National Biomedical NMR Resource at Madison

麦迪逊国家生物医学 NMR 资源

基本信息

批准号：
9233129
负责人：
Samuel E Butcher
金额：
$ 107.51万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-03-01 至 2020-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9233129
关键词：
Address Advisory Committees Architecture Area Automation Automobile Driving Binding Bioinformatics Biological Biomolecular Nuclear Magnetic Resonance Cells Client Collaborations Communities Complex Computer software Consult Data Data Analyses Data Collection Databases Deposition Development Educational workshop Ensure Environment Environmental Risk Factor Evaluation Feasibility Studies Fostering Genetic Goals Health Human Human Resources Investigation Knowledge Label Magnetic Resonance Manuscripts Measures Membrane Proteins Methods Modeling Modernization NMR Spectroscopy Natural Products Newsletter Nuclear Magnetic Resonance Nuclear Protein Nuclear Proteins Nucleic Acids Pharmaceutical Preparations Physiologic pulse Preparation Procedures Process Production Program Development Protein Biosynthesis Proteins Publications RNA Recovery Research Research Personnel Resources Roentgen Rays Sampling Scientist Services Site Spectrum Analysis Stable Isotope Labeling Structure Students System Technology Training Update Visit Work biological systems cost data structure design experimental study frontier instrumentation interest learning strategy lectures macromolecule meetings metabolomics molecular dynamics organizational structure posters programs protein complex research and development screening small molecule technology development three dimensional structure tool training opportunity user-friendly web site

项目摘要

DESCRIPTION (provided by applicant): The National Magnetic Resonance Facility at Madison (NMRFAM) is a resource center for biomolecular nuclear magnetic resonance (NMR) spectroscopy and small angle X-ray scattering (SAXS). NMRFAM aims to expand the frontiers of biomolecular NMR spectroscopy through resource technology and development programs in the important areas of (1) high-throughput determination of structures and functions of smaller proteins and RNA molecules, (2) technology for investigating the structure and dynamics of challenging systems, such as complexes, membrane proteins, paramagnetic proteins, and larger RNA molecules, and (3) efficient approaches to metabolomics, screening of small molecules binding to biological macromolecules, and natural product analysis. NMRFAM strives to be a model to the larger biological community for demonstrating cutting-edge capabilities of NMR spectroscopy. With the goal of broadening the scope of its scientific activities, NMRFAM hosts distinguished visiting scientists working in areas related to its research technology development projects. Through its collaborative activities, NMRFAM develops and disseminates advanced approaches that cover all steps in biomolecular NMR investigations. The center offers start-to-finish support for biomedical NMR investigations with assistance in one or more of the following steps: (1) strategy evaluation and experiment design, (2) preparation and labeling of proteins and nucleic acids, (3) feasibility studies, (4) data collection, (5) data analysis and structure determination, (6) data deposition, and (7) manuscript preparation. NMRFAM aims to facilitate the efficient pursuit of new knowledge by providing researchers with resources matched to their particular needs. A major goal is to develop methods for making these investigations faster and less costly as well as applicable to larger classes of proteins and nucleic acids of importance in human health. NMRFAM provides young investigators and experien

描述（由应用提供）：麦迪逊（NMRFAM）的国家磁共振设施是生物分子核磁共振（NMR）光谱和小角度X射线散射（SAXS）的资源中心。 NMRFAM aims to expand the frontiers of biomolecular NMR spectroscopy through resource technology and development programs in the important areas of (1) high-throughput determination of structures and functions of smaller Proteins and RNA molecules, (2) technology for investigating the structure and dynamics of challenge systems, such as complexes, membrane proteins, paramagnetic proteins, and larger RNA molecules, and (3) efficient approaches对于代谢组学，筛选与生物大分子结合的小分子和自然产物分析。 NMRFAM致力于成为更大的生物学群落的模型，以证明NMR光谱的最先进能力。为了扩大其科学活动的范围，NMRFAM主持了与研究技术开发项目相关领域工作的杰出访问科学家。通过其协作活动，NMRFAM的发展和传播了涵盖生物分子NMR投资所有步骤的高级方法。该中心在以下一个或多个步骤中提供帮助的生物医学NMR投资的起始支持：（1）策略评估和实验设计，（2）蛋白质和核酸的准备和标记，（3）可行性研究，（4）数据收集，（5）数据分析和结构确定，（6）数据沉积量，（6）数据沉积和（7）Manscript。 NMRFAM旨在通过为研究人员提供符合其特定需求的资源来促进有效地追求新知识。一个主要目标是开发使这些投资更快，成本较低的方法，并且适用于较大类别的蛋白质和人类健康中重要性的核酸。 NMRFAM为年轻的调查人员和经验提供