Mechanisms supporting prioritized memory for self-relevant and emotional information with age

随着年龄的增长，支持对自我相关和情感信息进行优先记忆的机制

• 批准号: 9297444
• 负责人: ANGELA GUTCHESS
• 金额: $ 13.28万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9297444
• 关键词: Address; Adult; Affect; Age; Aging; Alzheimer' s Disease; Area; Arousal; Attention; Behavioral; Biological Preservation; Boston; Clinic; Cognitive; Cognitive aging; Collaborations; Elderly; Electrophysiology (science); Emotional; Emotions; Episodic memory; Equation; Event-Related Potentials; Functional Magnetic Resonance Imaging; Functional disorder; Future; Healthcare Systems; Impairment; Individual; Lateral; Lead; Learning; Light; Literature; Longevity; Measures; Medial; Memory; Memory Disorders; Memory Loss; Memory impairment; Modeling; Neurologist; Patients; Performance; Population; Prefrontal Cortex; Process; Psychologist; Recruitment Activity; Research; Research Personnel; System; Temporal Lobe; Testing; Translating; Universities; age effect; age related; amnestic mild cognitive impairment; college; experience; frontal lobe; imaging modality; improved; insight; memory encoding; multilevel analysis; neural circuit; neuromechanism; practical application; sustained attention; young adult

Project Summary Although advancing age affects the ability to encode information effectively, older adults remain able to remember emotionally arousing information and self-referential information better than other types of information. To date, the literatures on emotional memory and self-referential memory have proceeded independently, with little discussion of whether there are overlapping mechanisms that support the relatively preserved memory enhancements associated with these two domains in aging. The proposed research brings together two cognitive aging researchers with expertise in self- referential processing (Angela Gutchess) and emotional processing (Elizabeth Kensinger) and a quantitative psychologist with expertise in structural equation modeling and multi-level modeling (Ehri Ryu). The proposed research uses behavioral, event- related potential, and functional magnetic resonance imaging methods to test two main hypotheses. First, that there is a shared set of cognitive and neural mechanisms engaged for the encoding of self-referential information and emotional information, and that this set of shared processes is relatively preserved with aging (Aim 1). Second, that individuals with amnestic mild cognitive impairment (aMCI) continue to show memory benefits from emotional and self-referential material, and that these benefits are correlated (Aim 2). Research for this aim will be conducted in collaboration with Andrew Budson, an expert in aMCI and Alzheimer's disease. By bringing together two domains of cognitive aging research that have traditionally proceeded independently, the proposed research is likely to shed new light on socioemotional processing and memory systems across the adult lifespan. Moreover, by focusing on areas of relatively preserved memory function among older adults, the proposed research has the potential to elucidate the types of mechanisms that can be harnessed to maximally improve memory performance across the adult lifespan, including among those with aMCI.

项目摘要 尽管增长年龄会影响有效编码信息的能力，但老年人 仍然能够记住情感上引起的信息和自我指出 信息比其他类型的信息更好。迄今为止，关于情感的文献 记忆和自指记忆已经独立进行，很少 讨论是否有重叠的机制相对支持 与这两个域相关的保留记忆增强。这 拟议的研究汇集了两名具有自我专业知识的认知衰老研究人员 参考处理（Angela gutchess）和情感处理（伊丽莎白 Kensinger）和具有结构方程建模专业知识的定量心理学家 和多层建模（Ehri Ryu）。拟议的研究使用行为，事件 - 相关电位和功能磁共振成像方法测试两个主要的 假设。首先，有一组共享的认知和神经机制 参与编码自指的信息和情感信息，以及 这组共享过程相对保存在衰老中（AIM 1）。第二，那 敏感轻度认知障碍（AMCI）的人继续显示记忆 受益于情感和自我指指的材料，这些好处是 相关（目标2）。该目标的研究将与安德鲁合作进行 Budson，AMCI和阿尔茨海默氏病的专家。通过汇集两个域 传统上独立进行的认知衰老研究， 拟议的研究可能会为社会情感处理和记忆提供新的启示 整个成人寿命的系统。此外，通过专注于相对的领域 在老年人中保留的记忆功能，拟议的研究具有潜力 阐明可以利用的机制类型 成人寿命的记忆表现，包括AMCI的人。