Fluoride, Dietary, and Other Factors Related to Young Adult Bone Measures and Dental Caries

氟化物、饮食和其他与年轻人骨测量和龋齿相关的因素

基本信息

批准号：
9319667
负责人：
STEVEN M. LEVY
金额：
$ 132.87万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-04-01 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9319667
关键词：
19 year old 3-Dimensional 5 year old Accelerometer Address Adipose tissue Adolescence Adolescent Adult Adverse effects Affect Age Age-Years Algorithms Architecture Behavior Belief Birth Body Composition Bone Development Bone Diseases Child Childhood Clinical Cohort Studies Data Data Collection Dental caries Development Diet Dietary Alcohol Dietary intake Disease Distal Dual-Energy X-Ray Absorptiometry Elderly Fluorides Foundations Fracture Future Generations Genetic Geometry Growth Guidelines Health Health Personnel Individual Intervention Investigation Iowa Knowledge Life Life Style Maintenance Measurement Measures Modality Modeling Osteoporosis Outcome Parents Pattern Peripheral Physical activity Prevention Property Public Health Publishing Questionnaires Recommendation Research Resolution Risk Series Sleep Structure Technology Time Tobacco Tobacco use Weight Work X-Ray Computed Tomography behavior change bone bone geometry bone health bone mass bone quality bone strength cohort cortical bone data modeling data resource density design detector early adolescence emerging adult follow-up improved innovation insight lean body mass middle childhood milk intake neglect prepuberty prevent programs public health relevance research and development response skeletal substantia spongiosa tibia young adult

项目摘要

DESCRIPTION (provided by applicant): The objective of this proposal is to enhance understanding of normal bone development and its determinants by extending our assessments of the unique IBDS cohort into early adulthood (age 23 years) to address major questions about the important transition period from late adolescence to early adulthood. We will obtain age 23 bone outcomes (DXA, pQCT, and MDCT); collect detailed dietary, alcohol, tobacco, sleep, physical activity and body composition data; and model the variability in individual development of whole bone, and trabecular and cortical bone micro-architecture. Specifically, we propose to: 1) Determine the impact of changes in physical attributes (weight, adipose tissue, lean body mass), and lifestyle behaviors (physical activity, dietary intakes, tobacco use, and sleep) during the adolescent-adult transition (measured at 19, 21 and 23 years of age) on changes in measures of bone mass, density, geometry and micro-architecture derived from DXA, pQCT, and MDCT (measured at 19 and 23 years of age), and 2) Assess the relationships between levels and patterns of physical attributes, physical activity, dietary intakes, and other factors from 5 to 23 years of age and during the pre-pubertal, peri-pubertal, and post-pubertal developmental periods on measures of bone mass, density, geometry and micro-architecture, assessed both at age 23 when bone development is largely complete, as well as longitudinally from age 5 to 23. Late adolescence/early adulthood is a period of major lifestyle behavior changes, but major gaps remain in our understanding of the effects of modifiable and non-modifiable factors on bone development during the adolescent-adult transition period. This period is important in determining future risk for osteoporosis and bone fractures. Few studies have assessed bone outcomes and their determinants longitudinally from middle childhood to early adulthood. The Iowa Bone Development Study (IBDS), in its 17th year, is investigating the effects of physical attributes, lifestyle behaviors, dietary intakes, and other factors on bone development and micro-architecture. We assessed bone measures at ages 5, 8, 11, 13, 15, and 17 years using dual-energy x-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT), collected dietary data from birth, and assessed physical activity by accelerometry and questionnaire from age 5. Analogous cross-sectional measures for cohort parents are also available. Age 19 exams are in progress (n=255 to date), with the addition of high-resolution multi-detector CT scans (MDCT) of the distal tibia and advanced algorithms to assess bone micro-architecture, advanced 3-D accelerometry, and more detailed lifestyle questionnaires. Continued follow-up of the IBDS cohort to early adulthood with emphasis on micro-architecture will provide major insights into the relative importance of the many explanatory factors on bone development and strength and the developmental period(s) of greatest impact, providing a strong foundation for future design of strategies and interventions to optimize skeletal health.

描述（由适用提供）：该提案的目的是通过将我们对独特的IBDS队列的评估扩展到成年早期（23岁）来提高对正常骨骼发育及其决定者的理解，以解决有关从青少年晚期到成年早期的重要过渡期的重大问题。我们将获得23岁的骨结局（DXA，PQCT和MDCT）；收集详细的饮食，酒精，烟草，睡眠，体育锻炼和身体成分数据；并建模整个骨骼的个体发育以及小梁和皮质骨微体系结构的变异性。具体而言，我们提出：1）确定身体属性变化（体重，脂肪组织，瘦体重）和生活方式行为（体育活动，饮食摄入量，烟草使用和睡眠）在青少年异族过渡期间（在19、21和23岁时都在年龄衡量的年龄范围内衡量的骨骼，密度和MICTOTA，几何形式和MIPRO-intecture streative streative）的影响（烟草摄入量，烟草使用和睡眠）的影响。 MDCT（在19岁和23岁时衡量），以及2）评估物理属性的水平和模式之间的关系，体育活动，饮食摄入量以及5至23岁的其他因素，以及在骨，密度，密度，几何学和微观核能的测量中，均在骨骼质量，密度和微观方面均在骨骼，骨骼范围内均在骨骼中均纳入23时，在骨骼质量，密度和微观方面均在23岁时均纳入骨骼，并在青年前，普遍期间和花生后期的关系。从5岁到23岁的纵向。青少年晚期/成年早期是一个重大生活方式行为的时期，但是在我们对青少年成年过渡期间可修改和不可修改因素对骨骼发育影响的影响的理解中仍然存在重大差距。这个时期对于确定骨质疏松和骨碎片的未来风险很重要。从童年中期到成年初期，很少有研究纵向评估骨骼结局及其决定词。爱荷华州骨骼发展研究（IBDS）在其第17年，正在研究物理属性，生活方式行为，饮食摄入量以及其他因素对骨骼发育和微体系结构的影响。我们使用双能量X射线绝对映射（DXA）（DXA）和外周定量计算机断层扫描（PQCT）评估了5、8、11、13、15和17岁的骨骼测量，从出生中收集的饮食数据，并通过5年龄的5年龄来评估饮食数据，并通过加速度计算和调查表进行了调查。年龄19的考试正在进行中（迄今为止n = 255），添加了胫骨远端和先进算法的高分辨率多探测器CT扫描（MDCT），以评估骨微分析，先进的3-D加速度测定法和更详细的生活方式问卷。继续对IBDS队列进行成年早期的后续后续行动，重点是微观结构，将为许多利用因素在骨骼发育和力量方面的相对重要性以及最大影响的发展时期的相对重要性，为未来的战略设计和干预措施的基础提供了强大的基础优化骨骼健康。