Limited Competition of the MAPP Research Network Data Coordinating Core (U01)

MAPP 研究网络数据协调核心（U01）的有限竞争

基本信息

批准号：
8633276
负责人：
J Richard Landis
金额：
$ 349.94万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-15 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8633276
关键词：
Address Ancillary Study Basic Science Biological Markers Biometry Chronic Fatigue Syndrome Chronic Prostatitis Clinical Clinical Data Clinical Research Clinical Sciences Collaborations Collection Communication Consent Forms Data Data Analyses Data Collection Data Quality Data Reporting Database Management Systems Development Ensure Epidemiologic Studies Fibromyalgia Fostering Goals Interstitial Cystitis Investigation Irritable Bowel Syndrome Leadership Logistics Maintenance Manuscripts Molecular Monitor National Institute of Diabetes and Digestive and Kidney Diseases Online Systems Outcome Measure Pattern Pelvic Pain Pennsylvania Phase Phase II Clinical Trials Preparation Procedures Process Protocols documentation Reporting Research Research Design Research Infrastructure Research Personnel Research Project Grants Risk Factors Schedule Science Secure Series Services Site Specimen Subgroup Symptoms Syndrome System Technology Teleconferences Tissues Training Translational Research Universities Update Urology Work Writing base biobank chronic pain chronic pelvic pain clinical epidemiology computerized data exchange data management design experience medical schools meetings multidisciplinary neuroimaging operation planetary Atmosphere programs protocol development public health relevance quality assurance research study tool urologic web site working group

项目摘要

1 This is an application from the Center for Clinical Epidemiology and Biostatistics (CCEB) at the 2 University of Pennsylvania Perelman School of Medicine to continue to serve as the Data 3 Coordinating Core (DCC) for the Multi-disciplinary Approach to the Study of Chronic Pelvic Pain 4 (MAPP) Research Network. This proposal brings together a highly experienced DCC team, 5 currently supporting the NIDDK's MAPP Research Network (http://www.mappnetwork.org), 6 including urology co-investigators with extensive expertise in chronic pelvic pain, chronic 7 prostatitis, and interstitial cystitis. The DCC will continue to provide biostatistical study design 8 and analysis support, comprehensive data management and research computing services for 9 ongoing and new protocols, selected Discovery Site projects, and close collaboration with the 10 Tissue Analysis & Technology Core (TATC). The specific aims of the DCC are to 1) provide 11 scientific leadership and coordination in the design and implementation of inter-disciplinary 12 research projects across the MAPP Research Network~ 2) provide biostatistical expertise in 13 research designs, outcome measures and analytical strategies for clinical and translational 14 research investigations of urologic chronic pelvic pain syndromes (UCPPS)~ 3) provide 15 comprehensive DCC administrative support for the MAPP Research Network, promoting effective 16 communications, coordinating teleconferences, meetings, working groups, and document 17 development and management~ 4) collaborate with the Tissue Analysis and Technology Core 18 (TATC) on best practices for data collection, specimen tracking and storage, as well as to 19 support technical processes between the DCC and TATC~ 5) promote network-wide quality 20 assurance standards, practices and tools, including a comprehensive, secure www-based data 21 management system (DMS) for collection and centralized storage of all multi-site study data~ 6) 22 support the MAPP Research Network Ancillary Projects, assisting in their design, as well as 23 implementing a process for the submission, review and development of ancillary studies~ 7) 24 establish a new MAPP Network Integrated Basic/Translational Science Working Group to develop 25 collaborative basic cellular and molecular scientific studies of UCPPS that are ancillary to current 26 network protocols and complementary to the network's overall study goals. The DCC will 27 continue to leverage their considerable biostatistical and scientific expertise, coordinating and 28 project leadership, as well as urological expertise, to promote DCC best practices for the ongoing 29 conduct of clinical and translational science research projects, and design and planning for MAPP 30 Phase II protocols within the MAPP Research Network.

1 这是来自临床流行病学和生物统计中心 (CCEB) 的申请 2 宾夕法尼亚大学佩雷尔曼医学院继续担任数据 3 慢性盆腔疼痛研究多学科方法的协调核心 (DCC) 4 (MAPP) 研究网络。该提案汇集了经验丰富的 DCC 团队， 5 目前支持 NIDDK 的 MAPP 研究网络 (http://www.mappnetwork.org)， 6 包括泌尿科共同研究者，他们在慢性盆腔疼痛、慢性 7前列腺炎、间质性膀胱炎。 DCC将继续提供生物统计研究设计 8、分析支持、全面的数据管理和研究计算服务 9 个正在进行的和新的协议、选定的 Discovery Site 项目以及与 10 组织分析和技术核心 (TATC)。 DCC 的具体目标是 1) 提供 11 跨学科设计和实施的科学领导和协调 MAPP 研究网络的 12 个研究项目~ 2) 提供以下方面的生物统计专业知识 13 项临床和转化研究设计、结果衡量和分析策略 14 项泌尿科慢性盆腔疼痛综合征 (UCPPS) 研究调查~ 3) 提供 15 DCC 为 MAPP 研究网络提供全面的行政支持，促进有效 16 次沟通、协调电话会议、会议、工作组和文件 17 开发与管理~ 4) 与组织分析与技术核心合作 18 (TATC) 关于数据收集、样本跟踪和存储的最佳实践，以及 19 支持DCC和TATC之间的技术流程~ 5) 提升全网质量 20 个保证标准、实践和工具，包括全面、安全的基于 www 的数据 21 管理系统（DMS），用于收集和集中存储所有多站点研究数据~ 6) 22 支持 MAPP 研究网络辅助项目，协助其设计，以及 23 实施辅助研究的提交、审查和开发流程~ 7) 24 建立新的 MAPP 网络综合基础/转化科学工作组来开发 25 项 UCPPS 协作基础细胞和分子科学研究是当前研究的辅助 26 个网络协议并补充网络的总体研究目标。 DCC 将 27 继续利用其丰富的生物统计和科学专业知识，协调和 28 个项目领导力以及泌尿科专业知识，以促进 DCC 的最佳实践 29 开展临床和转化科学研究项目，以及MAPP的设计和规划 MAPP 研究网络内的 30 个第二阶段协议。