Limited Competition for Continuation of the MAPP-RN DCC

继续 MAPP-RN DCC 的有限竞争

• 批准号: 10464136
• 负责人: J Richard Landis
• 金额: $ 50万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-09 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10464136
• 关键词: Administrative Supplement; Algorithms; Biological Markers; Biological Specimen Banks; Budgets; Case Report Form; Case Study; Clinical; Clinical Data; Cluster Analysis; Cohort Studies; Collaborations; Colorado; Consensus; Data; Deposition; Documentation; Educational Materials; Educational workshop; Engineering; Epidemiology; Funding; General Population; Grant; Investigation; Link; Longitudinal Studies; MRI Scans; Magnetic Resonance Imaging; Measures; Metadata; Methods; National Institute of Diabetes and Digestive and Kidney Diseases; Online Systems; Outcome; Patients; Pattern; Pelvic Pain; Pennsylvania; Phase; Phenotype; Preparation; Procedures; Process; Research; Research Design; Research Personnel; Resources; Schedule; Services; Severities; Specimen; Subgroup; Symptoms; Universities; Visit; chronic pelvic pain; comparative; data curation; data dictionary; data harmonization; data repository; data resource; data visualization; design; improved; interdisciplinary approach; interest; longitudinal analysis; medical schools; neuroimaging; programs; prototype; repository; response; urinary; web site

Project Summary This proposal for an Administrative Supplement to the U24 grant for the Continuation of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Data Coordinating Core (DCC) is being submitted by the DCC for the MAPP Research Network (MAPP-RN) at the University of Pennsylvania Perelman School of Medicine. The DCC team will provide additional services beyond those currently funded as the DCC for the MAPP Research Network, in support of new Specific Aims 1-5 during the current budget year 14 (BY14). The clinical data, documentation and descriptions of the biospecimen resources from the MAPP I EPS and MAPP II SPS will be made accessible for “public facing” exploration via a re-engineered MAPP website (Specific Aim 1), together with a totally new MAPP DataView toolkit (Specific Aim 3) designed for data visualization and for the conduct of comparative analyses between, and within, the extensive EPS and SPS cohort data, as well as to conduct advanced analyses within selected subgroups assembled by aggregating aligned data across both of these two cohort studies. In addition to implementing final data curation and harmonization across the EPS and SPS cohort data, the DCC will prepare extensive documentation for simultaneous posting on the new MAPP website and for deposit to the NIDDK Repository (Specific Aim 2). Furthermore, the DCC will prepare workshop materials and host MAPP DataView workshops, promoting MAPP data use for new research investigations (Specific Aim 4). Educational materials designed for investigators and research teams to maximize the utility of these data resources and to implement specialized statistical procedures (consensus clustering for baseline subgroup discovery, quantifying clinically meaningful change utilizing Global Response Assessment (GRA) scores and levels of symptom change, longitudinal functional clustering for outcome subgroup discovery) applied to MAPP II SPS data will be emphasized. In particular, the DCC will prepare longitudinal analyses using the Global Response Assessment (GRA), Pelvic Pain Severity (PPS) and Urinary Symptoms Severity (USS) profiles available within the MAPP II SPS to identify factors associated with simultaneous improvement in both PPS and USS symptom profiles, in contrast to patients that improve only in PPS, only in USS, or in neither of PPS or USS (Specific Aim 5).

项目概要 本提案为 U24 补助金提供行政补充，以继续 慢性盆腔疼痛 (MAPP) 研究网络数据的多学科方法研究 协调核心 (DCC) 正在由 DCC 提交给 MAPP 研究网络 (MAPP-RN)，网址为 宾夕法尼亚大学佩雷​​尔曼医学院 DCC 团队将提供额外的帮助。 超出目前为 MAPP 研究网络提供 DCC 资助的服务，以支持新的 当前预算年 14 (BY14) 的具体目标 1-5 临床数据、文件和 MAPP I EPS 和 MAPP II SPS 中生物样本资源的描述将可供访问 通过重新设计的 MAPP 网站（具体目标 1）以及全新的 MAPP 进行“面向公众”的探索 MAPP DataView 工具包（具体目标 3）专为数据可视化和进行比较而设计 在广泛的 EPS 和 SPS 队列数据之间和内部进行分析，并进行高级 通过汇总这两个组中的对齐数据来组装选定的子组内的分析 除了在 EPS 和 SPS 中实施最终数据管理和协调之外。 队列数据，DCC 将准备大量文档，以便同时发布在新的 MAPP 上 网站并存入 NIDDK 存​​储库（具体目标 2） 此外，DCC 将做好准备。 研讨会材料并举办 MAPP DataView 研讨会，促进 MAPP 数据用于新研究 调查（具体目标 4）。为调查人员和研究团队设计的教育材料。 最大限度地利用这些数据资源并实施专门的统计程序 （基线亚组发现的共识聚类，利用 总体反应评估 (GRA) 分数和症状变化水平、纵向功能 将强调应用于 MAPP II SPS 数据的结果亚组发现的聚类。 特别是，DCC 将使用全球反应评估 (GRA)、骨盆 MAPP II SPS 中提供疼痛严重程度 (PPS) 和泌尿系统症状严重程度 (USS) 概况，以 相比之下，确定与 PPS 和 USS 症状特征同时改善相关的因素 仅 PPS 改善、仅 USS 改善或 PPS 或 USS 均无改善的患者（具体目标 5）。

