The PDX Integrator- Re-purposing KOMP2 informatics to widely disseminate data from Patient Derived Xenografts

PDX Integrator - 重新利用 KOMP2 信息学来广泛传播来自患者来源的异种移植物的数据

• 批准号: 9458368
• 负责人: Helen Elizabeth Parkinson
• 金额: $ 2.88万
• 依托单位: EUROPEAN MOLECULAR BIOLOGY LABORATORY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-15 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9458368
• 关键词: American Association of Cancer Research; Archives; Atlases; Automobile Driving; Biological; Biological Assay; Cancer Biology; Cancer Model; Cancer Patient; Common Data Element; Communities; Community Outreach; Complex; Computer software; Data; Data Set; Data Sources; Databases; Development; Disease Progression; Educational workshop; End Point Assay; Engraftment; Environment; Feedback; Funding; Gene Expression; Grant; Graph; Human; Image; Imagery; Immunocompromised Host; Informatics; International; Intuition; Knockout Mice; Knowledge; Learning; Libraries; Link; Location; Maps; Measures; Metadata; Modeling; Molecular Classification of Tumors; Mouse Strains; Mus; Mutant Strains Mice; Mutation; NCI Thesaurus; Oncogenic; Patients; Pharmaceutical Preparations; Pharmacotherapy; Physiological; Procedures; Publications; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Secure; Site; Standardization; Testing; Therapeutic; To specify; Training; Transplantation; Tumor Biology; Work; Xenograft Model; Xenograft procedure; anticancer research; data acquisition; data modeling; data resource; data visualization; experience; genomic data; implantation; informatics infrastructure; meetings; mouse model; neoplasm resource; oncology; phenome; prevent; prototype; public health relevance; repository; response; social media; software development; success; tool; treatment response; tumor; tumor growth; tumor progression; user-friendly

 DESCRIPTION (provided by applicant): Patient Derived Xenografts are a critical and growing resource for cancer biology. They inform the understanding of cancer progression, treatment and represent a valuable and under integrated resource. These data consist of complex Meta data related to the tumor and its progression in mouse model. Omics, drug, assay and image data provide rich characterization of PDXs and offer integration potential with existing tools, dat archives and analysis platforms. The PDX Integrator will build on existing infrastructure developed for the Knockout Mouse Project 2 and has four tasks: 1) Identify key determinants in PDX models, map to existing data standards and work with the community to define, extend and where necessary modify existing standards 2) Extend the existing KOMP2 data acquisition software to acquire, validate and load PDX associated data 3) Deploy the PDX Integrator to provide user friendly overviews of PDX data including biological image data and graphical visualization of end-point data by adapting the KOMP2 resource data visualization and presentation tools. 4) Targeted community outreach during all stages of the project to determine and prioritize requirements, guide development and promote the PDX Integrator.

 描述（由申请人提供）：患者来源的异种移植物是癌症生物学的重要且不断增长的资源，它们有助于了解癌症进展和治疗，并且代表了与肿瘤相关的复杂元数据。其在小鼠模型、药物、分析和图像数据方面的进展提供了丰富的 PDX 表征，并提供了与现有工具、数据档案和分析平台的集成潜力。 Mouse Project 2 有四项任务：1) 确定 PDX 模型中的关键决定因素，映射到现有数据标准，并与社区合作定义、扩展并在必要时修改现有标准 2) 扩展现有 KOMP2 数据采集软件以获取、验证并加载 PDX 相关数据 3) 部署 PDX Integrator，通过采用 KOMP2 资源数据可视化和演示工具，提供用户友好的 PDX 数据概述，包括生物图像数据和终点数据的图形可视化。 4) 在项目的各个阶段进行有针对性的社区外展，以确定需求并确定其优先级，指导开发并推广 PDX Integrator。