Secondary Analyses of Adolescent Caries, Including Fluoride, Diet & Other Factors

青少年龋齿的二次分析，包括氟化物、饮食

• 批准号: 8612838
• 负责人: STEVEN M. LEVY
• 金额: $ 15.1万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-10 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8612838
• 关键词: Address; Adolescence; Adolescent; Age; Applications Grants; Attention; Beverages; Birth; Caries prevention; Child; Childhood; Cohort Studies; Complex; Consumption; Data; Data Analyses; Demographic Factors; Dental Hygiene; Dental caries; Development; Diet; Dietary Factors; Dietary Practices; Disease; Etiology; Exposure to; Fluorides; Goals; Health behavior; Incidence; Individual; Intake; Iowa; Literature; Oral health; Outcome; Pattern; Period Analysis; Prevalence; Prevention program; Public Health; Public Policy; Recruitment Activity; Relative (related person); Research; Risk; Risk Factors; Role; Sales; Secondary Schools; Time; Work; age group; cohort; demographics; early childhood; experience; improved; permanent tooth; prevent; programs; public health relevance; sugar; theories

A century after theories identified the prominent roles of sugars in dental caries etiology and the discovery of the beneficial effects of fluorides, caries remains a highly prevalent disease throughout childhood, including adolescence. Adolescents' greater independence and frequent exposure to sugared beverages (e.g., soda pop) appear to place them at greater risk than at younger ages. However, these caries incidence patterns and relationships with risk factors are poorly understood because there are few studies of caries incidence or risk factors among adolescent subjects. Since 1991, using a cohort recruited at birth, the ongoing Iowa Fluoride Study (IFS) has comprehensively assessed the relationships between dietary data and fluoride exposures and dental caries in individuals at ages 5, 9, and 13. As caries continues to be a significant disease in adolescents, the proposed study provides a unique opportunity to assess the effects of socio-demographic, dietary, fluoride, and other factors on the incidence of dental caries during adolescence from age 13 to 17 years in our cohort. The main objectives of this proposal are to 1) conduct detailed secondary analyses of patterns of dental caries of the permanent dentition at age 17 and caries incidence from 13 to 17, and 2) comprehensively examine the relationships among dental caries incidence from age 13 to 17 (and age 17 prevalence) and dietary, fluoride, prior caries experience, and socio-demographic factors. Multivariable analyses will assess the relationships between and interactions among caries outcomes (incidence/increments and prevalence/counts) and longitudinally-collected data on various dietary patterns, oral health behaviors, fluoride exposures, previous caries experience, socio-demographics, and other factors. We will then assess the consistency of our findings concerning caries risk factors for ages 13 to 17 with those from analyses of caries risk factors during earlier periods from ages 5 to 9 and 9 to 13. As studies involving recruitment and successful retention of a cohort from birth are extremely rare, the Iowa Fluoride Study offers a unique opportunity to study these relationships in unprecedented detail, enhancing our ability to develop effective adolescent caries prevention programs.

一个世纪后，理论确定了糖在龋齿病因学中的重要作用，并发现了这一点 尽管氟化物的有益作用，龋齿仍然是整个儿童期高度流行的疾病，包括 青春期。青少年更加独立并经常接触含糖饮料（例如苏打水） pop）似乎使他们比年轻时面临更大的风险。然而，这些龋齿的发病模式和 由于对龋齿发生率或风险的研究很少，人们对与风险因素的关系知之甚少 青少年受试者的因素。自 1991 年以来，爱荷华州氟化物研究中心使用出生时招募的队列 研究 (IFS) 全面评估了饮食数据与氟化物暴露之间的关系， 5、9 和 13 岁人群的龋齿。由于龋齿仍然是青少年的一种重要疾病， 拟议的研究提供了一个独特的机会来评估社会人口、饮食、氟化物、 以及其他影响我们队列中 13 至 17 岁青春期龋齿发生率的因素。 该提案的主要目标是 1) 对牙科模式进行详细的二次分析 17 岁时恒牙列的龋齿和 13 至 17 岁的龋齿发生率，以及 2) 综合 检查 13 至 17 岁龋齿发病率（以及 17 岁患病率）之间的关系 饮食、氟化物、先前的龋齿经历和社会人口因素。多变量分析将评估 龋齿结果之间的关系和相互作用（发病率/增量和 流行率/计数）以及关于各种饮食模式、口腔健康行为、氟化物的纵向收集数据 暴露情况、以前的龋齿经历、社会人口特征和其他因素。然后我们将评估 我们关于 13 至 17 岁儿童龋齿危险因素的研究结果与龋齿分析结果的一致性 5 至 9 岁和 9 至 13 岁早期的危险因素。作为涉及招募和成功的研究 队列从出生起就被保留的情况极为罕见，爱荷华州氟化物研究提供了一个独特的研究机会 这些关系的细节前所未有，增强了我们开发有效的青少年龋齿的能力 预防计划。