, and (2) cross-cultural applications of neuropsychological methods to detect effects of HIV and substance abuse in diverse populations. This work will be supported by her own funded grants as well as by her participation in large projects within the HIV Neurobehavioral Research Program (HNRP) at UCSD, which include all the major neuro-oriented HIV studies at UCSD such as the Translational Methamphetamine AIDS Research Center (TMARC), the HIV Neurobehavioral Research Center (HNRC), a T32 grant for Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN), and the R25 Interdisciplinary Research Fellowship in NeuroAIDS, which she directs. This superb "team-science" research environment, along with resources from the Psychiatry Department and the larger UCSD campus, affords excellent opportunities to attract highly qualified trainees and provide rich training experiences for early career patient-oriented researcher. Support from the K24 award would enable Dr. Cherner to reduce administrative and clinical duties to focus the majority of her effort on research mentoring and furthering her research program.

描述（由申请人提供）：Mariana Cherner 博士是加州大学圣地亚哥分校精神病学副教授，也是 NIH 资助的神经艾滋病研究人员超过 15 年。这是一项 K24 职业中期研究人员奖的提案。旨在提高 Cherner 博士指导临床科学家并将他们带入神经艾滋病和药物滥用交叉领域研究的能力的定向研究 Cherner 博士指导了多名专家。 30 名处于不同职业阶段的学员，从本科生到初级教师，超过一半的学员来自代表性不足的背景，其中大多数是女性。在拟议的 K24 奖项的支持下，Cherner 博士将能够扩大她的指导工作。并特别注重吸引来自学术医学领域不具有代表性的背景的学员。在拟议的奖项期间，Cherner 博士计划在她当前的研究领域提供指导，广泛地（1）个体差异。（2）神经心理学方法的跨文化应用，以检测艾滋病毒和药物滥用对不同人群的影响。这项工作将得到她自己资助的资助和资助。她参与了加州大学圣地亚哥分校艾滋病毒神经行为研究计划 (HNRP) 的大型项目，其中包括加州大学圣地亚哥分校所有主要的神经导向艾滋病毒研究，例如转化甲基苯丙胺艾滋病研究中心 (TMARC)、艾滋病毒神经行为研究中心 (HNRC)、跨学科神经艾滋病成瘾研究培训 (TRAIN) 的 T32 资助以及由她领导的 R25 神经艾滋病跨学科研究奖学金，以及来自她领导的卓越的“团队科学”研究环境。精神病学系和更大的加州大学圣地亚哥分校校园提供了绝佳的机会来吸引高素质的实习生，并为早期职业以患者为导向的研究人员提供丰富的培训经验，K24 奖的支持将使 Dr. Cherner 减少了行政和临床职责，将大部分精力集中在研究指导和推进她的研究计划上。