项目成果

Brain signature and functional impact of centralized pain: a multidisciplinary approach to the study of chronic pelvic pain (MAPP) network study.

集中疼痛的大脑特征和功能影响：慢性盆腔疼痛（MAPP）网络研究的多学科方法。

• 发表时间: 2017-10
• 影响因子: 7.4
• 作者: Kutch, Jason J;Ichesco, Eric;Hampson, Johnson P;Labus, Jennifer S;Farmer, Melissa A;Martucci, Katherine T;Ness, Timothy J;Deutsch, Georg;Apkarian, A Vania;Mackey, Sean C;Klumpp, David J;Schaeffer, Anthony J;Rodriguez, Larissa V;Kreder, Karl J
• 通讯作者: Kreder, Karl J

Quantitative assessment of nonpelvic pressure pain sensitivity in urologic chronic pelvic pain syndrome: a MAPP Research Network study.

泌尿科慢性盆腔疼痛综合征中非盆腔压力疼痛敏感性的定量评估：MAPP 研究网络研究。

• 发表时间: 2019
• 影响因子: 7.4
• 作者: Harte, Steven E;Schrepf, Andrew;Gallop, Robert;Kruger, Grant H;Lai, Hing Hung Henry;Sutcliffe, Siobhan;Halvorson, Megan;Ichesco, Eric;Naliboff, Bruce D;Afari, Niloofar;Harris, Richard E;Farrar, John T;Tu, Frank;Landis, John Richard;Clauw, Da
• 通讯作者: Clauw, Da

Correlates of 1-Year Change in Quality of Life in Patients with Urologic Chronic Pelvic Pain Syndrome: Findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network.

泌尿科慢性盆腔疼痛综合征患者生活质量一年变化的相关性：慢性盆腔疼痛 (MAPP) 研究网络多学科方法的研究结果。

• 发表时间: 2020
• 作者: Clemens, J Q;Stephens;Newcomb, C;Rodriguez, L V;Lai, H H;Bradley, C S;Naliboff, B D;Griffith, J W;Taple, B J;Gupta, P;Afari, N;Harte, S E;Strachan, E;Guo, W;Landis, J R
• 通讯作者: Landis, J R

Longitudinal Changes in the Pelvic Pain Only and Widespread Pain Phenotypes Over One Year in the MAPP-I Urologic Chronic Pelvic Pain Syndrome (UCPPS) Cohort.

MAPP-I 泌尿科慢性盆腔疼痛综合征 (UCPPS) 队列一年内仅盆腔疼痛和广泛疼痛表型的纵向变化。

• 发表时间: 2022-03
• 影响因子: 2.1
• 作者: Lai, Henry;Bayman, Emine O;Bishop, Michael O;Landis, Richard;Harte, Steven E;Clemens, Quentin;Rodriguez, Larissa V;Sutcliffe, Siobhan;Taple, Bayley J;Naliboff, Bruce D;MAPP Research Network
• 通讯作者: MAPP Research Network

Widespread Psychosocial Difficulties in Men and Women With Urologic Chronic Pelvic Pain Syndromes: Case-control Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network.

泌尿科慢性盆腔疼痛综合征男性和女性普遍存在的社会心理困难：慢性盆腔疼痛研究网络多学科方法的病例对照结果。

• DOI: 10.1016/j.urology.2015.02.047
• 发表时间: 2015-06
• 期刊: Urology
• 影响因子: 2.1
• 作者: Naliboff BD;Stephens AJ;Afari N;Lai H;Krieger JN;Hong B;Lutgendorf S;Strachan E;Williams D;MAPP Research Network
• 通讯作者: MAPP Research Network