Study of Latinos (SOL) Ojos

拉丁裔研究 (SOL) 奥霍斯

基本信息

批准号：
10471195
负责人：
CHARLOTTE E JOSLIN
金额：
$ 231.96万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10471195
关键词：
Acculturation Address Admixture Adult African American African ancestry Age Age related macular degeneration American Ancillary Study Aphorisms Asthma Basic Science Biological Blindness Blood Pressure Body mass index C-reactive protein Cardiovascular Diseases Cardiovascular system Caribbean region Cataract Censuses Central American Characteristics Chicago Chinese American Chronic Chronic Obstructive Pulmonary Disease Clinical Research Cohort Studies Communities Community Surveys Contact Lenses Contracts Cuban Data Data Collection Dental caries Detection Diabetes Mellitus Diabetic Retinopathy Disabled Persons Disease Dominican Elderly Epidemiology Ethnic group Etiology European Eye Eye diseases Funding Future Genetic Genotype Glaucoma Glycosylated Hemoglobin Glycosylated hemoglobin A Heterogeneity Hispanic Hispanic Community Health Study/Study of Latinos Hispanic Populations Impaired cognition Inherited Institutes Kidney Diseases Knowledge Latino Latino Population Life Style Lipids Liver diseases Los Angeles Macular degeneration Mexican Mexican Americans National Eye Institute National Heart, Lung, and Blood Institute Native Americans Open-Angle Glaucoma Ophthalmic examination and evaluation Outcome Participant Pathway interactions Periodontal Diseases Phenotype Physical activity Population Positioning Attribute Prevalence Probability Protocols documentation Puerto Rican Questionnaires Reporting Research Research Design Research Support Resources Risk Factors Sampling Serum Sleep Disorders South American Standardization Stroke Study of Latinos Systemic disease Time United States National Institutes of Health Vision Visit Visual impairment Weight aged blind blood pressure elevation burden of illness cohort design diabetic epidemiology study genetic analysis hearing impairment inflammatory marker innovation lymphotoxin beta novel population based prevent prospective racial and ethnic recruit social culture sociodemographics

项目摘要

PROJECT SUMMARY/ABSTRACT This application proposes an ancillary eye study to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). HCHS/SOL is a prospective, population-based, multicenter cohort, funded by the National Heart, Lung, and Blood Institute (NHLBI) and 6 other National Institutes of Health (NIH) Institutes, that is designed to 1) assess disease burden; and, 2) address cardiovascular disease (CVD), stroke, asthma, chronic obstructive pulmonary disease, sleep disorders, dental caries and periodontal disease, hearing impairment, diabetes, kidney and liver disease, and cognitive impairment. This landmark study, the largest ever conducted in Hispanics/Latinos, constitutes a national resource of extensive, high-quality phenotypic and genotypic data. Participants include those of Mexican, Cuban, Dominican, Puerto Rican, Central and South American, and Other origins. HSHC/SOL recruited 16,415 participants for Visit #1 (2008-2011); data collection for Visit #2 (2014-2017) concluded 12/17 (Chicago and Miami Field Centers: 82.3% participation rate); and, NHLBI contracted HCHS/SOL Visit #3 (2019-2022) funding to serve as a platform for ancillary studies. We will recruit and perfom a detailed eye exam on 2500 HCHS/SOL participants from Chicago and Miami aged ≥40 years to coincide with Visit #3. The HCHS/SOL Coordinating Center will provide direction in oversampling older adults to maximize disease detection efficiency, with sampling weights reflecting probabilities of selection to maintain accurate prevalence rates. Latinos of diverse backgrounds as in HCHS/SOL represent a rich sociocultural and genetically admixed group, inheriting a mixture of European, Native American, and African ancestry from populations previously isolated. As such, the HCHS/SOL Eye Study will represent the first highly admixed eye epidemiology cohort. This heterogeneity and intrinsic variability, essential in basic and clinical research, innovatively positions the HCHS/SOL Eye Study to assess important etiologic pathways amid prevalent risk factors and outcomes that cannot be assessed with homogenous cohorts. We propose to collect high-quality eye outcome data, identical to National Eye Institute (NEI)-funded population-based cohorts, which will allow the eye epidemiology community to, for the first time, assess novel hypotheses associated with systemic disease in a well-characterized, diverse cohort. The HCHS/SOL Eye Study is designed to 1) assess and compare the 2010 age-standardized prevalence of chronic eye disease across Hispanic/Latino groups using previously constructed HCHS/SOL “genetic analysis groups” (Mainland: Mexicans, Central and South Americans; and, Caribbean: Cubans, Dominicans, and Puerto Ricans); and, 2) assess whether prevalent disease is associated with novel CVD, biomedical, and sociocultural risk factors. Proposed research leverages NHLBI-funded epidemiologic research supported by 6 other NIH Institutes, and represents a significant opportunity for highly innovative and efficient epidemiologic eye research.

项目概要/摘要本申请提议对西班牙裔社区健康研究/拉丁裔研究进行辅助眼科研究 (HCHS/SOL) HCHS/SOL 是一个基于人群的前瞻性多中心队列，由国家心脏中心资助。肺和血液研究所 (NHLBI) 以及其他 6 个国立卫生研究院 (NIH) 研究所，旨在 1) 评估疾病负担；2) 解决心血管疾病 (CVD)、中风、哮喘、慢性阻塞性肺疾病肺部疾病、睡眠障碍、龋齿和牙周病、听力障碍、糖尿病、这项具有里程碑意义的研究是有史以来规模最大的研究。西班牙裔/拉丁裔构成了广泛、高质量的表型和基因型数据的国家资源。参与者包括墨西哥、古巴、多米尼加、波多黎各、中美洲和南美洲以及其他来源。HSHC/SOL 为访问#1（2008-2011）招募了 16,415 名参与者；为访问#2 收集数据。 (2014-2017) 12/17 结束（芝加哥和迈阿密场地中心：82.3% 参与率）；以及 NHLBI 与 HCHS/SOL Visit #3（2019-2022）资助签订合同，作为辅助研究的平台。对来自芝加哥和迈阿密的 2500 名年龄≥40 岁的 HCHS/SOL 参与者进行详细的眼部检查与访问#3 一致，HCHS/SOL 协调中心将提供对老年人进行过度抽样的指导。最大限度地提高疾病检测效率，采样权重反映选择概率以维持 HCHS/SOL 等不同背景的拉丁裔代表了丰富的社会文化和文化背景。基因混合群体，继承了欧洲、美洲原住民和非洲血统的混合体因此，HCHS/SOL 眼睛研究将代表第一个高度混合的眼睛。这种流行病学队列的异质性和内在变异性对于基础和临床研究至关重要，创新性地定位 HCHS/SOL 眼科研究，以评估普遍风险中的重要病因途径我们建议收集高质量的因素和结果。眼部结果数据与国家眼科研究所 (NEI) 资助的基于人群的队列相同，这将允许眼流行病学界首次评估与系统性眼病相关的新假设 HCHS/SOL 眼科研究旨在 1) 评估和评估。比较 2010 年西班牙裔/拉丁裔群体慢性眼病的年龄标准化患病率使用先前构建的 HCHS/SOL“遗传分析组”（大陆：墨西哥人、中部和南美洲人；以及加勒比海地区：古巴人、多米尼加人和波多黎各人）；以及，2) 评估是否流行疾病与新的 CVD、生物医学和社会文化危险因素相关。研究利用 NHLBI 资助的流行病学研究，并得到其他 6 个 NIH 研究所的支持，并代表这是高度创新和高效的流行病学眼科研究的重要机会。