Establishing the GWAS Catalog as a resource for large-scale association studies

建立 GWAS 目录作为大规模关联研究的资源

• 批准号: 10218234
• 负责人: Helen Elizabeth Parkinson
• 金额: $ 81.86万
• 依托单位: EUROPEAN MOLECULAR BIOLOGY LABORATORY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10218234
• 关键词: Catalogs; Collaborations; Communities; Community Developments; Complex; Data; Deposition; Development; Disease; Documentation; Educational workshop; Emerging Technologies; Ensure; Equilibrium; Five-Year Plans; Gender; Genetic; Health; Human; Individual; Industry; Informatics; International; Knowledge; Leadership; Link; Maintenance; Modeling; National Human Genome Research Institute; Parkinson Disease; Pharmacologic Substance; Phase; Play; Process; Production; Publications; Resource Informatics; Resources; Role; Route; Trainers Training; Training; base; community engagement; data integration; drug development; genome wide association study; genomic data; graphical user interface; meetings; online delivery; outreach; programs; research and development; social media; symposium; tool; Catalogs; Collaborations; Communities; Community Developments; Complex; Data; Deposition; Development; Disease; Documentation; Educational workshop; Emerging Technologies; Ensure; Equilibrium; Five-Year Plans; Gender; Genetic; Health; Human; Individual; Industry; Informatics; International; Knowledge; Leadership; Link; Maintenance; Modeling; National Human Genome Research Institute; Parkinson Disease; Pharmacologic Substance; Phase; Play; Process; Production; Publications; Resource Informatics; Resources; Role; Route; Trainers Training; Training; base; community engagement; data integration; drug development; genome wide association study; genomic data; graphical user interface; meetings; online delivery; outreach; programs; research and development; social media; symposium; tool

The GWAS Catalog has been successfully delivered as an ongoing collaboration between EMBL-EBI and NHGRI, which will continue as part of the next five-year plan. Fiona Cunningham joins existing PIs Helen Parkinson and Paul Flicek and together they will deliver the next phase of the Catalog’s development. The Catalog’s dissemination will take place via the graphical user interface, the download function, the API function, access to the Catalog’s codebase, tracker, publications and the outreach activities performed by the Catalog team. The outreach activities will continue to serve the existing user community and aim to grow the user base by targeting specific user groups via use of social media, interactions with data generators, at scientific meetings with the genetics and via the informatics user communities and publishers. New engagement with tools developers and publishers to promote author deposition using community approved standard formats will support the Resource Production and Resource Informatics activities which will implement these tools. Training for the Catalog’s users will be provided via an online training course hosted on the EMBL-EBI’s train online platform. Community workshops will also be offered on request and workshop applications will be submitted to major conferences in conjunction with Ensembl to maximise the ability to access users. The ‘train the trainer’ model will be used to identify individuals who will act as trainers for the Catalog and we will make all training materials and Catalog processes freely available to them. EMBL-EBI’s Industry Program and Open Targets Collaboration will be leveraged to access international pharmaceutical users to ensure that the training has the greatest possible reach. The Catalog‘s Scientific Advisory Board (SAB) will represent the user community and provide a forum for the PIs and EMBL-EBI/NHGRI collaborators to discuss progress in a productive and invested manner. The SAB will meet yearly, prior to the ASHG meeting, and will provide advice on emerging technologies and challenges in the GWAS domain, to support the Catalog in including the latest findings on complex diseases and fundamental knowledge used by research and drug development communities for the benefit of human health. The SAB will also play a role in the Catalog’s community engagement strategy.

GWAS目录已成功地作为Embl-Ebi和 NHGRI将继续作为下一个五年计划的一部分。 Fiona Cunningham加入了现有的PIS Helen 帕金森和保罗·弗里斯克（Paul Flicek）以及他们将共同提供目录开发的下一阶段。这 目录的传播将通过图形用户界面，下载功能，API进行 功能，访问目录的代码库，跟踪器，出版物以及由 目录团队。外展活动将继续为现有用户社区服务，并旨在发展 通过使用社交媒体，与数据生成器的交互，AT来针对特定用户组的用户群 与遗传学以及信息用户社区和出版商的科学会议。新的 与工具开发人员和出版商的互动以使用社区批准的 标准格式将支持资源生产和资源信息学活动 实施这些工具。将通过托管的在线培训课程为目录的用户提供培训 EMBL-EBI的火车在线平台。还将根据要求和研讨会提供社区研讨会 申请将与Ensembl一起提交主要会议，以最大程度地提交 访问用户。 “培训培训师”模型将用于识别将充当培训师的个人 目录，我们将免费提供所有培训材料和目录流程。 embl-ebi 行业计划和开放目标协作将被利用以访问国际药品 用户确保培训具有最大的影响力。目录的科学顾问委员会 （SAB）将代表用户社区，并为PIS和EMBL-EBI/NHGRI合作者提供论坛 以富有成效和投资的方式讨论进度。 SAB将在ASHG之前每年开会 开会，并将提供有关GWAS领域新兴技术和挑战的建议，以支持 该目录包括有关复杂疾病和研究基本知识的最新发现 和药物开发社区的利益。 SAB还将在 目录的社区参与策略。